ID   UREF_UREU1              Reviewed;         235 AA.
AC   B5ZBS7;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   25-NOV-2008, sequence version 1.
DT   25-MAY-2022, entry version 60.
DE   RecName: Full=Urease accessory protein UreF {ECO:0000255|HAMAP-Rule:MF_01385};
GN   Name=ureF {ECO:0000255|HAMAP-Rule:MF_01385}; OrderedLocusNames=UUR10_0475;
OS   Ureaplasma urealyticum serovar 10 (strain ATCC 33699 / Western).
OC   Bacteria; Tenericutes; Mollicutes; Mycoplasmataceae; Ureaplasma.
OX   NCBI_TaxID=565575;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 33699 / Western;
RA   Shrivastava S., Methe B.A., Glass J., White K., Duffy L.B.;
RT   "Genome sequence of Ureaplasma urealyticum serovar 10 ATCC-33699.";
RL   Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for maturation of urease via the functional
CC       incorporation of the urease nickel metallocenter. {ECO:0000255|HAMAP-
CC       Rule:MF_01385}.
CC   -!- SUBUNIT: UreD, UreF and UreG form a complex that acts as a GTP-
CC       hydrolysis-dependent molecular chaperone, activating the urease
CC       apoprotein by helping to assemble the nickel containing metallocenter
CC       of UreC. The UreE protein probably delivers the nickel.
CC       {ECO:0000255|HAMAP-Rule:MF_01385}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01385}.
CC   -!- SIMILARITY: Belongs to the UreF family. {ECO:0000255|HAMAP-
CC       Rule:MF_01385}.
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DR   EMBL; CP001184; ACI60022.1; -; Genomic_DNA.
DR   RefSeq; WP_004025843.1; NC_011374.1.
DR   AlphaFoldDB; B5ZBS7; -.
DR   SMR; B5ZBS7; -.
DR   STRING; 565575.UUR10_0475; -.
DR   EnsemblBacteria; ACI60022; ACI60022; UUR10_0475.
DR   GeneID; 45016018; -.
DR   KEGG; uue:UUR10_0475; -.
DR   eggNOG; COG0830; Bacteria.
DR   HOGENOM; CLU_049215_4_2_14; -.
DR   OMA; TQYTRLF; -.
DR   OrthoDB; 1942614at2; -.
DR   Proteomes; UP000002018; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016151; F:nickel cation binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006807; P:nitrogen compound metabolic process; IEA:InterPro.
DR   Gene3D; 1.10.4190.10; -; 1.
DR   HAMAP; MF_01385; UreF; 1.
DR   InterPro; IPR002639; UreF.
DR   InterPro; IPR038277; UreF_sf.
DR   Pfam; PF01730; UreF; 1.
DR   PIRSF; PIRSF009467; Ureas_acces_UreF; 1.
PE   3: Inferred from homology;
KW   Chaperone; Cytoplasm; Nickel insertion.
FT   CHAIN           1..235
FT                   /note="Urease accessory protein UreF"
FT                   /id="PRO_1000145143"
SQ   SEQUENCE   235 AA;  27209 MW;  EE33AF1BC8A447F8 CRC64;
     MMLNSDYLNL LDLMQITNAN FPIGTFSHSF GIETYIRKDI VFDGDSLIRA LLLYMNEQLL
     HGDLLAIYQI FKLLPKQKIN AIWEIDQMIN FQGLARETRE GQRRIGQQMV KIYNELFDCE
     LLVEYAQRIK DRKSYGNPAV AFALLAMHLK IDLKTALYTH LYSTVAALTQ NCVRAIPLGQ
     VKGQKIIHKL KHVYFDDIID KVFSLDFKTD FCKNIPGLEI AQMEHEDTPV RLFMS