ID   CADF1_PLAF7             Reviewed;         122 AA.
AC   Q8I467;
DT   16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=Cofilin/actin-depolymerizing factor homolog 1 {ECO:0000250|UniProtKB:P86292};
GN   ORFNames=PFE0165w;
OS   Plasmodium falciparum (isolate 3D7).
OC   Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX   NCBI_TaxID=36329;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=3D7;
RX   PubMed=12368864; DOI=10.1038/nature01097;
RA   Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA   Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.D.,
RA   Eisen J.A., Rutherford K.M., Salzberg S.L., Craig A., Kyes S., Chan M.-S.,
RA   Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M.,
RA   Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M.A.,
RA   Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I.,
RA   Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J.,
RA   Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B.G.;
RT   "Genome sequence of the human malaria parasite Plasmodium falciparum.";
RL   Nature 419:498-511(2002).
RN   [2] {ECO:0000312|EMBL:CAD51399.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=3D7;
RX   PubMed=12368867; DOI=10.1038/nature01095;
RA   Hall N., Pain A., Berriman M., Churcher C.M., Harris B., Harris D.,
RA   Mungall K.L., Bowman S., Atkin R., Baker S., Barron A., Brooks K.,
RA   Buckee C.O., Burrows C., Cherevach I., Chillingworth C., Chillingworth T.,
RA   Christodoulou Z., Clark L., Clark R., Corton C., Cronin A., Davies R.M.,
RA   Davis P., Dear P., Dearden F., Doggett J., Feltwell T., Goble A.,
RA   Goodhead I., Gwilliam R., Hamlin N., Hance Z., Harper D., Hauser H.,
RA   Hornsby T., Holroyd S., Horrocks P., Humphray S., Jagels K., James K.D.,
RA   Johnson D., Kerhornou A., Knights A., Konfortov B., Kyes S., Larke N.,
RA   Lawson D., Lennard N., Line A., Maddison M., Mclean J., Mooney P.,
RA   Moule S., Murphy L., Oliver K., Ormond D., Price C., Quail M.A.,
RA   Rabbinowitsch E., Rajandream M.A., Rutter S., Rutherford K.M., Sanders M.,
RA   Simmonds M., Seeger K., Sharp S., Smith R., Squares R., Squares S.,
RA   Stevens K., Taylor K., Tivey A., Unwin L., Whitehead S., Woodward J.R.,
RA   Sulston J.E., Craig A., Newbold C., Barrell B.G.;
RT   "Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.";
RL   Nature 419:527-531(2002).
CC   -!- FUNCTION: Not involved in actin polymerisation, instead functions to
CC       stimulate nucleotide exchange on monomeric actin and influence turnover
CC       of the small amount of cytosolic actin microfilaments. Essential for
CC       erythrocytic schizogony (By similarity).
CC       {ECO:0000250|UniProtKB:P86292}.
CC   -!- SUBUNIT: Interacts with monomeric actin, does not bind to actin
CC       polymers. {ECO:0000250|UniProtKB:P86292}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q03048}.
CC       Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q03048}.
CC   -!- SIMILARITY: Belongs to the actin-binding proteins ADF family.
CC       {ECO:0000255}.
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DR   EMBL; AL844504; CAD51399.1; -; Genomic_DNA.
DR   RefSeq; XP_001351592.1; XM_001351556.1.
DR   PDB; 2XF1; X-ray; 1.96 A; A=1-122.
DR   PDBsum; 2XF1; -.
DR   AlphaFoldDB; Q8I467; -.
DR   SMR; Q8I467; -.
DR   STRING; 5833.PFE0165w; -.
DR   PRIDE; Q8I467; -.
DR   EnsemblProtists; CAD51399; CAD51399; PF3D7_0503400.
DR   GeneID; 812927; -.
DR   KEGG; pfa:PF3D7_0503400; -.
DR   VEuPathDB; PlasmoDB:PF3D7_0503400; -.
DR   HOGENOM; CLU_094004_3_2_1; -.
DR   InParanoid; Q8I467; -.
DR   OMA; NKIHFFM; -.
DR   PhylomeDB; Q8I467; -.
DR   EvolutionaryTrace; Q8I467; -.
DR   Proteomes; UP000001450; Chromosome 5.
DR   GO; GO:0015629; C:actin cytoskeleton; IDA:GeneDB.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005829; C:cytosol; IDA:GeneDB.
DR   GO; GO:0051015; F:actin filament binding; IBA:GO_Central.
DR   GO; GO:0003785; F:actin monomer binding; IDA:GeneDB.
DR   GO; GO:0030036; P:actin cytoskeleton organization; IDA:GeneDB.
DR   GO; GO:0030042; P:actin filament depolymerization; IBA:GO_Central.
DR   GO; GO:0051014; P:actin filament severing; IDA:GeneDB.
DR   GO; GO:0060327; P:cytoplasmic actin-based contraction involved in cell motility; IDA:GeneDB.
DR   Gene3D; 3.40.20.10; -; 1.
DR   InterPro; IPR002108; ADF-H.
DR   InterPro; IPR029006; ADF-H/Gelsolin-like_dom_sf.
DR   InterPro; IPR017904; ADF/Cofilin.
DR   PANTHER; PTHR11913; PTHR11913; 1.
DR   Pfam; PF00241; Cofilin_ADF; 1.
DR   SMART; SM00102; ADF; 1.
DR   PROSITE; PS51263; ADF_H; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Actin-binding; Cytoplasm; Cytoskeleton; Reference proteome.
FT   CHAIN           1..122
FT                   /note="Cofilin/actin-depolymerizing factor homolog 1"
FT                   /id="PRO_0000377706"
FT   DOMAIN          4..122
FT                   /note="ADF-H"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00599"
SQ   SEQUENCE   122 AA;  13741 MW;  F746935229AFDD25 CRC64;
     MISGIRVNDN CVTEFNNMKI RKTCGWIIFV IQNCEIIIHS KGASTTLTEL VQSIDKNNEI
     QCAYVVFDAV SKIHFFMYAR ESSNSRDRMT YASSKQAILK KIEGVNVLTS VIESAQDVAD
     LK