CAD20_HUMAN
ID CAD20_HUMAN Reviewed; 801 AA.
AC Q9HBT6; Q495S3;
DT 24-OCT-2001, integrated into UniProtKB/Swiss-Prot.
DT 26-FEB-2008, sequence version 2.
DT 03-AUG-2022, entry version 160.
DE RecName: Full=Cadherin-20;
DE Flags: Precursor;
GN Name=CDH20; Synonyms=CDH7L3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=10995570; DOI=10.1006/geno.2000.6305;
RA Kools P., Van Imschoot G., van Roy F.;
RT "Characterization of three novel human cadherin genes (CDH7, CDH19, and
RT CDH20) clustered on chromosome 18q22-q23 and with high homology to chicken
RT cadherin-7.";
RL Genomics 68:283-295(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP VARIANTS [LARGE SCALE ANALYSIS] ILE-228; THR-416 AND HIS-746.
RX PubMed=16959974; DOI=10.1126/science.1133427;
RA Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
RA Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P.,
RA Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V.,
RA Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H.,
RA Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W.,
RA Velculescu V.E.;
RT "The consensus coding sequences of human breast and colorectal cancers.";
RL Science 314:268-274(2006).
CC -!- FUNCTION: Cadherins are calcium-dependent cell adhesion proteins. They
CC preferentially interact with themselves in a homophilic manner in
CC connecting cells; cadherins may thus contribute to the sorting of
CC heterogeneous cell types.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane
CC protein.
CC -!- TISSUE SPECIFICITY: Expressed in placenta, adult brain, and fetal
CC brain.
CC -!- DOMAIN: Three calcium ions are usually bound at the interface of each
CC cadherin domain and rigidify the connections, imparting a strong
CC curvature to the full-length ectodomain. {ECO:0000250}.
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DR EMBL; AF217289; AAG23739.1; -; mRNA.
DR EMBL; CH471096; EAW63108.1; -; Genomic_DNA.
DR EMBL; BC101047; AAI01048.1; -; mRNA.
DR EMBL; BC101048; AAI01049.1; -; mRNA.
DR EMBL; BC101049; AAI01050.1; -; mRNA.
DR CCDS; CCDS11977.1; -.
DR RefSeq; NP_114097.2; NM_031891.3.
DR AlphaFoldDB; Q9HBT6; -.
DR SMR; Q9HBT6; -.
DR BioGRID; 118200; 2.
DR IntAct; Q9HBT6; 1.
DR STRING; 9606.ENSP00000262717; -.
DR GlyGen; Q9HBT6; 4 sites.
DR iPTMnet; Q9HBT6; -.
DR PhosphoSitePlus; Q9HBT6; -.
DR BioMuta; CDH20; -.
DR DMDM; 190359622; -.
DR EPD; Q9HBT6; -.
DR MassIVE; Q9HBT6; -.
DR PaxDb; Q9HBT6; -.
DR PeptideAtlas; Q9HBT6; -.
DR PRIDE; Q9HBT6; -.
DR ProteomicsDB; 81590; -.
DR Antibodypedia; 2286; 118 antibodies from 25 providers.
DR DNASU; 28316; -.
DR Ensembl; ENST00000262717.9; ENSP00000262717.3; ENSG00000101542.10.
DR Ensembl; ENST00000536675.2; ENSP00000444767.1; ENSG00000101542.10.
DR Ensembl; ENST00000538374.5; ENSP00000442226.1; ENSG00000101542.10.
DR GeneID; 28316; -.
DR KEGG; hsa:28316; -.
DR MANE-Select; ENST00000262717.9; ENSP00000262717.3; NM_031891.4; NP_114097.2.
DR UCSC; uc002lif.3; human.
DR CTD; 28316; -.
DR DisGeNET; 28316; -.
DR GeneCards; CDH20; -.
DR HGNC; HGNC:1760; CDH20.
DR HPA; ENSG00000101542; Group enriched (brain, retina, tongue).
DR MIM; 605807; gene.
DR neXtProt; NX_Q9HBT6; -.
DR OpenTargets; ENSG00000101542; -.
DR PharmGKB; PA26294; -.
DR VEuPathDB; HostDB:ENSG00000101542; -.
DR eggNOG; KOG3594; Eukaryota.
DR GeneTree; ENSGT00940000158167; -.
DR HOGENOM; CLU_005284_3_1_1; -.
DR InParanoid; Q9HBT6; -.
DR OMA; HEQNTFY; -.
DR OrthoDB; 217088at2759; -.
DR PhylomeDB; Q9HBT6; -.
DR TreeFam; TF329887; -.
DR PathwayCommons; Q9HBT6; -.
DR SignaLink; Q9HBT6; -.
DR SIGNOR; Q9HBT6; -.
DR BioGRID-ORCS; 28316; 7 hits in 1062 CRISPR screens.
DR ChiTaRS; CDH20; human.
DR GenomeRNAi; 28316; -.
DR Pharos; Q9HBT6; Tbio.
DR PRO; PR:Q9HBT6; -.
DR Proteomes; UP000005640; Chromosome 18.
DR RNAct; Q9HBT6; protein.
DR Bgee; ENSG00000101542; Expressed in ventricular zone and 87 other tissues.
DR Genevisible; Q9HBT6; HS.
DR GO; GO:0005912; C:adherens junction; IBA:GO_Central.
DR GO; GO:0016342; C:catenin complex; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0045296; F:cadherin binding; IBA:GO_Central.
DR GO; GO:0005509; F:calcium ion binding; IBA:GO_Central.
DR GO; GO:0034332; P:adherens junction organization; IBA:GO_Central.
DR GO; GO:0016339; P:calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules; IBA:GO_Central.
DR GO; GO:0000902; P:cell morphogenesis; IBA:GO_Central.
DR GO; GO:0098742; P:cell-cell adhesion via plasma-membrane adhesion molecules; IBA:GO_Central.
DR GO; GO:0007043; P:cell-cell junction assembly; IBA:GO_Central.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR Gene3D; 4.10.900.10; -; 1.
DR InterPro; IPR039808; Cadherin.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR000233; Cadherin_cytoplasmic-dom.
DR InterPro; IPR027397; Catenin-bd_sf.
DR PANTHER; PTHR24027; PTHR24027; 1.
DR Pfam; PF00028; Cadherin; 5.
DR Pfam; PF01049; Cadherin_C; 1.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 5.
DR SUPFAM; SSF49313; SSF49313; 5.
DR PROSITE; PS00232; CADHERIN_1; 3.
DR PROSITE; PS50268; CADHERIN_2; 5.
PE 2: Evidence at transcript level;
KW Calcium; Cell adhesion; Cell membrane; Cleavage on pair of basic residues;
KW Glycoprotein; Membrane; Metal-binding; Reference proteome; Repeat; Signal;
KW Transmembrane; Transmembrane helix.
FT SIGNAL 1..34
FT /evidence="ECO:0000255"
FT PROPEP 35..59
FT /evidence="ECO:0000255"
FT /id="PRO_0000003819"
FT CHAIN 60..801
FT /note="Cadherin-20"
FT /id="PRO_0000003820"
FT TOPO_DOM 60..619
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 620..640
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 641..801
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 61..165
FT /note="Cadherin 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 166..274
FT /note="Cadherin 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 275..389
FT /note="Cadherin 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 390..494
FT /note="Cadherin 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 494..610
FT /note="Cadherin 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT CARBOHYD 261
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 420
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 461
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 542
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VARIANT 228
FT /note="M -> I (in a breast cancer sample; somatic
FT mutation)"
FT /evidence="ECO:0000269|PubMed:16959974"
FT /id="VAR_036103"
FT VARIANT 328
FT /note="P -> H (in dbSNP:rs1943330)"
FT /id="VAR_039119"
FT VARIANT 371
FT /note="Q -> R (in dbSNP:rs35923922)"
FT /id="VAR_039120"
FT VARIANT 391
FT /note="P -> L (in dbSNP:rs17068463)"
FT /id="VAR_039121"
FT VARIANT 416
FT /note="P -> T (in a breast cancer sample; somatic
FT mutation)"
FT /evidence="ECO:0000269|PubMed:16959974"
FT /id="VAR_036104"
FT VARIANT 746
FT /note="Q -> H (in a breast cancer sample; somatic
FT mutation)"
FT /evidence="ECO:0000269|PubMed:16959974"
FT /id="VAR_036105"
FT CONFLICT 621
FT /note="A -> P (in Ref. 1; AAG23739)"
FT /evidence="ECO:0000305"
FT CONFLICT 694
FT /note="A -> G (in Ref. 1; AAG23739)"
FT /evidence="ECO:0000305"
FT CONFLICT 709
FT /note="S -> F (in Ref. 1; AAG23739)"
FT /evidence="ECO:0000305"
FT CONFLICT 739
FT /note="A -> T (in Ref. 1; AAG23739)"
FT /evidence="ECO:0000305"
FT CONFLICT 755
FT /note="S -> P (in Ref. 1; AAG23739)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 801 AA; 88993 MW; 6B8B226519F49C5E CRC64;
MWTSGRMSNA KNWLGLGMSL YFWGLMDLTT TVLSDTPTPQ GELEALLSDK PQSHQRTKRS
WVWNQFFVLE EYTGTDPLYV GKLHSDMDRG DGSIKYILSG EGAGIVFTID DTTGDIHAIQ
RLDREERAQY TLRAQALDRR TGRPMEPESE FIIKIQDIND NEPKFLDGPY VATVPEMSPV
GTSVIQVTAT DADDPTYGNS ARVVYSILQG QPYFSVDSKT GVIRTALMNM DREAKEYYEV
IIQAKDMGGQ LGGLAGTTTV NITLSDVNDN PPRFPQKHYQ MSVLESAPIS STVGRVFAKD
LDEGINAEMK YTIVDGDGAD AFDISTDPNF QVGIITVKKP LSFESKKSYT LKVEGANPHL
EMRFLNLGPF QDTTTVHISV EDVDEPPVFE PGFYFVEVPE DVAIGTTIQI ISAKDPDVTN
NSIRYSIDRS SDPGRFFYVD ITTGALMTAR PLDREEFSWH NITVLAMEMN NPSQVGSVPV
TIKVLDVNDN APEFPRFYEA FVCENAKAGQ LIQTVSAVDQ DDPRNGQHFY YSLAPEAANN
PNFTIRDNQD NTARILTRRS GFRQQEQSVF HLPILIADSG QPVLSSTGTL TIQVCSCDDD
GHVMSCSPEA YMLPVSLSRG ALIAILACIF VLLVLVLLIL SMRRHRKQPY IIDDEENIHE
NIVRYDDEGG GEEDTEAFDI AAMWNPREAQ AGAAPKTRQD MLPEIESLSR YVPQTCAVNS
TVHSYVLAKL YEADMDLWAP PFDSLQTYMF EGDGSVAGSL SSLQSATSDS EQSFDFLTDW
GPRFRKLAEL YGASEGPAPL W
