ID   CAD2_DICDI              Reviewed;         201 AA.
AC   O97113; Q552V5; Q86A10;
DT   03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   25-MAY-2022, entry version 84.
DE   RecName: Full=Putative calcium-dependent cell adhesion molecule 2;
DE            Short=CAD-2;
DE            Short=DdCAD-2;
GN   Name=cad2; ORFNames=DDB_G0275439;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=AX3-1;
RA   Kim B.-J., Han Y.-H., Kang S.-O.;
RT   "Cloning of DdCAD2 from Dictyostelium discoideum.";
RL   Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=12097910; DOI=10.1038/nature00847;
RA   Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA   Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA   Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA   Noegel A.A.;
RT   "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL   Nature 418:79-85(2002).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
RN   [4]
RP   INDUCTION.
RX   PubMed=17481898; DOI=10.1016/j.cub.2007.04.029;
RA   Bakthavatsalam D., Brazill D., Gomer R.H., Eichinger L., Rivero F.,
RA   Noegel A.A.;
RT   "A G protein-coupled receptor with a lipid kinase domain is involved in
RT   cell-density sensing.";
RL   Curr. Biol. 17:892-897(2007).
CC   -!- FUNCTION: Mediates calcium-dependent cell-cell adhesion during the
CC       early stage of development. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}.
CC   -!- INDUCTION: Expression is controlled by rpkA.
CC       {ECO:0000269|PubMed:17481898}.
CC   -!- SIMILARITY: Belongs to the Dictyostelium CAD family. {ECO:0000305}.
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DR   EMBL; AF076973; AAD17693.1; -; mRNA.
DR   EMBL; AAFI02000013; EAL69470.1; -; Genomic_DNA.
DR   RefSeq; XP_643576.1; XM_638484.1.
DR   AlphaFoldDB; O97113; -.
DR   SMR; O97113; -.
DR   STRING; 44689.DDB0191303; -.
DR   PaxDb; O97113; -.
DR   EnsemblProtists; EAL69470; EAL69470; DDB_G0275439.
DR   GeneID; 8620163; -.
DR   KEGG; ddi:DDB_G0275439; -.
DR   dictyBase; DDB_G0275439; cad2.
DR   HOGENOM; CLU_1362582_0_0_1; -.
DR   InParanoid; O97113; -.
DR   OMA; TEDITFE; -.
DR   PhylomeDB; O97113; -.
DR   PRO; PR:O97113; -.
DR   Proteomes; UP000002195; Chromosome 2.
DR   GO; GO:0005911; C:cell-cell junction; IBA:GO_Central.
DR   GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR   GO; GO:0031012; C:extracellular matrix; HDA:dictyBase.
DR   GO; GO:0005509; F:calcium ion binding; IBA:GO_Central.
DR   GO; GO:0005516; F:calmodulin binding; IBA:GO_Central.
DR   GO; GO:0016339; P:calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules; IBA:GO_Central.
DR   Gene3D; 2.60.40.1720; -; 1.
DR   InterPro; IPR038423; CAD_C_sf.
DR   InterPro; IPR029283; Membrane-bd.
DR   Pfam; PF14564; Membrane_bind; 1.
PE   2: Evidence at transcript level;
KW   Calcium; Cell adhesion; Cell membrane; Membrane; Reference proteome.
FT   CHAIN           1..201
FT                   /note="Putative calcium-dependent cell adhesion molecule 2"
FT                   /id="PRO_0000365722"
SQ   SEQUENCE   201 AA;  22516 MW;  DD0F3505295FADF2 CRC64;
     MSTLGDKESI IFKEKSFGGE KWSLQNGSRY GNQAGALRSL KVGKFCKVNI WDKNGTMQTF
     LGGEYPDITD KLPNVDIVQA IDVQFKYSVD IRFKHNVQGR DPNDFKLTVI PYQLNGVEIV
     SGGDYSGVQI PELNPPDSEI VCQISIREIK WPGQVFANGS IYFKYTPSNN TVSYRKTEGW
     PTNCEIVQDD VSGFTITLKS I