CAD20_MOUSE
ID CAD20_MOUSE Reviewed; 801 AA.
AC Q9Z0M3;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 03-AUG-2022, entry version 150.
DE RecName: Full=Cadherin-20;
DE AltName: Full=Cadherin-7;
DE Flags: Precursor;
GN Name=Cdh20; Synonyms=Cdh7;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC STRAIN=SWR/J; TISSUE=Eye;
RX PubMed=10433813; DOI=10.1006/mcne.1999.0764;
RA Faulkner-Jones B.E., Godinho L.N., Reese B.E., Pasquini G.F., Ruefli A.,
RA Tan S.S.;
RT "Cloning and expression of mouse cadherin-7, a type-II cadherin isolated
RT from the developing eye.";
RL Mol. Cell. Neurosci. 14:1-16(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Diencephalon;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RC STRAIN=BALB/cJ;
RX PubMed=15273735; DOI=10.1038/sj.onc.1207675;
RA Moore R., Champeval D., Denat L., Tan S.S., Faure F., Julien-Grille S.,
RA Larue L.;
RT "Involvement of cadherins 7 and 20 in mouse embryogenesis and melanocyte
RT transformation.";
RL Oncogene 23:6726-6735(2004).
CC -!- FUNCTION: Cadherins are calcium-dependent cell adhesion proteins. They
CC preferentially interact with themselves in a homophilic manner in
CC connecting cells; cadherins may thus contribute to the sorting of
CC heterogeneous cell types (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I
CC membrane protein {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed in brain. Highest level of expression in
CC the retina. In embryo it is synthesized by the forebrain, anterior
CC neural ridge, developing visual system, primitive external granular
CC layer of the cerebellum and a subset of neural crest cells likely to
CC develop into melanoblasts. {ECO:0000269|PubMed:10433813,
CC ECO:0000269|PubMed:15273735}.
CC -!- DEVELOPMENTAL STAGE: Expressed during embryogenesis.
CC {ECO:0000269|PubMed:15273735}.
CC -!- DOMAIN: Three calcium ions are usually bound at the interface of each
CC cadherin domain and rigidify the connections, imparting a strong
CC curvature to the full-length ectodomain. {ECO:0000250}.
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DR EMBL; AF007116; AAD01278.1; -; mRNA.
DR EMBL; AK034475; BAC28721.1; -; mRNA.
DR EMBL; BC119606; AAI19607.1; -; mRNA.
DR EMBL; BC119607; AAI19608.1; -; mRNA.
DR CCDS; CCDS15203.1; -.
DR RefSeq; NP_035930.1; NM_011800.4.
DR AlphaFoldDB; Q9Z0M3; -.
DR SMR; Q9Z0M3; -.
DR STRING; 10090.ENSMUSP00000052078; -.
DR GlyGen; Q9Z0M3; 4 sites.
DR iPTMnet; Q9Z0M3; -.
DR PhosphoSitePlus; Q9Z0M3; -.
DR PaxDb; Q9Z0M3; -.
DR PeptideAtlas; Q9Z0M3; -.
DR PRIDE; Q9Z0M3; -.
DR ProteomicsDB; 265495; -.
DR Antibodypedia; 2286; 118 antibodies from 25 providers.
DR DNASU; 23836; -.
DR Ensembl; ENSMUST00000062528; ENSMUSP00000052078; ENSMUSG00000050840.
DR GeneID; 23836; -.
DR KEGG; mmu:23836; -.
DR UCSC; uc007cgc.1; mouse.
DR CTD; 28316; -.
DR MGI; MGI:1346069; Cdh20.
DR VEuPathDB; HostDB:ENSMUSG00000050840; -.
DR eggNOG; KOG3594; Eukaryota.
DR GeneTree; ENSGT00940000158167; -.
DR HOGENOM; CLU_005284_3_1_1; -.
DR InParanoid; Q9Z0M3; -.
DR OMA; HEQNTFY; -.
DR OrthoDB; 217088at2759; -.
DR PhylomeDB; Q9Z0M3; -.
DR TreeFam; TF329887; -.
DR BioGRID-ORCS; 23836; 0 hits in 73 CRISPR screens.
DR ChiTaRS; Cdh20; mouse.
DR PRO; PR:Q9Z0M3; -.
DR Proteomes; UP000000589; Chromosome 1.
DR RNAct; Q9Z0M3; protein.
DR Bgee; ENSMUSG00000050840; Expressed in ganglionic layer of retina and 84 other tissues.
DR Genevisible; Q9Z0M3; MM.
DR GO; GO:0005912; C:adherens junction; IBA:GO_Central.
DR GO; GO:0016342; C:catenin complex; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0045296; F:cadherin binding; IBA:GO_Central.
DR GO; GO:0005509; F:calcium ion binding; IBA:GO_Central.
DR GO; GO:0034332; P:adherens junction organization; IBA:GO_Central.
DR GO; GO:0016339; P:calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules; IBA:GO_Central.
DR GO; GO:0000902; P:cell morphogenesis; IBA:GO_Central.
DR GO; GO:0098742; P:cell-cell adhesion via plasma-membrane adhesion molecules; IBA:GO_Central.
DR GO; GO:0007043; P:cell-cell junction assembly; IBA:GO_Central.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR Gene3D; 4.10.900.10; -; 1.
DR InterPro; IPR039808; Cadherin.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR000233; Cadherin_cytoplasmic-dom.
DR InterPro; IPR027397; Catenin-bd_sf.
DR PANTHER; PTHR24027; PTHR24027; 1.
DR Pfam; PF00028; Cadherin; 5.
DR Pfam; PF01049; Cadherin_C; 1.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 5.
DR SUPFAM; SSF49313; SSF49313; 5.
DR PROSITE; PS00232; CADHERIN_1; 3.
DR PROSITE; PS50268; CADHERIN_2; 5.
PE 2: Evidence at transcript level;
KW Calcium; Cell adhesion; Cell membrane; Cleavage on pair of basic residues;
KW Glycoprotein; Membrane; Metal-binding; Reference proteome; Repeat; Signal;
KW Transmembrane; Transmembrane helix.
FT SIGNAL 1..34
FT /evidence="ECO:0000255"
FT PROPEP 35..59
FT /evidence="ECO:0000255"
FT /id="PRO_0000320096"
FT CHAIN 60..801
FT /note="Cadherin-20"
FT /id="PRO_0000320097"
FT TOPO_DOM 60..619
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 620..640
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 641..801
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 61..165
FT /note="Cadherin 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 166..274
FT /note="Cadherin 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 275..389
FT /note="Cadherin 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 390..494
FT /note="Cadherin 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 494..610
FT /note="Cadherin 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT CARBOHYD 261
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 420
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 461
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 542
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 801 AA; 88998 MW; AECF5C47A2D6CFBC CRC64;
MWTTGRMSNA KSWLGLGTSL YFWALMDLTA TVLSSTPMPE VELETLFSGR SQSHQRSKRS
WVWNQFFVLE EYTGTDPLYV GKLHSDMDRG DGSIKYILSG EGAGIVFTID DTTGDIHAIQ
RLDREERAQY TLRAQALDRR TGRPMEPESE FIIKIQDIND NEPKFLDGPY IATVPEMSPV
GTSVIQVTAT DADDPTYGNS ARVVYSILQG QPYFSVDSKT GVIRTALMNM DREAKEYYEV
IIQAKDMGGQ LGGLAGTTTV NITLSDVNDN PPRFPQKHYQ MSVLESAPIS STVGRVFAKD
LDEGINAEMK YTIVDGDGAD AFDINTDQNF QVGIITVKKP LSFESKKSYT LKVEGSNPHL
EMRFLNLGPF QDTTTVHISV EDVDEPPVFE PGFYFVEVPE DVTIGTTIQI ISAKDPDVTN
NSIRYSIDRG SDPGRFFYVD ITTGALMTAR PLDREEFSWH NITVLAMEMN NPSQVGSVAV
TIKVLDVNDN APEFPRFYEA FICENAKAGQ LIQTVSAVDQ DDPHNGQHFY YSLAPEAANN
PNFTVRDNQD NTARILTRRS GFRQQEQSVF YLPILIADSG QPVLSSTGTL TIQVCSCNDD
GHVMSCSPEA YLLPVSLSRG ALIAILACIF VLLVLVLLIL SMRRHRKQPY IIDDDENIHE
NIVRYDDEGG GEEDTEAFDI AAMWNPREAQ AGAAPKTRQD MLPEIESLSR YVPQTCAVSS
TVHSYVLAKL YEADMDLWAP PFDSLQTYMF EGDGSVAGSL SSLQSATSDS EQSFDFLTDW
GPRFRKLAEL YGASEGPAPL W
