UREF_STAA9
ID UREF_STAA9 Reviewed; 229 AA.
AC A5IV73;
DT 22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 26-JUN-2007, sequence version 1.
DT 25-MAY-2022, entry version 69.
DE RecName: Full=Urease accessory protein UreF {ECO:0000255|HAMAP-Rule:MF_01385};
GN Name=ureF {ECO:0000255|HAMAP-Rule:MF_01385};
GN OrderedLocusNames=SaurJH9_2316;
OS Staphylococcus aureus (strain JH9).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=359786;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JH9;
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA Glavina del Rio T., Hammon N., Israni S., Pitluck S., Chain P.,
RA Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M.,
RA Hauser L., Kyrpides N., Kim E., Tomasz A., Richardson P.;
RT "Complete sequence of chromosome of Staphylococcus aureus subsp. aureus
RT JH9.";
RL Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Required for maturation of urease via the functional
CC incorporation of the urease nickel metallocenter. {ECO:0000255|HAMAP-
CC Rule:MF_01385}.
CC -!- SUBUNIT: UreD, UreF and UreG form a complex that acts as a GTP-
CC hydrolysis-dependent molecular chaperone, activating the urease
CC apoprotein by helping to assemble the nickel containing metallocenter
CC of UreC. The UreE protein probably delivers the nickel.
CC {ECO:0000255|HAMAP-Rule:MF_01385}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01385}.
CC -!- SIMILARITY: Belongs to the UreF family. {ECO:0000255|HAMAP-
CC Rule:MF_01385}.
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DR EMBL; CP000703; ABQ50096.1; -; Genomic_DNA.
DR RefSeq; WP_000565254.1; NC_009487.1.
DR AlphaFoldDB; A5IV73; -.
DR SMR; A5IV73; -.
DR KEGG; saj:SaurJH9_2316; -.
DR HOGENOM; CLU_049215_4_2_9; -.
DR OMA; TQYTRLF; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016151; F:nickel cation binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006807; P:nitrogen compound metabolic process; IEA:InterPro.
DR Gene3D; 1.10.4190.10; -; 1.
DR HAMAP; MF_01385; UreF; 1.
DR InterPro; IPR002639; UreF.
DR InterPro; IPR038277; UreF_sf.
DR Pfam; PF01730; UreF; 1.
DR PIRSF; PIRSF009467; Ureas_acces_UreF; 1.
PE 3: Inferred from homology;
KW Chaperone; Cytoplasm; Nickel insertion.
FT CHAIN 1..229
FT /note="Urease accessory protein UreF"
FT /id="PRO_0000344182"
SQ SEQUENCE 229 AA; 26552 MW; D20A5E967E69E4E1 CRC64;
MIDHTHLRLF QFCDSQFPTG AFSHSFGLET YIQRNIIHDD HTFIAWLKMF LQEQLTYSDG
LAMRLVYDAL ENDDTQKVLH IDKLMFVQNL PKETRVGAKQ MGTRMVKLAL ELYNSPWIAW
YHQQMQDKKA KLNPAICFTM LGHHLGVDIE TIIDYYLYQN VSSLTQNAVR AIPLGQTAGQ
KIVTHMIPYI EETRKQIFEL KEADFGMTAP GLELNQMAHE NVNVRIFIS