ID   UREG_CORGL              Reviewed;         205 AA.
AC   Q79VJ1; Q9L417; Q9RHM1;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 102.
DE   RecName: Full=Urease accessory protein UreG {ECO:0000255|HAMAP-Rule:MF_01389};
GN   Name=ureG {ECO:0000255|HAMAP-Rule:MF_01389};
GN   OrderedLocusNames=Cgl0089, cg0118;
OS   Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 /
OS   JCM 1318 / LMG 3730 / NCIMB 10025).
OC   Bacteria; Actinobacteria; Corynebacteriales; Corynebacteriaceae;
OC   Corynebacterium.
OX   NCBI_TaxID=196627;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND INDUCTION.
RC   STRAIN=ATCC 13869 / DSMZ 1412 / NCIMB 9567;
RX   PubMed=11328647; DOI=10.3109/10425170009033989;
RA   Puskas L.G., Inui M., Yukawa H.;
RT   "Structure of the urease operon of Corynebacterium glutamicum.";
RL   DNA Seq. 11:383-394(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PROBABLE OPERON STRUCTURE.
RC   STRAIN=ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB
RC   10025;
RX   PubMed=10930756; DOI=10.1111/j.1574-6968.2000.tb09248.x;
RA   Nolden L., Beckers G., Moeckel B., Pfefferle W., Nampoothiri K.M.,
RA   Kraemer R., Burkovski A.;
RT   "Urease of Corynebacterium glutamicum: organization of corresponding genes
RT   and investigation of activity.";
RL   FEMS Microbiol. Lett. 189:305-310(2000).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB
RC   10025;
RX   PubMed=12743753; DOI=10.1007/s00253-003-1328-1;
RA   Ikeda M., Nakagawa S.;
RT   "The Corynebacterium glutamicum genome: features and impacts on
RT   biotechnological processes.";
RL   Appl. Microbiol. Biotechnol. 62:99-109(2003).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB
RC   10025;
RX   PubMed=12948626; DOI=10.1016/s0168-1656(03)00154-8;
RA   Kalinowski J., Bathe B., Bartels D., Bischoff N., Bott M., Burkovski A.,
RA   Dusch N., Eggeling L., Eikmanns B.J., Gaigalat L., Goesmann A.,
RA   Hartmann M., Huthmacher K., Kraemer R., Linke B., McHardy A.C., Meyer F.,
RA   Moeckel B., Pfefferle W., Puehler A., Rey D.A., Rueckert C., Rupp O.,
RA   Sahm H., Wendisch V.F., Wiegraebe I., Tauch A.;
RT   "The complete Corynebacterium glutamicum ATCC 13032 genome sequence and its
RT   impact on the production of L-aspartate-derived amino acids and vitamins.";
RL   J. Biotechnol. 104:5-25(2003).
CC   -!- FUNCTION: Facilitates the functional incorporation of the urease nickel
CC       metallocenter. This process requires GTP hydrolysis, probably
CC       effectuated by UreG. {ECO:0000255|HAMAP-Rule:MF_01389}.
CC   -!- SUBUNIT: Homodimer. UreD, UreF and UreG form a complex that acts as a
CC       GTP-hydrolysis-dependent molecular chaperone, activating the urease
CC       apoprotein by helping to assemble the nickel containing metallocenter
CC       of UreC. The UreE protein probably delivers the nickel.
CC       {ECO:0000255|HAMAP-Rule:MF_01389}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01389}.
CC   -!- INDUCTION: By urea and nitrogen starvation.
CC       {ECO:0000269|PubMed:11328647}.
CC   -!- SIMILARITY: Belongs to the SIMIBI class G3E GTPase family. UreG
CC       subfamily. {ECO:0000255|HAMAP-Rule:MF_01389}.
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DR   EMBL; AB029154; BAA88557.1; -; Genomic_DNA.
DR   EMBL; AJ251883; CAB81940.1; -; Genomic_DNA.
DR   EMBL; BA000036; BAB97482.1; -; Genomic_DNA.
DR   EMBL; BX927148; CAF18657.1; -; Genomic_DNA.
DR   RefSeq; NP_599341.1; NC_003450.3.
DR   RefSeq; WP_003857703.1; NC_006958.1.
DR   AlphaFoldDB; Q79VJ1; -.
DR   SMR; Q79VJ1; -.
DR   STRING; 196627.cg0118; -.
DR   GeneID; 58311482; -.
DR   KEGG; cgb:cg0118; -.
DR   KEGG; cgl:Cgl0089; -.
DR   PATRIC; fig|196627.13.peg.90; -.
DR   eggNOG; COG0378; Bacteria.
DR   HOGENOM; CLU_072144_1_0_11; -.
DR   OMA; TQEDAQH; -.
DR   Proteomes; UP000000582; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   GO; GO:0016151; F:nickel cation binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006807; P:nitrogen compound metabolic process; IEA:InterPro.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_01389; UreG; 1.
DR   InterPro; IPR003495; CobW/HypB/UreG_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR004400; UreG.
DR   PANTHER; PTHR31715; PTHR31715; 1.
DR   Pfam; PF02492; cobW; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00101; ureG; 1.
PE   2: Evidence at transcript level;
KW   Chaperone; Cytoplasm; GTP-binding; Nickel insertion; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..205
FT                   /note="Urease accessory protein UreG"
FT                   /id="PRO_0000347384"
FT   BINDING         10..17
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01389"
FT   CONFLICT        198
FT                   /note="M -> I (in Ref. 1; BAA88557)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   205 AA;  22418 MW;  202DA9A718F03D86 CRC64;
     MGPIRIGVGG PVGAGKTQLV ERITRALIDE VSMAAITNDI YTIEDAKILA ANGVLPEERI
     VGIETGGCPH TAIREDTSMN DAAIKDLVER FPDLELIFVE SGGDNLSATF SPELVDFSIY
     IIDVAQGEKI PRKAGQGMIK SDLFIINKTD LAPYVGANLD VMVEDAKAFR KNKPFCLTNL
     RTDDGLDKVL EWIRHEVMMQ DLQEA