UREE_ECO57
ID UREE_ECO57 Reviewed; 154 AA.
AC Q8X9U6; Q7AFH4;
DT 21-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 109.
DE RecName: Full=Urease accessory protein UreE {ECO:0000255|HAMAP-Rule:MF_00822};
GN Name=ureE1 {ECO:0000255|HAMAP-Rule:MF_00822};
GN OrderedLocusNames=Z1146, ECs1325;
GN and
GN Name=ureE2 {ECO:0000255|HAMAP-Rule:MF_00822}; OrderedLocusNames=Z1585;
OS Escherichia coli O157:H7.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83334;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX PubMed=11206551; DOI=10.1038/35054089;
RA Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D., Rose D.J.,
RA Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A., Posfai G.,
RA Hackett J., Klink S., Boutin A., Shao Y., Miller L., Grotbeck E.J.,
RA Davis N.W., Lim A., Dimalanta E.T., Potamousis K., Apodaca J.,
RA Anantharaman T.S., Lin J., Yen G., Schwartz D.C., Welch R.A.,
RA Blattner F.R.;
RT "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL Nature 409:529-533(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T.,
RA Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T., Kuhara S.,
RA Shiba T., Hattori M., Shinagawa H.;
RT "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and
RT genomic comparison with a laboratory strain K-12.";
RL DNA Res. 8:11-22(2001).
RN [3]
RP ABSENCE OF UREASE.
RC STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX PubMed=15470125; DOI=10.1099/mic.0.27280-0;
RA Nakano M., Iida T., Honda T.;
RT "Urease activity of enterohaemorrhagic Escherichia coli depends on a
RT specific one-base substitution in ureD.";
RL Microbiology 150:3483-3489(2004).
CC -!- FUNCTION: Involved in urease metallocenter assembly. Binds nickel.
CC Probably functions as a nickel donor during metallocenter assembly.
CC {ECO:0000255|HAMAP-Rule:MF_00822}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00822}.
CC -!- SIMILARITY: Belongs to the UreE family. {ECO:0000255|HAMAP-
CC Rule:MF_00822}.
CC -!- CAUTION: Neither O157 strain expresses urease due to a truncation of
CC ureD, the last gene of the probable operon. Urease activity is restored
CC in O157 / Sakai upon complementation with wild-type ureD.
CC {ECO:0000305}.
CC -!- CAUTION: This region of the chromosome is duplicated in strain O157:H7
CC / EDL933 but not in O157:H7 / Sakai. {ECO:0000305}.
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DR EMBL; AE005174; AAG55700.1; -; Genomic_DNA.
DR EMBL; AE005174; AAG55291.1; -; Genomic_DNA.
DR EMBL; BA000007; BAB34748.1; -; Genomic_DNA.
DR PIR; E90794; E90794.
DR PIR; G85603; G85603.
DR RefSeq; NP_309352.1; NC_002695.1.
DR RefSeq; WP_000966485.1; NZ_SWKA01000005.1.
DR AlphaFoldDB; Q8X9U6; -.
DR SMR; Q8X9U6; -.
DR STRING; 155864.EDL933_1045; -.
DR EnsemblBacteria; AAG55291; AAG55291; Z1146.
DR EnsemblBacteria; AAG55700; AAG55700; Z1585.
DR EnsemblBacteria; BAB34748; BAB34748; ECs_1325.
DR GeneID; 913913; -.
DR KEGG; ece:Z1146; -.
DR KEGG; ece:Z1585; -.
DR KEGG; ecs:ECs_1325; -.
DR PATRIC; fig|386585.9.peg.1430; -.
DR eggNOG; COG2371; Bacteria.
DR HOGENOM; CLU_093757_2_0_6; -.
DR OMA; AYDARCK; -.
DR Proteomes; UP000000558; Chromosome.
DR Proteomes; UP000002519; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016151; F:nickel cation binding; IEA:UniProtKB-UniRule.
DR GO; GO:0051082; F:unfolded protein binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006457; P:protein folding; IEA:InterPro.
DR GO; GO:0065003; P:protein-containing complex assembly; IEA:InterPro.
DR GO; GO:0019627; P:urea metabolic process; IEA:InterPro.
DR CDD; cd00571; UreE; 1.
DR HAMAP; MF_00822; UreE; 1.
DR InterPro; IPR012406; UreE.
DR InterPro; IPR007864; UreE_C_dom.
DR InterPro; IPR004029; UreE_N.
DR InterPro; IPR036118; UreE_N_sf.
DR Pfam; PF05194; UreE_C; 1.
DR Pfam; PF02814; UreE_N; 1.
DR PIRSF; PIRSF036402; Ureas_acces_UreE; 1.
DR SMART; SM00988; UreE_N; 1.
DR SUPFAM; SSF69287; SSF69287; 1.
PE 3: Inferred from homology;
KW Chaperone; Cytoplasm; Nickel; Nickel insertion; Reference proteome.
FT CHAIN 1..154
FT /note="Urease accessory protein UreE"
FT /id="PRO_0000223414"
SQ SEQUENCE 154 AA; 17307 MW; 72F70AE61667582F CRC64;
MLYLTRRVET PAQTTASVTL PVDMRVKSRI KVTLNDGRQA GLLLPRGLLL RDGDILSNEN
GDEFIKVIAA DEAVSVVRCA DPFMLAKACW HLGNRHVPLQ IMPGELRYHH DHVLDDMLRQ
FGLDVDFAHL PFEPEAGAYA SKSHAHNHDQ EHSH
