ID   URED_YERPS              Reviewed;         321 AA.
AC   P52316; Q667Q4;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   11-JUL-2001, sequence version 2.
DT   25-MAY-2022, entry version 92.
DE   RecName: Full=Urease accessory protein UreD {ECO:0000255|HAMAP-Rule:MF_01384};
GN   Name=ureD {ECO:0000255|HAMAP-Rule:MF_01384}; OrderedLocusNames=YPTB2938;
OS   Yersinia pseudotuberculosis serotype I (strain IP32953).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Yersinia.
OX   NCBI_TaxID=273123;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=IP 2777;
RX   PubMed=9125594; DOI=10.1128/iai.65.5.1985-1990.1997;
RA   Riot B., Berche P., Simonet M.;
RT   "Urease is not involved in the virulence of Yersinia pseudotuberculosis in
RT   mice.";
RL   Infect. Immun. 65:1985-1990(1997).
RN   [2]
RP   SEQUENCE REVISION TO C-TERMINUS.
RA   Riot B.;
RL   Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IP32953;
RX   PubMed=15358858; DOI=10.1073/pnas.0404012101;
RA   Chain P.S.G., Carniel E., Larimer F.W., Lamerdin J., Stoutland P.O.,
RA   Regala W.M., Georgescu A.M., Vergez L.M., Land M.L., Motin V.L.,
RA   Brubaker R.R., Fowler J., Hinnebusch J., Marceau M., Medigue C.,
RA   Simonet M., Chenal-Francisque V., Souza B., Dacheux D., Elliott J.M.,
RA   Derbise A., Hauser L.J., Garcia E.;
RT   "Insights into the evolution of Yersinia pestis through whole-genome
RT   comparison with Yersinia pseudotuberculosis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:13826-13831(2004).
CC   -!- FUNCTION: Required for maturation of urease via the functional
CC       incorporation of the urease nickel metallocenter. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
CC   -!- SUBUNIT: UreD, UreF and UreG form a complex that acts as a GTP-
CC       hydrolysis-dependent molecular chaperone, activating the urease
CC       apoprotein by helping to assemble the nickel containing metallocenter
CC       of UreC. The UreE protein probably delivers the nickel.
CC       {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SIMILARITY: Belongs to the UreD family. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
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DR   EMBL; U40842; AAA87858.2; -; Genomic_DNA.
DR   EMBL; BX936398; CAH22176.1; -; Genomic_DNA.
DR   RefSeq; WP_011192842.1; NZ_CP009712.1.
DR   AlphaFoldDB; P52316; -.
DR   SMR; P52316; -.
DR   EnsemblBacteria; CAH22176; CAH22176; YPTB2938.
DR   GeneID; 66844638; -.
DR   KEGG; ypo:BZ17_3690; -.
DR   KEGG; yps:YPTB2938; -.
DR   PATRIC; fig|273123.14.peg.3868; -.
DR   OMA; IPFENAH; -.
DR   Proteomes; UP000001011; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016151; F:nickel cation binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006807; P:nitrogen compound metabolic process; IEA:InterPro.
DR   HAMAP; MF_01384; UreD; 1.
DR   InterPro; IPR002669; UreD.
DR   PANTHER; PTHR33643; PTHR33643; 1.
DR   Pfam; PF01774; UreD; 1.
PE   3: Inferred from homology;
KW   Chaperone; Cytoplasm; Nickel insertion.
FT   CHAIN           1..321
FT                   /note="Urease accessory protein UreD"
FT                   /id="PRO_0000067622"
SQ   SEQUENCE   321 AA;  35704 MW;  6581EB103B9B6E1A CRC64;
     MTAQSQNIVE TPSRVRAHAL GVNAPELAKY QDEPAQMRSG AVGKSGYLKL RFAKREHRSI
     LAEMERRVPS LVQKALYWDE EIPELPCVTM ISTSGCILQG DRLATDVHVE AGACAHVTTQ
     SATKVHMMNA NYASQIQNFI VEEGGYLEFM PDPLIPHRNS RFITDTTISI HPTATAIYSE
     VLMSGRKYHH ADERFGFDVY SSRVAAQNLA GKELFVEKYV LEPKVESLDA VGVMQTFDAF
     GNVILLTPKE HHDRILARVP AHFDIKGGIA SGATRLPNDC GLVFKALGID SAGVKAEIRQ
     FWKIAREEIL GVTLPEQFLW R