ID   UREG_ECOLX              Reviewed;         205 AA.
AC   Q03287;
DT   01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1993, sequence version 1.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=Urease accessory protein UreG {ECO:0000255|HAMAP-Rule:MF_01389};
GN   Name=ureG {ECO:0000255|HAMAP-Rule:MF_01389};
OS   Escherichia coli.
OG   Plasmid.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=562;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND INDUCTION.
RC   STRAIN=1440 / UPEC;
RX   PubMed=8449894; DOI=10.1128/jb.175.6.1860-1864.1993;
RA   D'Orazio S.E., Collins C.M.;
RT   "Characterization of a plasmid-encoded urease gene cluster found in members
RT   of the family Enterobacteriaceae.";
RL   J. Bacteriol. 175:1860-1864(1993).
CC   -!- FUNCTION: Facilitates the functional incorporation of the urease nickel
CC       metallocenter. This process requires GTP hydrolysis, probably
CC       effectuated by UreG. {ECO:0000255|HAMAP-Rule:MF_01389}.
CC   -!- SUBUNIT: Homodimer. UreD, UreF and UreG form a complex that acts as a
CC       GTP-hydrolysis-dependent molecular chaperone, activating the urease
CC       apoprotein by helping to assemble the nickel containing metallocenter
CC       of UreC. The UreE protein probably delivers the nickel.
CC       {ECO:0000255|HAMAP-Rule:MF_01389}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01389}.
CC   -!- INDUCTION: The probable operon is induced by urea.
CC       {ECO:0000269|PubMed:8449894}.
CC   -!- SIMILARITY: Belongs to the SIMIBI class G3E GTPase family. UreG
CC       subfamily. {ECO:0000255|HAMAP-Rule:MF_01389}.
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DR   EMBL; L03308; AAA24749.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q03287; -.
DR   SMR; Q03287; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   GO; GO:0016151; F:nickel cation binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006807; P:nitrogen compound metabolic process; IEA:InterPro.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_01389; UreG; 1.
DR   InterPro; IPR003495; CobW/HypB/UreG_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR004400; UreG.
DR   PANTHER; PTHR31715; PTHR31715; 1.
DR   Pfam; PF02492; cobW; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00101; ureG; 1.
PE   2: Evidence at transcript level;
KW   Chaperone; Cytoplasm; GTP-binding; Nickel insertion; Nucleotide-binding;
KW   Plasmid.
FT   CHAIN           1..205
FT                   /note="Urease accessory protein UreG"
FT                   /id="PRO_0000067664"
FT   BINDING         14..21
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01389"
SQ   SEQUENCE   205 AA;  22240 MW;  FBA1096B4AD7D1FD CRC64;
     MQEYNQPLRI GVGGPVGSGK TALLEVLCKA MRDTYQIAVV TNDIYTQEDA KILTRAEALD
     ADRIIGVETG GCPHTAIRED ASMNLAAVEE LAIRHKNLDI VFVESGGDNL SATFSPELAD
     LTIYVIDVAE GEKIPRKGGP GITHSDLLVI NKIDLAPYVG ASLEVMEADT ARMRPVKPYV
     FTNLKKKVGL ETIIEFIIDK GMLGR