ID   UREG_UREPA              Reviewed;         206 AA.
AC   Q56561;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 106.
DE   RecName: Full=Urease accessory protein UreG {ECO:0000255|HAMAP-Rule:MF_01389};
GN   Name=ureG {ECO:0000255|HAMAP-Rule:MF_01389}; OrderedLocusNames=UU429;
OS   Ureaplasma parvum serovar 3 (strain ATCC 700970).
OC   Bacteria; Tenericutes; Mollicutes; Mycoplasmataceae; Ureaplasma.
OX   NCBI_TaxID=273119;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 27813 / 7 / Serovar 1;
RX   PubMed=8550495; DOI=10.1128/jb.178.3.647-655.1996;
RA   Neyrolles O., Ferris S., Behbahani N., Montagnier L., Blanchard A.;
RT   "Organization of Ureaplasma urealyticum urease gene cluster and expression
RT   in a suppressor strain of Escherichia coli.";
RL   J. Bacteriol. 178:647-655(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700970;
RX   PubMed=11048724; DOI=10.1038/35037619;
RA   Glass J.I., Lefkowitz E.J., Glass J.S., Heiner C.R., Chen E.Y.,
RA   Cassell G.H.;
RT   "The complete sequence of the mucosal pathogen Ureaplasma urealyticum.";
RL   Nature 407:757-762(2000).
CC   -!- FUNCTION: Facilitates the functional incorporation of the urease nickel
CC       metallocenter. This process requires GTP hydrolysis, probably
CC       effectuated by UreG. {ECO:0000255|HAMAP-Rule:MF_01389}.
CC   -!- SUBUNIT: Homodimer. UreD, UreF and UreG form a complex that acts as a
CC       GTP-hydrolysis-dependent molecular chaperone, activating the urease
CC       apoprotein by helping to assemble the nickel containing metallocenter
CC       of UreC. The UreE protein probably delivers the nickel.
CC       {ECO:0000255|HAMAP-Rule:MF_01389}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01389}.
CC   -!- SIMILARITY: Belongs to the SIMIBI class G3E GTPase family. UreG
CC       subfamily. {ECO:0000255|HAMAP-Rule:MF_01389}.
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DR   EMBL; L40489; AAA89192.2; -; Genomic_DNA.
DR   EMBL; AF222894; AAF30841.1; -; Genomic_DNA.
DR   PIR; G82893; G82893.
DR   RefSeq; WP_006688745.1; NC_002162.1.
DR   AlphaFoldDB; Q56561; -.
DR   SMR; Q56561; -.
DR   STRING; 273119.UU429; -.
DR   EnsemblBacteria; AAF30841; AAF30841; UU429.
DR   GeneID; 29672328; -.
DR   KEGG; uur:UU429; -.
DR   eggNOG; COG0378; Bacteria.
DR   HOGENOM; CLU_072144_1_0_14; -.
DR   OMA; VDLTIYV; -.
DR   Proteomes; UP000000423; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   GO; GO:0016151; F:nickel cation binding; IEA:InterPro.
DR   GO; GO:0006807; P:nitrogen compound metabolic process; IEA:InterPro.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_01389; UreG; 1.
DR   InterPro; IPR003495; CobW/HypB/UreG_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR004400; UreG.
DR   PANTHER; PTHR31715; PTHR31715; 1.
DR   Pfam; PF02492; cobW; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00101; ureG; 1.
PE   3: Inferred from homology;
KW   Chaperone; Cytoplasm; GTP-binding; Nickel insertion; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..206
FT                   /note="Urease accessory protein UreG"
FT                   /id="PRO_0000067675"
FT   BINDING         11..18
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01389"
SQ   SEQUENCE   206 AA;  22509 MW;  51A64E8C4A9A52E7 CRC64;
     MKRPLIIGVG GPVGAGKTML IERLTRYLST KGYSMAAITN DIYTKEDARI LLNTSVLPAD
     RIAGVETGGC PHTAIREDAS MNFAAIEEMC DKHPDLQLLF LESGGDNLSA TFSPDLVDFS
     IYIIDVAQGE KIPRKGGQGM IKSDLFIINK VDLAPYVGAN VEVMKADTLK SRGNKDFFVT
     NLKTDEGLKS VADWIEKRLQ LALLEE