ID   CADF2_PLAF7             Reviewed;         143 AA.
AC   Q8ID92;
DT   16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=Cofilin/actin-depolymerizing factor homolog 2 {ECO:0000250|UniProtKB:P86292};
GN   ORFNames=PF13_0326;
OS   Plasmodium falciparum (isolate 3D7).
OC   Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX   NCBI_TaxID=36329;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=3D7;
RX   PubMed=12368864; DOI=10.1038/nature01097;
RA   Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA   Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.D.,
RA   Eisen J.A., Rutherford K.M., Salzberg S.L., Craig A., Kyes S., Chan M.-S.,
RA   Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M.,
RA   Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M.A.,
RA   Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I.,
RA   Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J.,
RA   Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B.G.;
RT   "Genome sequence of the human malaria parasite Plasmodium falciparum.";
RL   Nature 419:498-511(2002).
RN   [2] {ECO:0000312|EMBL:CAD52734.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=3D7;
RX   PubMed=12368867; DOI=10.1038/nature01095;
RA   Hall N., Pain A., Berriman M., Churcher C.M., Harris B., Harris D.,
RA   Mungall K.L., Bowman S., Atkin R., Baker S., Barron A., Brooks K.,
RA   Buckee C.O., Burrows C., Cherevach I., Chillingworth C., Chillingworth T.,
RA   Christodoulou Z., Clark L., Clark R., Corton C., Cronin A., Davies R.M.,
RA   Davis P., Dear P., Dearden F., Doggett J., Feltwell T., Goble A.,
RA   Goodhead I., Gwilliam R., Hamlin N., Hance Z., Harper D., Hauser H.,
RA   Hornsby T., Holroyd S., Horrocks P., Humphray S., Jagels K., James K.D.,
RA   Johnson D., Kerhornou A., Knights A., Konfortov B., Kyes S., Larke N.,
RA   Lawson D., Lennard N., Line A., Maddison M., Mclean J., Mooney P.,
RA   Moule S., Murphy L., Oliver K., Ormond D., Price C., Quail M.A.,
RA   Rabbinowitsch E., Rajandream M.A., Rutter S., Rutherford K.M., Sanders M.,
RA   Simmonds M., Seeger K., Sharp S., Smith R., Squares R., Squares S.,
RA   Stevens K., Taylor K., Tivey A., Unwin L., Whitehead S., Woodward J.R.,
RA   Sulston J.E., Craig A., Newbold C., Barrell B.G.;
RT   "Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.";
RL   Nature 419:527-531(2002).
CC   -!- FUNCTION: Not involved in actin polymerisation, instead functions to
CC       stimulate nucleotide exchange on monomeric actin and influence turnover
CC       of the small amount of cytosolic actin microfilaments. Essential for
CC       erythrocytic schizogony (By similarity).
CC       {ECO:0000250|UniProtKB:P86292}.
CC   -!- SUBUNIT: Interacts with monomeric actin, does not bind to actin
CC       polymers. {ECO:0000250|UniProtKB:P86292}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q03048}.
CC       Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q03048}.
CC   -!- SIMILARITY: Belongs to the actin-binding proteins ADF family.
CC       {ECO:0000255}.
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DR   EMBL; AL844509; CAD52734.1; -; Genomic_DNA.
DR   RefSeq; XP_001350325.1; XM_001350289.1.
DR   AlphaFoldDB; Q8ID92; -.
DR   SMR; Q8ID92; -.
DR   STRING; 5833.PF13_0326; -.
DR   PRIDE; Q8ID92; -.
DR   EnsemblProtists; CAD52734; CAD52734; PF3D7_1361400.
DR   GeneID; 814286; -.
DR   KEGG; pfa:PF3D7_1361400; -.
DR   VEuPathDB; PlasmoDB:PF3D7_1361400; -.
DR   HOGENOM; CLU_094004_3_2_1; -.
DR   InParanoid; Q8ID92; -.
DR   OMA; ECKYAIY; -.
DR   PhylomeDB; Q8ID92; -.
DR   Proteomes; UP000001450; Chromosome 13.
DR   GO; GO:0015629; C:actin cytoskeleton; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0051015; F:actin filament binding; IBA:GO_Central.
DR   GO; GO:0003785; F:actin monomer binding; ISS:UniProtKB.
DR   GO; GO:0030036; P:actin cytoskeleton organization; ISS:UniProtKB.
DR   GO; GO:0030042; P:actin filament depolymerization; IBA:GO_Central.
DR   GO; GO:0008154; P:actin polymerization or depolymerization; ISS:GeneDB.
DR   GO; GO:0060327; P:cytoplasmic actin-based contraction involved in cell motility; ISS:UniProtKB.
DR   CDD; cd11286; ADF_cofilin_like; 1.
DR   Gene3D; 3.40.20.10; -; 1.
DR   InterPro; IPR002108; ADF-H.
DR   InterPro; IPR029006; ADF-H/Gelsolin-like_dom_sf.
DR   InterPro; IPR017904; ADF/Cofilin.
DR   PANTHER; PTHR11913; PTHR11913; 1.
DR   Pfam; PF00241; Cofilin_ADF; 1.
DR   SMART; SM00102; ADF; 1.
DR   PROSITE; PS51263; ADF_H; 1.
PE   3: Inferred from homology;
KW   Actin-binding; Cytoplasm; Cytoskeleton; Reference proteome.
FT   CHAIN           1..143
FT                   /note="Cofilin/actin-depolymerizing factor homolog 2"
FT                   /id="PRO_0000377708"
FT   DOMAIN          4..141
FT                   /note="ADF-H"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00599"
SQ   SEQUENCE   143 AA;  16998 MW;  E969FB02D105201C CRC64;
     MVSGVKVSDE CVYEFNKLKI KHIHKYIIYR IENYEEVIVD FLEQDNSLKS YKDIIIDIRN
     NLKTTECRYI IADMPIPTPE GVLRNRIYFI FWSPDLAKSK EKMLYASSKE YLVRKINGIF
     KSLEITCDLE DFEDELRTII LNT