ID   UREF_STAES              Reviewed;         229 AA.
AC   Q8CNC7;
DT   22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   25-MAY-2022, entry version 87.
DE   RecName: Full=Urease accessory protein UreF {ECO:0000255|HAMAP-Rule:MF_01385};
GN   Name=ureF {ECO:0000255|HAMAP-Rule:MF_01385}; OrderedLocusNames=SE_1865;
OS   Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=176280;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 12228 / FDA PCI 1200;
RX   PubMed=12950922; DOI=10.1046/j.1365-2958.2003.03671.x;
RA   Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J., Qin Z.-Q.,
RA   Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z., Yuan Z.-H.,
RA   Zhao G.-P., Qu D., Danchin A., Wen Y.-M.;
RT   "Genome-based analysis of virulence genes in a non-biofilm-forming
RT   Staphylococcus epidermidis strain (ATCC 12228).";
RL   Mol. Microbiol. 49:1577-1593(2003).
CC   -!- FUNCTION: Required for maturation of urease via the functional
CC       incorporation of the urease nickel metallocenter. {ECO:0000255|HAMAP-
CC       Rule:MF_01385}.
CC   -!- SUBUNIT: UreD, UreF and UreG form a complex that acts as a GTP-
CC       hydrolysis-dependent molecular chaperone, activating the urease
CC       apoprotein by helping to assemble the nickel containing metallocenter
CC       of UreC. The UreE protein probably delivers the nickel.
CC       {ECO:0000255|HAMAP-Rule:MF_01385}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01385}.
CC   -!- SIMILARITY: Belongs to the UreF family. {ECO:0000255|HAMAP-
CC       Rule:MF_01385}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE015929; AAO05506.1; -; Genomic_DNA.
DR   RefSeq; NP_765420.1; NC_004461.1.
DR   RefSeq; WP_001832407.1; NZ_WBME01000034.1.
DR   AlphaFoldDB; Q8CNC7; -.
DR   SMR; Q8CNC7; -.
DR   STRING; 176280.SE_1865; -.
DR   PRIDE; Q8CNC7; -.
DR   EnsemblBacteria; AAO05506; AAO05506; SE_1865.
DR   KEGG; sep:SE_1865; -.
DR   PATRIC; fig|176280.10.peg.1822; -.
DR   eggNOG; COG0830; Bacteria.
DR   HOGENOM; CLU_049215_4_2_9; -.
DR   OMA; TQYTRLF; -.
DR   Proteomes; UP000001411; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016151; F:nickel cation binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006807; P:nitrogen compound metabolic process; IEA:InterPro.
DR   Gene3D; 1.10.4190.10; -; 1.
DR   HAMAP; MF_01385; UreF; 1.
DR   InterPro; IPR002639; UreF.
DR   InterPro; IPR038277; UreF_sf.
DR   Pfam; PF01730; UreF; 1.
DR   PIRSF; PIRSF009467; Ureas_acces_UreF; 1.
PE   3: Inferred from homology;
KW   Chaperone; Cytoplasm; Nickel insertion.
FT   CHAIN           1..229
FT                   /note="Urease accessory protein UreF"
FT                   /id="PRO_0000344193"
SQ   SEQUENCE   229 AA;  26717 MW;  8CF167470DA60284 CRC64;
     MIDHQHLRLF QFCDSQFPTG AFSHSFGLET YIQRETVHDT ETFIKWLHLF INEQLTYSDG
     IAMRIVYHAL INNDKDKILD INQKLFVQNL PKETRIGAKQ MGTRMVKLAL DLYDSEWIQW
     YYNQMKNNKI KLHPAVCFTM LGHFLGVDVE SIIDYYLYQN ISSLTQNAVR AIPLGQTAGQ
     QVVTEMIAHI EKTRNHILEL DEIDFGMTAP GLELNQMEHE NVHVRIFIS