ID   CAD3_DICDI              Reviewed;         213 AA.
AC   Q54MP0;
DT   03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 82.
DE   RecName: Full=Putative calcium-dependent cell adhesion molecule 3;
GN   Name=cad3; ORFNames=DDB_G0285817;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Mediates calcium-dependent cell-cell adhesion during the
CC       early stage of development. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Dictyostelium CAD family. {ECO:0000305}.
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DR   EMBL; AAFI02000080; EAL64530.1; -; Genomic_DNA.
DR   RefSeq; XP_638037.1; XM_632945.1.
DR   AlphaFoldDB; Q54MP0; -.
DR   SMR; Q54MP0; -.
DR   STRING; 44689.DDB0304515; -.
DR   PaxDb; Q54MP0; -.
DR   EnsemblProtists; EAL64530; EAL64530; DDB_G0285817.
DR   GeneID; 8625301; -.
DR   KEGG; ddi:DDB_G0285817; -.
DR   dictyBase; DDB_G0285817; cad3.
DR   eggNOG; ENOG502SGUC; Eukaryota.
DR   HOGENOM; CLU_1362582_0_0_1; -.
DR   InParanoid; Q54MP0; -.
DR   PhylomeDB; Q54MP0; -.
DR   PRO; PR:Q54MP0; -.
DR   Proteomes; UP000002195; Chromosome 4.
DR   GO; GO:0005911; C:cell-cell junction; IBA:GO_Central.
DR   GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR   GO; GO:0005509; F:calcium ion binding; ISS:dictyBase.
DR   GO; GO:0005516; F:calmodulin binding; IBA:GO_Central.
DR   GO; GO:0016339; P:calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules; ISS:dictyBase.
DR   Gene3D; 2.60.40.1720; -; 1.
DR   InterPro; IPR015059; Ca_cell_adhesion_N_dom.
DR   InterPro; IPR038423; CAD_C_sf.
DR   InterPro; IPR011024; G_crystallin-like.
DR   InterPro; IPR029283; Membrane-bd.
DR   Pfam; PF08964; Crystall_3; 1.
DR   Pfam; PF14564; Membrane_bind; 1.
DR   SUPFAM; SSF49695; SSF49695; 1.
PE   3: Inferred from homology;
KW   Calcium; Cell adhesion; Cell membrane; Membrane; Reference proteome.
FT   CHAIN           1..213
FT                   /note="Putative calcium-dependent cell adhesion molecule 3"
FT                   /id="PRO_0000365723"
SQ   SEQUENCE   213 AA;  23602 MW;  E76CC447AE3348B6 CRC64;
     MSVAPTKVKF FFGKNCTGES FEYDEGETVR FNYGDEWNDK FMSCIVGASV KCNIWEHNEI
     DTPTPGKYEQ LAQGSTNNDL TSINGLSKFQ VIPGDFQWAV DVKIVDNIAN TPVGSYEMTL
     IPFGVPQVVC RDGDDFVQMP IPQLSPADSE IVTQVAVRDT RTGVYVANGS CYFKYDPSTG
     QVSIRKPVET FPPNMDTVQD DNTSFIFNLN ATA