ID   UREF2_BRUC2             Reviewed;         243 AA.
AC   A9M616;
DT   22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-FEB-2008, sequence version 1.
DT   25-MAY-2022, entry version 59.
DE   RecName: Full=Urease accessory protein UreF 2 {ECO:0000255|HAMAP-Rule:MF_01385};
GN   Name=ureF2 {ECO:0000255|HAMAP-Rule:MF_01385}; OrderedLocusNames=BCAN_A1387;
OS   Brucella canis (strain ATCC 23365 / NCTC 10854).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Brucellaceae; Brucella/Ochrobactrum group; Brucella.
OX   NCBI_TaxID=483179;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 23365 / NCTC 10854;
RA   Setubal J.C., Bowns C., Boyle S., Crasta O.R., Czar M.J., Dharmanolla C.,
RA   Gillespie J.J., Kenyon R.W., Lu J., Mane S., Mohapatra S., Nagrani S.,
RA   Purkayastha A., Rajasimha H.K., Shallom J.M., Shallom S., Shukla M.,
RA   Snyder E.E., Sobral B.W., Wattam A.R., Will R., Williams K., Yoo H.,
RA   Bruce D., Detter C., Munk C., Brettin T.S.;
RT   "Brucella canis ATCC 23365 whole genome shotgun sequencing project.";
RL   Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for maturation of urease via the functional
CC       incorporation of the urease nickel metallocenter. {ECO:0000255|HAMAP-
CC       Rule:MF_01385}.
CC   -!- SUBUNIT: UreD, UreF and UreG form a complex that acts as a GTP-
CC       hydrolysis-dependent molecular chaperone, activating the urease
CC       apoprotein by helping to assemble the nickel containing metallocenter
CC       of UreC. The UreE protein probably delivers the nickel.
CC       {ECO:0000255|HAMAP-Rule:MF_01385}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01385}.
CC   -!- SIMILARITY: Belongs to the UreF family. {ECO:0000255|HAMAP-
CC       Rule:MF_01385}.
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DR   EMBL; CP000872; ABX62421.1; -; Genomic_DNA.
DR   RefSeq; WP_002966883.1; NC_010103.1.
DR   AlphaFoldDB; A9M616; -.
DR   SMR; A9M616; -.
DR   EnsemblBacteria; ABX62421; ABX62421; BCAN_A1387.
DR   GeneID; 45052380; -.
DR   GeneID; 55591020; -.
DR   KEGG; bcs:BCAN_A1387; -.
DR   HOGENOM; CLU_049215_4_0_5; -.
DR   OMA; HVRLFMN; -.
DR   PhylomeDB; A9M616; -.
DR   Proteomes; UP000001385; Chromosome I.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016151; F:nickel cation binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006807; P:nitrogen compound metabolic process; IEA:InterPro.
DR   Gene3D; 1.10.4190.10; -; 1.
DR   HAMAP; MF_01385; UreF; 1.
DR   InterPro; IPR002639; UreF.
DR   InterPro; IPR038277; UreF_sf.
DR   Pfam; PF01730; UreF; 1.
DR   PIRSF; PIRSF009467; Ureas_acces_UreF; 1.
PE   3: Inferred from homology;
KW   Chaperone; Cytoplasm; Nickel insertion.
FT   CHAIN           1..243
FT                   /note="Urease accessory protein UreF 2"
FT                   /id="PRO_0000344088"
SQ   SEQUENCE   243 AA;  26465 MW;  CE0A0602F0527ECB CRC64;
     MTMRTATITE FSSSYRSLPG LLHLLQFGDS ALPIGGFSFS NGLESAIQQN LVHDKETLRE
     FTLTAMNQAA TSDGIALLTA HRAARADDRG ALQVIDKAVF ERKLNEETRL MTVRMGRKLC
     ELSASIIDDR LNRDWLECIK TAETPGTHPV SLGLAFAALD VDGRDAFGAQ QYGVATTILG
     AALRLMRVSF MDTQKILLEA TSTVAPAYEE IADAGIEDMA SFAPMVDILA AVHVKGHVRM
     FMN