ID   UREG_HALMA              Reviewed;         207 AA.
AC   Q75ZQ3; Q5V6L5;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=Urease accessory protein UreG {ECO:0000255|HAMAP-Rule:MF_01389};
GN   Name=ureG {ECO:0000255|HAMAP-Rule:MF_01389}; OrderedLocusNames=pNG7126;
OS   Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM
OS   B-1809) (Halobacterium marismortui).
OG   Plasmid pNG700.
OC   Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC   Haloarculaceae; Haloarcula.
OX   NCBI_TaxID=272569;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809;
RX   PubMed=14981304; DOI=10.1271/bbb.68.397;
RA   Mizuki T., Kamekura M., DasSarma S., Fukushima T., Usami R., Yoshida Y.,
RA   Horikoshi K.;
RT   "Ureases of extreme halophiles of the genus Haloarcula with a unique
RT   structure of gene cluster.";
RL   Biosci. Biotechnol. Biochem. 68:397-406(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809; PLASMID=pNG700;
RX   PubMed=15520287; DOI=10.1101/gr.2700304;
RA   Baliga N.S., Bonneau R., Facciotti M.T., Pan M., Glusman G., Deutsch E.W.,
RA   Shannon P., Chiu Y., Weng R.S., Gan R.R., Hung P., Date S.V., Marcotte E.,
RA   Hood L., Ng W.V.;
RT   "Genome sequence of Haloarcula marismortui: a halophilic archaeon from the
RT   Dead Sea.";
RL   Genome Res. 14:2221-2234(2004).
CC   -!- FUNCTION: Facilitates the functional incorporation of the urease nickel
CC       metallocenter. This process requires GTP hydrolysis, probably
CC       effectuated by UreG. {ECO:0000255|HAMAP-Rule:MF_01389}.
CC   -!- SUBUNIT: Homodimer. UreD, UreF and UreG form a complex that acts as a
CC       GTP-hydrolysis-dependent molecular chaperone, activating the urease
CC       apoprotein by helping to assemble the nickel containing metallocenter
CC       of UreC. The UreE protein probably delivers the nickel.
CC       {ECO:0000255|HAMAP-Rule:MF_01389}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01389}.
CC   -!- SIMILARITY: Belongs to the SIMIBI class G3E GTPase family. UreG
CC       subfamily. {ECO:0000255|HAMAP-Rule:MF_01389}.
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DR   EMBL; AY596296; AAV44837.1; -; Genomic_DNA.
DR   EMBL; AB119092; BAC84960.1; -; Genomic_DNA.
DR   RefSeq; WP_004965716.1; NZ_CP039137.1.
DR   AlphaFoldDB; Q75ZQ3; -.
DR   SMR; Q75ZQ3; -.
DR   EnsemblBacteria; AAV44837; AAV44837; pNG7126.
DR   GeneID; 40151398; -.
DR   GeneID; 64825408; -.
DR   KEGG; hma:pNG7126; -.
DR   PATRIC; fig|272569.17.peg.569; -.
DR   HOGENOM; CLU_072144_1_0_2; -.
DR   OMA; VDLTIYV; -.
DR   Proteomes; UP000001169; Plasmid pNG700.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   GO; GO:0016151; F:nickel cation binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006807; P:nitrogen compound metabolic process; IEA:InterPro.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_01389; UreG; 1.
DR   InterPro; IPR003495; CobW/HypB/UreG_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR004400; UreG.
DR   PANTHER; PTHR31715; PTHR31715; 1.
DR   Pfam; PF02492; cobW; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00101; ureG; 1.
PE   3: Inferred from homology;
KW   Chaperone; Cytoplasm; GTP-binding; Nickel insertion; Nucleotide-binding;
KW   Plasmid; Reference proteome.
FT   CHAIN           1..207
FT                   /note="Urease accessory protein UreG"
FT                   /id="PRO_0000347459"
FT   BINDING         15..22
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01389"
SQ   SEQUENCE   207 AA;  21991 MW;  59AA46936ACC0752 CRC64;
     MSLTHRDVAT VGIGGPVGSG KTSLLTALVP ELRDQGLDVG VIANDILTQE DADVLRERFA
     GVVPEDLVAG VETGACPHTG IREDPSMNLQ QIDSFLADHP ELDLVLVESG GDNLAATFNP
     ELADYSLYVI SVAEGEDIPR KRGPGVVDCD LLVVNKTDLA PHVGADLDVM EHDANEVRDG
     PVVFTNCKDE TNIDTVLSHV RDGVLFA