ID   CADC_LISMN              Reviewed;         119 AA.
AC   Q56405;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 111.
DE   RecName: Full=Cadmium resistance transcriptional regulatory protein CadC;
DE   AltName: Full=Cadmium efflux system accessory protein;
GN   Name=cadC;
OS   Listeria monocytogenes.
OG   Plasmid pLm74.
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Listeriaceae; Listeria.
OX   NCBI_TaxID=1639;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=LM74;
RX   PubMed=8188605; DOI=10.1128/jb.176.10.3040-3048.1994;
RA   Lebrun M., Audurier A., Cossart P.;
RT   "Plasmid-borne cadmium resistance genes in Listeria monocytogenes are
RT   similar to cadA and cadC of Staphylococcus aureus and are induced by
RT   cadmium.";
RL   J. Bacteriol. 176:3040-3048(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=LM74; TRANSPOSON=Tn5422;
RX   PubMed=8188606; DOI=10.1128/jb.176.10.3049-3061.1994;
RA   Lebrun M., Audurier A., Cossart P.;
RT   "Plasmid-borne cadmium resistance genes in Listeria monocytogenes are
RT   present on Tn5422, a novel transposon closely related to Tn917.";
RL   J. Bacteriol. 176:3049-3061(1994).
CC   -!- FUNCTION: Metal-binding repressor for the cad operon. Involved in
CC       resistance to heavy metals, such as cadmium, bismuth, zinc or lead.
CC       Metal binding causes the repressor to dissociate from the DNA (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
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DR   EMBL; L28104; AAA25276.1; -; Genomic_DNA.
DR   RefSeq; WP_003728467.1; NZ_WUEB01000010.1.
DR   RefSeq; YP_003728019.1; NC_014255.1.
DR   AlphaFoldDB; Q56405; -.
DR   SMR; Q56405; -.
DR   PHI-base; PHI:7387; -.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0046686; P:response to cadmium ion; IEA:UniProtKB-KW.
DR   CDD; cd00090; HTH_ARSR; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR011991; ArsR-like_HTH.
DR   InterPro; IPR018334; ArsR_HTH.
DR   InterPro; IPR001845; HTH_ArsR_DNA-bd_dom.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF01022; HTH_5; 1.
DR   PRINTS; PR00778; HTHARSR.
DR   SMART; SM00418; HTH_ARSR; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS00846; HTH_ARSR_1; 1.
DR   PROSITE; PS50987; HTH_ARSR_2; 1.
PE   3: Inferred from homology;
KW   Cadmium; Cadmium resistance; DNA-binding; Metal-binding; Plasmid;
KW   Transcription; Transcription regulation; Transposable element.
FT   CHAIN           1..119
FT                   /note="Cadmium resistance transcriptional regulatory
FT                   protein CadC"
FT                   /id="PRO_0000160619"
FT   DOMAIN          23..118
FT                   /note="HTH arsR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00340"
FT   DNA_BIND        58..77
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00340"
FT   BINDING         6
FT                   /ligand="Cd(2+)"
FT                   /ligand_id="ChEBI:CHEBI:48775"
FT                   /ligand_note="ligand shared between dimeric partners"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00340"
FT   BINDING         10
FT                   /ligand="Cd(2+)"
FT                   /ligand_id="ChEBI:CHEBI:48775"
FT                   /ligand_note="ligand shared between dimeric partners"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00340"
FT   BINDING         57
FT                   /ligand="Cd(2+)"
FT                   /ligand_id="ChEBI:CHEBI:48775"
FT                   /ligand_note="ligand shared between dimeric partners"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00340"
FT   BINDING         59
FT                   /ligand="Cd(2+)"
FT                   /ligand_id="ChEBI:CHEBI:48775"
FT                   /ligand_note="ligand shared between dimeric partners"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00340"
SQ   SEQUENCE   119 AA;  13489 MW;  040D3AC8085A4EE1 CRC64;
     MTVDICEITC IDEEKVKRVK TGLETVEVTT ISQIFKILSD ETRVKIVYAL LTENELCVCD
     LANIVEATVA ATSHHLRFLK KQGIANYRKD GKLVYYSLAN ERVRDRIKLI LLNFEGVGV