ID   CADC_LISIN              Reviewed;         119 AA.
AC   P0A4U2; P94887;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=Cadmium resistance transcriptional regulatory protein CadC;
DE   AltName: Full=Cadmium efflux system accessory protein;
GN   Name=cadC; OrderedLocusNames=pli0060;
OS   Listeria innocua serovar 6a (strain ATCC BAA-680 / CLIP 11262).
OG   Plasmid pLI100.
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Listeriaceae; Listeria.
OX   NCBI_TaxID=272626;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-680 / CLIP 11262;
RX   PubMed=11679669; DOI=10.1126/science.1063447;
RA   Glaser P., Frangeul L., Buchrieser C., Rusniok C., Amend A., Baquero F.,
RA   Berche P., Bloecker H., Brandt P., Chakraborty T., Charbit A.,
RA   Chetouani F., Couve E., de Daruvar A., Dehoux P., Domann E.,
RA   Dominguez-Bernal G., Duchaud E., Durant L., Dussurget O., Entian K.-D.,
RA   Fsihi H., Garcia-del Portillo F., Garrido P., Gautier L., Goebel W.,
RA   Gomez-Lopez N., Hain T., Hauf J., Jackson D., Jones L.-M., Kaerst U.,
RA   Kreft J., Kuhn M., Kunst F., Kurapkat G., Madueno E., Maitournam A.,
RA   Mata Vicente J., Ng E., Nedjari H., Nordsiek G., Novella S., de Pablos B.,
RA   Perez-Diaz J.-C., Purcell R., Remmel B., Rose M., Schlueter T., Simoes N.,
RA   Tierrez A., Vazquez-Boland J.-A., Voss H., Wehland J., Cossart P.;
RT   "Comparative genomics of Listeria species.";
RL   Science 294:849-852(2001).
CC   -!- FUNCTION: Metal-binding repressor for the cad operon. Involved in
CC       resistance to heavy metals, such as cadmium, bismuth, zinc or lead.
CC       Metal binding causes the repressor to dissociate from the DNA (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
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DR   EMBL; AL592102; CAC42058.1; -; Genomic_DNA.
DR   RefSeq; WP_003726380.1; NC_003383.1.
DR   AlphaFoldDB; P0A4U2; -.
DR   SMR; P0A4U2; -.
DR   STRING; 272626.pli0060; -.
DR   EnsemblBacteria; CAC42058; CAC42058; CAC42058.
DR   KEGG; lin:pli0060; -.
DR   eggNOG; COG0640; Bacteria.
DR   HOGENOM; CLU_097806_7_3_9; -.
DR   OMA; HKQGIVK; -.
DR   OrthoDB; 1772343at2; -.
DR   Proteomes; UP000002513; Plasmid pLI100.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0046686; P:response to cadmium ion; IEA:UniProtKB-KW.
DR   CDD; cd00090; HTH_ARSR; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR011991; ArsR-like_HTH.
DR   InterPro; IPR018334; ArsR_HTH.
DR   InterPro; IPR001845; HTH_ArsR_DNA-bd_dom.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF01022; HTH_5; 1.
DR   PRINTS; PR00778; HTHARSR.
DR   SMART; SM00418; HTH_ARSR; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS00846; HTH_ARSR_1; 1.
DR   PROSITE; PS50987; HTH_ARSR_2; 1.
PE   3: Inferred from homology;
KW   Cadmium; Cadmium resistance; DNA-binding; Metal-binding; Plasmid;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..119
FT                   /note="Cadmium resistance transcriptional regulatory
FT                   protein CadC"
FT                   /id="PRO_0000160618"
FT   DOMAIN          23..118
FT                   /note="HTH arsR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00340"
FT   DNA_BIND        58..77
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00340"
FT   BINDING         6
FT                   /ligand="Cd(2+)"
FT                   /ligand_id="ChEBI:CHEBI:48775"
FT                   /ligand_note="ligand shared between dimeric partners"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00340"
FT   BINDING         10
FT                   /ligand="Cd(2+)"
FT                   /ligand_id="ChEBI:CHEBI:48775"
FT                   /ligand_note="ligand shared between dimeric partners"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00340"
FT   BINDING         57
FT                   /ligand="Cd(2+)"
FT                   /ligand_id="ChEBI:CHEBI:48775"
FT                   /ligand_note="ligand shared between dimeric partners"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00340"
FT   BINDING         59
FT                   /ligand="Cd(2+)"
FT                   /ligand_id="ChEBI:CHEBI:48775"
FT                   /ligand_note="ligand shared between dimeric partners"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00340"
SQ   SEQUENCE   119 AA;  13382 MW;  B34C01C21DC2C944 CRC64;
     MNNEICEITC IHEDKVNRAK SKLANFDTPS VSGFFKILSD ENRLKIVHAL VHEDELCVCD
     IANIIDASVA TTSHHLNSLK KLGVVDSHKD GKLVYYFIKN IKILNLMELG VNFKEEVLA