ID   UREF_HAEIN              Reviewed;         235 AA.
AC   P44395;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   22-JUL-2008, sequence version 2.
DT   03-AUG-2022, entry version 97.
DE   RecName: Full=Urease accessory protein UreF {ECO:0000255|HAMAP-Rule:MF_01385};
GN   Name=ureF {ECO:0000255|HAMAP-Rule:MF_01385}; OrderedLocusNames=HI_0537;
OS   Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=71421;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=7542800; DOI=10.1126/science.7542800;
RA   Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA   Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA   McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA   Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA   Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA   Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA   Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA   Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT   "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT   Rd.";
RL   Science 269:496-512(1995).
CC   -!- FUNCTION: Required for maturation of urease via the functional
CC       incorporation of the urease nickel metallocenter. {ECO:0000255|HAMAP-
CC       Rule:MF_01385}.
CC   -!- SUBUNIT: UreD, UreF and UreG form a complex that acts as a GTP-
CC       hydrolysis-dependent molecular chaperone, activating the urease
CC       apoprotein by helping to assemble the nickel containing metallocenter
CC       of UreC. The UreE protein probably delivers the nickel.
CC       {ECO:0000255|HAMAP-Rule:MF_01385}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01385}.
CC   -!- SIMILARITY: Belongs to the UreF family. {ECO:0000255|HAMAP-
CC       Rule:MF_01385}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAC22195.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; L42023; AAC22195.1; ALT_INIT; Genomic_DNA.
DR   PIR; F64075; F64075.
DR   RefSeq; NP_438695.2; NC_000907.1.
DR   RefSeq; WP_005694141.1; NC_000907.1.
DR   AlphaFoldDB; P44395; -.
DR   SMR; P44395; -.
DR   STRING; 71421.HI_0537; -.
DR   EnsemblBacteria; AAC22195; AAC22195; HI_0537.
DR   KEGG; hin:HI_0537; -.
DR   PATRIC; fig|71421.8.peg.556; -.
DR   eggNOG; COG0830; Bacteria.
DR   HOGENOM; CLU_049215_4_1_6; -.
DR   PhylomeDB; P44395; -.
DR   BioCyc; HINF71421:G1GJ1-550-MON; -.
DR   Proteomes; UP000000579; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016151; F:nickel cation binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006807; P:nitrogen compound metabolic process; IEA:InterPro.
DR   Gene3D; 1.10.4190.10; -; 1.
DR   HAMAP; MF_01385; UreF; 1.
DR   InterPro; IPR002639; UreF.
DR   InterPro; IPR038277; UreF_sf.
DR   Pfam; PF01730; UreF; 1.
DR   PIRSF; PIRSF009467; Ureas_acces_UreF; 1.
PE   3: Inferred from homology;
KW   Chaperone; Cytoplasm; Nickel insertion; Reference proteome.
FT   CHAIN           1..235
FT                   /note="Urease accessory protein UreF"
FT                   /id="PRO_0000067647"
SQ   SEQUENCE   235 AA;  26386 MW;  38C923A64E5B0E73 CRC64;
     MAQTLNRSLT DLGALLHLVD PTLPIGGFNH SNGLETFVQQ RVVESKATLE EYVQTQLLQN
     WIYNDGAYLS LAFDAMCEGN FDRLCELDWQ LSATKVARES REGSFKLGVR LLKIFIRYET
     HTLLTAYQQA IAEKRVQGYF PIVFAMVAQA MGLSKADTLY AFYYNAAVGV ITNGVKLIPL
     SQMDGQDILF DLRGSLVQAV ELSLDPDEEW LGAATLANDI RAMQHEVLYT RLYMS