UREF_STAA8
ID UREF_STAA8 Reviewed; 229 AA.
AC Q2G2K7;
DT 22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 21-MAR-2006, sequence version 1.
DT 25-MAY-2022, entry version 81.
DE RecName: Full=Urease accessory protein UreF {ECO:0000255|HAMAP-Rule:MF_01385};
GN Name=ureF {ECO:0000255|HAMAP-Rule:MF_01385};
GN OrderedLocusNames=SAOUHSC_02563;
OS Staphylococcus aureus (strain NCTC 8325 / PS 47).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=93061;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCTC 8325 / PS 47;
RA Gillaspy A.F., Worrell V., Orvis J., Roe B.A., Dyer D.W., Iandolo J.J.;
RT "The Staphylococcus aureus NCTC 8325 genome.";
RL (In) Fischetti V., Novick R., Ferretti J., Portnoy D., Rood J. (eds.);
RL Gram positive pathogens, 2nd edition, pp.381-412, ASM Press, Washington
RL D.C. (2006).
CC -!- FUNCTION: Required for maturation of urease via the functional
CC incorporation of the urease nickel metallocenter. {ECO:0000255|HAMAP-
CC Rule:MF_01385}.
CC -!- SUBUNIT: UreD, UreF and UreG form a complex that acts as a GTP-
CC hydrolysis-dependent molecular chaperone, activating the urease
CC apoprotein by helping to assemble the nickel containing metallocenter
CC of UreC. The UreE protein probably delivers the nickel.
CC {ECO:0000255|HAMAP-Rule:MF_01385}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01385}.
CC -!- SIMILARITY: Belongs to the UreF family. {ECO:0000255|HAMAP-
CC Rule:MF_01385}.
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DR EMBL; CP000253; ABD31575.1; -; Genomic_DNA.
DR RefSeq; WP_000565255.1; NZ_LS483365.1.
DR RefSeq; YP_501024.1; NC_007795.1.
DR AlphaFoldDB; Q2G2K7; -.
DR SMR; Q2G2K7; -.
DR STRING; 1280.SAXN108_2540; -.
DR EnsemblBacteria; ABD31575; ABD31575; SAOUHSC_02563.
DR GeneID; 3921560; -.
DR KEGG; sao:SAOUHSC_02563; -.
DR PATRIC; fig|93061.5.peg.2312; -.
DR eggNOG; COG0830; Bacteria.
DR HOGENOM; CLU_049215_4_2_9; -.
DR OMA; TQYTRLF; -.
DR PRO; PR:Q2G2K7; -.
DR Proteomes; UP000008816; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016151; F:nickel cation binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006807; P:nitrogen compound metabolic process; IEA:InterPro.
DR Gene3D; 1.10.4190.10; -; 1.
DR HAMAP; MF_01385; UreF; 1.
DR InterPro; IPR002639; UreF.
DR InterPro; IPR038277; UreF_sf.
DR Pfam; PF01730; UreF; 1.
DR PIRSF; PIRSF009467; Ureas_acces_UreF; 1.
PE 3: Inferred from homology;
KW Chaperone; Cytoplasm; Nickel insertion; Reference proteome.
FT CHAIN 1..229
FT /note="Urease accessory protein UreF"
FT /id="PRO_0000344189"
SQ SEQUENCE 229 AA; 26480 MW; 880A5E967E6AB2D4 CRC64;
MIDHTHLRLF QFCDSQFPTG AFSHSFGLET YIQRNIIHDD HTFIAWLKMF LQEQLTYSDG
LAMRLVYDAL ENDDTQKVLH IDKLMFVQNL PKETRVGAKQ MGTRMVKLAL ELYNSPWIAW
YHQQMQDKKA KLNPAICFTM LGHHLGVDIE TIIDYYLYQN VSSLTQNAVR AIPLGQTAGQ
KIVTHMIPYI EGTRKQIFEL KEADFGMTAP GLELNQMAHE NVNVRIFIS