UREG_STAA8
ID UREG_STAA8 Reviewed; 204 AA.
AC Q2G273;
DT 14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT 21-MAR-2006, sequence version 1.
DT 03-AUG-2022, entry version 93.
DE RecName: Full=Urease accessory protein UreG {ECO:0000255|HAMAP-Rule:MF_01389};
GN Name=ureG {ECO:0000255|HAMAP-Rule:MF_01389};
GN OrderedLocusNames=SAOUHSC_02564;
OS Staphylococcus aureus (strain NCTC 8325 / PS 47).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=93061;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCTC 8325 / PS 47;
RA Gillaspy A.F., Worrell V., Orvis J., Roe B.A., Dyer D.W., Iandolo J.J.;
RT "The Staphylococcus aureus NCTC 8325 genome.";
RL (In) Fischetti V., Novick R., Ferretti J., Portnoy D., Rood J. (eds.);
RL Gram positive pathogens, 2nd edition, pp.381-412, ASM Press, Washington
RL D.C. (2006).
CC -!- FUNCTION: Facilitates the functional incorporation of the urease nickel
CC metallocenter. This process requires GTP hydrolysis, probably
CC effectuated by UreG. {ECO:0000255|HAMAP-Rule:MF_01389}.
CC -!- SUBUNIT: Homodimer. UreD, UreF and UreG form a complex that acts as a
CC GTP-hydrolysis-dependent molecular chaperone, activating the urease
CC apoprotein by helping to assemble the nickel containing metallocenter
CC of UreC. The UreE protein probably delivers the nickel.
CC {ECO:0000255|HAMAP-Rule:MF_01389}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01389}.
CC -!- SIMILARITY: Belongs to the SIMIBI class G3E GTPase family. UreG
CC subfamily. {ECO:0000255|HAMAP-Rule:MF_01389}.
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DR EMBL; CP000253; ABD31576.1; -; Genomic_DNA.
DR RefSeq; WP_000002973.1; NZ_LS483365.1.
DR RefSeq; YP_501025.1; NC_007795.1.
DR AlphaFoldDB; Q2G273; -.
DR SMR; Q2G273; -.
DR STRING; 1280.SAXN108_2541; -.
DR EnsemblBacteria; ABD31576; ABD31576; SAOUHSC_02564.
DR GeneID; 3921561; -.
DR KEGG; sao:SAOUHSC_02564; -.
DR PATRIC; fig|93061.5.peg.2313; -.
DR eggNOG; COG0378; Bacteria.
DR HOGENOM; CLU_072144_1_0_9; -.
DR OMA; VDLTIYV; -.
DR PRO; PR:Q2G273; -.
DR Proteomes; UP000008816; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0016151; F:nickel cation binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006807; P:nitrogen compound metabolic process; IEA:InterPro.
DR Gene3D; 3.40.50.300; -; 1.
DR HAMAP; MF_01389; UreG; 1.
DR InterPro; IPR003495; CobW/HypB/UreG_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR004400; UreG.
DR PANTHER; PTHR31715; PTHR31715; 1.
DR Pfam; PF02492; cobW; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR00101; ureG; 1.
PE 3: Inferred from homology;
KW Chaperone; Cytoplasm; GTP-binding; Nickel insertion; Nucleotide-binding;
KW Reference proteome.
FT CHAIN 1..204
FT /note="Urease accessory protein UreG"
FT /id="PRO_1000145225"
FT BINDING 11..18
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01389"
SQ SEQUENCE 204 AA; 22345 MW; 491F129833F7F144 CRC64;
MANPIKIGIG GPVGAGKTQL IEKVVKRLSK EMSIGVITND IYTKEDEKIL VNSGVLPESR
IIGVETGGCP HTAIREDASM NFAAIDELLE RHDDIELIFI ESGGDNLAAT FSPELVDFSI
YIIDVAQGEK IPRKGGQGMI KSDFFVINKT DLAPYVGASL EQMAEDTKVF RGKRPFTFTN
LKTDEGLDEV IDWIERDTLL KGLS