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UREF_YERPS
ID   UREF_YERPS              Reviewed;         228 AA.
AC   P52318; Q667Q2;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   11-JUL-2001, sequence version 2.
DT   25-MAY-2022, entry version 90.
DE   RecName: Full=Urease accessory protein UreF {ECO:0000255|HAMAP-Rule:MF_01385};
GN   Name=ureF {ECO:0000255|HAMAP-Rule:MF_01385}; OrderedLocusNames=YPTB2940;
OS   Yersinia pseudotuberculosis serotype I (strain IP32953).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Yersinia.
OX   NCBI_TaxID=273123;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=IP 2777;
RX   PubMed=9125594; DOI=10.1128/iai.65.5.1985-1990.1997;
RA   Riot B., Berche P., Simonet M.;
RT   "Urease is not involved in the virulence of Yersinia pseudotuberculosis in
RT   mice.";
RL   Infect. Immun. 65:1985-1990(1997).
RN   [2]
RP   SEQUENCE REVISION TO 5-9 AND 168-171.
RA   Riot B.;
RL   Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IP32953;
RX   PubMed=15358858; DOI=10.1073/pnas.0404012101;
RA   Chain P.S.G., Carniel E., Larimer F.W., Lamerdin J., Stoutland P.O.,
RA   Regala W.M., Georgescu A.M., Vergez L.M., Land M.L., Motin V.L.,
RA   Brubaker R.R., Fowler J., Hinnebusch J., Marceau M., Medigue C.,
RA   Simonet M., Chenal-Francisque V., Souza B., Dacheux D., Elliott J.M.,
RA   Derbise A., Hauser L.J., Garcia E.;
RT   "Insights into the evolution of Yersinia pestis through whole-genome
RT   comparison with Yersinia pseudotuberculosis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:13826-13831(2004).
CC   -!- FUNCTION: Required for maturation of urease via the functional
CC       incorporation of the urease nickel metallocenter. {ECO:0000255|HAMAP-
CC       Rule:MF_01385}.
CC   -!- SUBUNIT: UreD, UreF and UreG form a complex that acts as a GTP-
CC       hydrolysis-dependent molecular chaperone, activating the urease
CC       apoprotein by helping to assemble the nickel containing metallocenter
CC       of UreC. The UreE protein probably delivers the nickel.
CC       {ECO:0000255|HAMAP-Rule:MF_01385}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01385}.
CC   -!- SIMILARITY: Belongs to the UreF family. {ECO:0000255|HAMAP-
CC       Rule:MF_01385}.
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DR   EMBL; U40842; AAA87856.2; -; Genomic_DNA.
DR   EMBL; BX936398; CAH22178.1; -; Genomic_DNA.
DR   RefSeq; WP_011192843.1; NZ_CP009712.1.
DR   AlphaFoldDB; P52318; -.
DR   SMR; P52318; -.
DR   EnsemblBacteria; CAH22178; CAH22178; YPTB2940.
DR   GeneID; 66844636; -.
DR   KEGG; ypo:BZ17_3688; -.
DR   KEGG; yps:YPTB2940; -.
DR   PATRIC; fig|273123.14.peg.3866; -.
DR   OMA; HVRLFMN; -.
DR   Proteomes; UP000001011; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016151; F:nickel cation binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006807; P:nitrogen compound metabolic process; IEA:InterPro.
DR   Gene3D; 1.10.4190.10; -; 1.
DR   HAMAP; MF_01385; UreF; 1.
DR   InterPro; IPR002639; UreF.
DR   InterPro; IPR038277; UreF_sf.
DR   Pfam; PF01730; UreF; 1.
DR   PIRSF; PIRSF009467; Ureas_acces_UreF; 1.
PE   3: Inferred from homology;
KW   Chaperone; Cytoplasm; Nickel insertion.
FT   CHAIN           1..228
FT                   /note="Urease accessory protein UreF"
FT                   /id="PRO_0000067659"
SQ   SEQUENCE   228 AA;  25009 MW;  212D225507D42E67 CRC64;
     MNASDLIRIM QFGDSVLPVG AFTFSNGVES AIQTGIVHDV ATLKGFVLTA LKQAASCDGM
     GVVAAHRAVV ADDRDGIIRA DWAVNNRKLN EESRLMATRM GKKLAEMSIH VVEHPLISWW
     LEQIKNGNTA GTYPVTQAVV MAAQGIGQRE VVVMHQYGVA MTILSAAMRL MRVTHFDTQH
     ILFELNHDIE KFCDIAEIGD INQMSSYVPI VDVLAAVHVK AHVRLFSN
 
 
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