UREE_YERPE
ID UREE_YERPE Reviewed; 231 AA.
AC Q9ZFR8; Q0WDM1;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 25-MAY-2022, entry version 128.
DE RecName: Full=Urease accessory protein UreE {ECO:0000255|HAMAP-Rule:MF_00822};
GN Name=ureE {ECO:0000255|HAMAP-Rule:MF_00822};
GN OrderedLocusNames=YPO2668, y1240, YP_2469;
OS Yersinia pestis.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Yersiniaceae; Yersinia.
OX NCBI_TaxID=632;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND LACK OF ROLE IN VIRULENCE.
RC STRAIN=6/69M;
RX PubMed=11119503; DOI=10.1128/iai.69.1.170-176.2001;
RA Sebbane F., Devalckenaere A., Foulon J., Carniel E., Simonet M.;
RT "Silencing and reactivation of urease in Yersinia pestis is determined by
RT one G residue at a specific position in the ureD gene.";
RL Infect. Immun. 69:170-176(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CO-92 / Biovar Orientalis;
RX PubMed=11586360; DOI=10.1038/35097083;
RA Parkhill J., Wren B.W., Thomson N.R., Titball R.W., Holden M.T.G.,
RA Prentice M.B., Sebaihia M., James K.D., Churcher C.M., Mungall K.L.,
RA Baker S., Basham D., Bentley S.D., Brooks K., Cerdeno-Tarraga A.-M.,
RA Chillingworth T., Cronin A., Davies R.M., Davis P., Dougan G., Feltwell T.,
RA Hamlin N., Holroyd S., Jagels K., Karlyshev A.V., Leather S., Moule S.,
RA Oyston P.C.F., Quail M.A., Rutherford K.M., Simmonds M., Skelton J.,
RA Stevens K., Whitehead S., Barrell B.G.;
RT "Genome sequence of Yersinia pestis, the causative agent of plague.";
RL Nature 413:523-527(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KIM10+ / Biovar Mediaevalis;
RX PubMed=12142430; DOI=10.1128/jb.184.16.4601-4611.2002;
RA Deng W., Burland V., Plunkett G. III, Boutin A., Mayhew G.F., Liss P.,
RA Perna N.T., Rose D.J., Mau B., Zhou S., Schwartz D.C., Fetherston J.D.,
RA Lindler L.E., Brubaker R.R., Plano G.V., Straley S.C., McDonough K.A.,
RA Nilles M.L., Matson J.S., Blattner F.R., Perry R.D.;
RT "Genome sequence of Yersinia pestis KIM.";
RL J. Bacteriol. 184:4601-4611(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=91001 / Biovar Mediaevalis;
RX PubMed=15368893; DOI=10.1093/dnares/11.3.179;
RA Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D.,
RA Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L.,
RA Dai R., Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H.,
RA Wang J., Huang P., Yang R.;
RT "Complete genome sequence of Yersinia pestis strain 91001, an isolate
RT avirulent to humans.";
RL DNA Res. 11:179-197(2004).
CC -!- FUNCTION: Involved in urease metallocenter assembly. Binds nickel.
CC Probably functions as a nickel donor during metallocenter assembly.
CC {ECO:0000255|HAMAP-Rule:MF_00822}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00822}.
CC -!- SIMILARITY: Belongs to the UreE family. {ECO:0000255|HAMAP-
CC Rule:MF_00822}.
CC -!- CAUTION: The last gene of this probable operon, ureD, gives rise to a
CC truncated protein. Absence of ureD prevents expression of active
CC urease. Correction of the mutation does not effect virulence in mice in
CC any detectable fashion, suggesting urease is not important in the
CC virulence of Y.pestis (PubMed:11119503). {ECO:0000305|PubMed:11119503}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAM84815.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAS62669.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AF095636; AAC78635.1; -; Genomic_DNA.
DR EMBL; AL590842; CAL21287.1; -; Genomic_DNA.
DR EMBL; AE009952; AAM84815.1; ALT_INIT; Genomic_DNA.
DR EMBL; AE017042; AAS62669.1; ALT_INIT; Genomic_DNA.
DR PIR; AD0325; AD0325.
DR RefSeq; WP_002212230.1; NZ_WUCM01000006.1.
DR RefSeq; YP_002347617.1; NC_003143.1.
DR AlphaFoldDB; Q9ZFR8; -.
DR SMR; Q9ZFR8; -.
DR STRING; 214092.YPO2668; -.
DR PaxDb; Q9ZFR8; -.
DR DNASU; 1146187; -.
DR EnsemblBacteria; AAM84815; AAM84815; y1240.
DR EnsemblBacteria; AAS62669; AAS62669; YP_2469.
DR GeneID; 57976026; -.
DR KEGG; ype:YPO2668; -.
DR KEGG; ypk:y1240; -.
DR KEGG; ypm:YP_2469; -.
DR PATRIC; fig|214092.21.peg.3102; -.
DR eggNOG; COG2371; Bacteria.
DR HOGENOM; CLU_095954_0_0_6; -.
DR OMA; HAIGNQH; -.
DR Proteomes; UP000000815; Chromosome.
DR Proteomes; UP000001019; Chromosome.
DR Proteomes; UP000002490; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016151; F:nickel cation binding; IEA:UniProtKB-UniRule.
DR GO; GO:0051082; F:unfolded protein binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006457; P:protein folding; IEA:InterPro.
DR GO; GO:0065003; P:protein-containing complex assembly; IEA:InterPro.
DR GO; GO:0019627; P:urea metabolic process; IEA:InterPro.
DR CDD; cd00571; UreE; 1.
DR HAMAP; MF_00822; UreE; 1.
DR InterPro; IPR012406; UreE.
DR InterPro; IPR007864; UreE_C_dom.
DR InterPro; IPR004029; UreE_N.
DR InterPro; IPR036118; UreE_N_sf.
DR Pfam; PF05194; UreE_C; 1.
DR Pfam; PF02814; UreE_N; 1.
DR SMART; SM00988; UreE_N; 1.
DR SUPFAM; SSF69287; SSF69287; 1.
PE 3: Inferred from homology;
KW Chaperone; Cytoplasm; Nickel; Nickel insertion; Reference proteome.
FT CHAIN 1..231
FT /note="Urease accessory protein UreE"
FT /id="PRO_0000067641"
FT REGION 185..231
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 196..231
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 231 AA; 25948 MW; D5A68603F7373706 CRC64;
MILIEHILGN VKKDPVWREK LKDATFDLLI LDQREAQKSR CRKSSTQGLD LGISLDRNVV
LADGDVLAWD EETNVAVVVQ INLRDVMVID LSELKSRSPD ELIKTCFELG HALGNQHWKA
VTKHNEVYVP LTVATTMMDS VMRTHGFQHL PFRFVKGAEI LPLLTNSEAR LLFGGAEDTD
THVHVASPLD EPHGSGLHIH GIHSHEEGHS HGDHDHDHSH SHGDHDHDHK H
