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CAD96_DROME
ID   CAD96_DROME             Reviewed;         773 AA.
AC   Q9VBW3; O18368; Q8SZC9; Q9VBW2;
DT   27-JAN-2003, integrated into UniProtKB/Swiss-Prot.
DT   27-JAN-2003, sequence version 2.
DT   03-AUG-2022, entry version 168.
DE   RecName: Full=Tyrosine kinase receptor Cad96Ca;
DE            EC=2.7.10.1;
DE   AltName: Full=Cadherin-96Ca;
DE   AltName: Full=Tyrosine kinase receptor HD-14;
DE   Flags: Precursor;
GN   Name=Cad96Ca; Synonyms=HD-14; ORFNames=CG10244;
OS   Drosophila melanogaster (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7227;
RN   [1] {ECO:0000305}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley;
RX   PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA   Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA   Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA   George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA   Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA   Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA   Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA   An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA   Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA   Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA   Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA   Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA   Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA   Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA   Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA   Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA   Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA   Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA   Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA   Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA   Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA   Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA   McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA   Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA   Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA   Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA   Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA   Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA   Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA   Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA   Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA   Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA   Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA   Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA   Venter J.C.;
RT   "The genome sequence of Drosophila melanogaster.";
RL   Science 287:2185-2195(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=Berkeley;
RX   PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA   Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA   Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA   Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA   Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA   Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA   Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT   "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT   review.";
RL   Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Berkeley; TISSUE=Embryo;
RX   PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA   Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA   Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA   Celniker S.E.;
RT   "A Drosophila full-length cDNA resource.";
RL   Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN   [4] {ECO:0000305}
RP   NUCLEOTIDE SEQUENCE OF 616-668.
RC   TISSUE=Embryo;
RX   PubMed=9731193; DOI=10.1006/bbrc.1998.9003;
RA   Oates A.C., Wollberg P., Achen M.G., Wilks A.F.;
RT   "Sampling the genomic pool of protein tyrosine kinase genes using the
RT   polymerase chain reaction with genomic DNA.";
RL   Biochem. Biophys. Res. Commun. 249:660-667(1998).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
CC         [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC         COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC         ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1;
CC         Evidence={ECO:0000255|PROSITE-ProRule:PRU10028};
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein
CC       kinase family. Fibroblast growth factor receptor subfamily.
CC       {ECO:0000255|PROSITE-ProRule:PRU00159}.
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DR   EMBL; AE014297; AAF56414.2; -; Genomic_DNA.
DR   EMBL; AY070958; AAL48580.1; -; mRNA.
DR   EMBL; BT001586; AAN71341.1; -; mRNA.
DR   EMBL; BT001657; AAN71412.1; -; mRNA.
DR   EMBL; AJ002910; CAA05745.1; -; Genomic_DNA.
DR   RefSeq; NP_651349.1; NM_143092.3.
DR   AlphaFoldDB; Q9VBW3; -.
DR   SMR; Q9VBW3; -.
DR   BioGRID; 67946; 4.
DR   IntAct; Q9VBW3; 7.
DR   STRING; 7227.FBpp0084248; -.
DR   GlyGen; Q9VBW3; 7 sites.
DR   PaxDb; Q9VBW3; -.
DR   PRIDE; Q9VBW3; -.
DR   DNASU; 43026; -.
DR   EnsemblMetazoa; FBtr0084874; FBpp0084248; FBgn0022800.
DR   GeneID; 43026; -.
DR   KEGG; dme:Dmel_CG10244; -.
DR   CTD; 43026; -.
DR   FlyBase; FBgn0022800; Cad96Ca.
DR   VEuPathDB; VectorBase:FBgn0022800; -.
DR   eggNOG; KOG0200; Eukaryota.
DR   GeneTree; ENSGT00940000166715; -.
DR   HOGENOM; CLU_020235_0_0_1; -.
DR   InParanoid; Q9VBW3; -.
DR   OMA; ANRYVPW; -.
DR   OrthoDB; 637711at2759; -.
DR   PhylomeDB; Q9VBW3; -.
DR   Reactome; R-DME-1257604; PIP3 activates AKT signaling.
DR   Reactome; R-DME-186763; Downstream signal transduction.
DR   Reactome; R-DME-186797; Signaling by PDGF.
DR   Reactome; R-DME-210993; Tie2 Signaling.
DR   Reactome; R-DME-5673001; RAF/MAP kinase cascade.
DR   Reactome; R-DME-6811558; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.
DR   SignaLink; Q9VBW3; -.
DR   BioGRID-ORCS; 43026; 0 hits in 3 CRISPR screens.
DR   GenomeRNAi; 43026; -.
DR   PRO; PR:Q9VBW3; -.
DR   Proteomes; UP000000803; Chromosome 3R.
DR   Bgee; FBgn0022800; Expressed in wing disc and 27 other tissues.
DR   Genevisible; Q9VBW3; DM.
DR   GO; GO:0045177; C:apical part of cell; IDA:FlyBase.
DR   GO; GO:0005887; C:integral component of plasma membrane; ISS:FlyBase.
DR   GO; GO:0043235; C:receptor complex; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0004713; F:protein tyrosine kinase activity; IDA:FlyBase.
DR   GO; GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IBA:GO_Central.
DR   GO; GO:0016339; P:calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules; ISS:FlyBase.
DR   GO; GO:0007030; P:Golgi organization; IMP:FlyBase.
DR   GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR   GO; GO:0045792; P:negative regulation of cell size; IMP:FlyBase.
DR   GO; GO:0033674; P:positive regulation of kinase activity; IBA:GO_Central.
DR   GO; GO:0014068; P:positive regulation of phosphatidylinositol 3-kinase signaling; IMP:FlyBase.
DR   GO; GO:0090303; P:positive regulation of wound healing; IMP:FlyBase.
DR   GO; GO:0006468; P:protein phosphorylation; ISS:FlyBase.
DR   GO; GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IBA:GO_Central.
DR   GO; GO:0042060; P:wound healing; IEP:FlyBase.
DR   InterPro; IPR002126; Cadherin-like_dom.
DR   InterPro; IPR015919; Cadherin-like_sf.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR   InterPro; IPR008266; Tyr_kinase_AS.
DR   InterPro; IPR020635; Tyr_kinase_cat_dom.
DR   Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR   PRINTS; PR00109; TYRKINASE.
DR   SMART; SM00112; CA; 1.
DR   SMART; SM00219; TyrKc; 1.
DR   SUPFAM; SSF49313; SSF49313; 1.
DR   SUPFAM; SSF56112; SSF56112; 1.
DR   PROSITE; PS50268; CADHERIN_2; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Glycoprotein; Kinase; Membrane; Nucleotide-binding; Receptor;
KW   Reference proteome; Signal; Transferase; Transmembrane;
KW   Transmembrane helix; Tyrosine-protein kinase.
FT   SIGNAL          1..48
FT                   /evidence="ECO:0000255"
FT   CHAIN           49..773
FT                   /note="Tyrosine kinase receptor Cad96Ca"
FT                   /id="PRO_0000016797"
FT   TOPO_DOM        49..315
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        316..336
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        337..773
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          58..172
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT   DOMAIN          470..749
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT   REGION          196..302
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          352..373
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          411..447
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        215..237
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        255..302
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        610
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00159,
FT                   ECO:0000255|PROSITE-ProRule:PRU10028"
FT   BINDING         476..484
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT   BINDING         504
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT   CARBOHYD        126
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        164
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        180
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        278
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        279
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        300
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        301
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   773 AA;  86220 MW;  CFD6B8F27EAC46E4 CRC64;
     MVYHHHNHES RIIHCRKQLT SWRRRSLLLT IIVVTATVVS LISQEAEAHN QNAPPILYVR
     ERNWRISETE KVGQIIDRVR AEDPDGDDLI FGIEPRFSLP GGENDASPPE KIPFQIDRET
     GVVTLNESLA GRAGQNFLIY ITVTDGSYTA KNEVFINILG ERENSSGYRP QTSISNVVHN
     ISQFLPRFDQ LPGVQSIRNG LPNSRPGGWY PPVPQNNIFG PPPFGNNYPP PPPNIPGVRG
     EQSGEEEQPD EEVTPTTPVR ISSTTPKSRT KLTPITANNS TRVESAIPAE TTTPSGGHHN
     NSSSPITIFS LKSGTIPIVV TVGGFFVAIA VLLAYLCRRR LCAISRTLKK TKEKEELAKK
     SNQSQLSSTL TDDSRNSMVM QQWQGPVAFA NRYVPWERDQ QMGIATSQLS TGVTNGGVSS
     PGVPSPGTGE PGSNLGPGCL TGGAGSSGAP ENAFAGEANC DRWEFPRYRL KFFNILGEGA
     FGQVWRCEAT NINGNEGITT VAVKTLKESA TEVDRKDLLS ELEVMKSLEP HINVVHLLGC
     CTDKDPTFVI LEYVNRGKLQ TYLRSSRAER HYGNTHGKSN VLTSCDLTSF MYQVAKGMDY
     LTSRGIIHRD LAARNILITD DHTCKVADFG FARDVITSKI YERKSEGKLP IRWMATESLY
     DNIFSVKSDI WSFGILMWEI VTLGSTPYPG ISAADVMRKV RDGYRLEKPE HCRRELYNIM
     YYCWSHDPQE RPLFAEIIQM LDKLLHTEMD YIELERFPDH NYYNIVSLSG EKL
 
 
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