ID   UREF_UREPA              Reviewed;         235 AA.
AC   Q56560; Q9PQ58;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   22-JUL-2008, sequence version 3.
DT   25-MAY-2022, entry version 96.
DE   RecName: Full=Urease accessory protein UreF {ECO:0000255|HAMAP-Rule:MF_01385};
GN   Name=ureF {ECO:0000255|HAMAP-Rule:MF_01385}; OrderedLocusNames=UU430;
OS   Ureaplasma parvum serovar 3 (strain ATCC 700970).
OC   Bacteria; Tenericutes; Mollicutes; Mycoplasmataceae; Ureaplasma.
OX   NCBI_TaxID=273119;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 27813 / 7 / Serovar 1;
RX   PubMed=8550495; DOI=10.1128/jb.178.3.647-655.1996;
RA   Neyrolles O., Ferris S., Behbahani N., Montagnier L., Blanchard A.;
RT   "Organization of Ureaplasma urealyticum urease gene cluster and expression
RT   in a suppressor strain of Escherichia coli.";
RL   J. Bacteriol. 178:647-655(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700970;
RX   PubMed=11048724; DOI=10.1038/35037619;
RA   Glass J.I., Lefkowitz E.J., Glass J.S., Heiner C.R., Chen E.Y.,
RA   Cassell G.H.;
RT   "The complete sequence of the mucosal pathogen Ureaplasma urealyticum.";
RL   Nature 407:757-762(2000).
CC   -!- FUNCTION: Required for maturation of urease via the functional
CC       incorporation of the urease nickel metallocenter. {ECO:0000255|HAMAP-
CC       Rule:MF_01385}.
CC   -!- SUBUNIT: UreD, UreF and UreG form a complex that acts as a GTP-
CC       hydrolysis-dependent molecular chaperone, activating the urease
CC       apoprotein by helping to assemble the nickel containing metallocenter
CC       of UreC. The UreE protein probably delivers the nickel.
CC       {ECO:0000255|HAMAP-Rule:MF_01385}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01385}.
CC   -!- SIMILARITY: Belongs to the UreF family. {ECO:0000255|HAMAP-
CC       Rule:MF_01385}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAA89191.2; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=AAF30842.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; L40489; AAA89191.2; ALT_INIT; Genomic_DNA.
DR   EMBL; AF222894; AAF30842.1; ALT_INIT; Genomic_DNA.
DR   PIR; E82890; E82890.
DR   RefSeq; WP_006689006.1; NC_002162.1.
DR   AlphaFoldDB; Q56560; -.
DR   SMR; Q56560; -.
DR   STRING; 273119.UU430; -.
DR   EnsemblBacteria; AAF30842; AAF30842; UU430.
DR   GeneID; 29672335; -.
DR   KEGG; uur:UU430; -.
DR   eggNOG; COG0830; Bacteria.
DR   HOGENOM; CLU_049215_4_2_14; -.
DR   OMA; TQYTRLF; -.
DR   Proteomes; UP000000423; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016151; F:nickel cation binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006807; P:nitrogen compound metabolic process; IEA:InterPro.
DR   Gene3D; 1.10.4190.10; -; 1.
DR   HAMAP; MF_01385; UreF; 1.
DR   InterPro; IPR002639; UreF.
DR   InterPro; IPR038277; UreF_sf.
DR   Pfam; PF01730; UreF; 1.
DR   PIRSF; PIRSF009467; Ureas_acces_UreF; 1.
PE   3: Inferred from homology;
KW   Chaperone; Cytoplasm; Nickel insertion; Reference proteome.
FT   CHAIN           1..235
FT                   /note="Urease accessory protein UreF"
FT                   /id="PRO_0000067656"
FT   CONFLICT        24
FT                   /note="G -> R (in Ref. 1; AAA89191)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        88..101
FT                   /note="MINFQGLARETREG -> SDKLSRFSKRDSLKV (in Ref. 1;
FT                   AAA89191)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        206..235
FT                   /note="DFKTDFCKNIPGLEIAQMEHEDTPVRLFMS -> ILKQIFAKIYQALKLPNG
FT                   TLRHTCSIVHVIIKVLVKHYINHKNTILIFLENLKKKEN (in Ref. 1;
FT                   AAA89191)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   235 AA;  27147 MW;  74D82BF245BD6603 CRC64;
     MTLNSDYLNL LDLMQITNAN FPIGTFSHSF GVETYIRKDI VFDGESLIKA LLLYMNEQLL
     HGDLLAIYQI FKLLPKQKIN AIWEIDQMIN FQGLARETRE GQRRIGQQMV KIYNELFNCE
     LLVEYAERIK NKKSYGNPAV AFALLAMHLK IDLKTALYTH LYSTVAALTQ NCVRAIPLGQ
     VKGQKIIYQL KHVYFDDIVN KVFTLDFKTD FCKNIPGLEI AQMEHEDTPV RLFMS