UREG_YERPE
ID UREG_YERPE Reviewed; 220 AA.
AC P69992; P52319; Q0WDL9; Q667Q3; Q9ZFR6;
DT 04-JAN-2005, integrated into UniProtKB/Swiss-Prot.
DT 04-JAN-2005, sequence version 1.
DT 03-AUG-2022, entry version 105.
DE RecName: Full=Urease accessory protein UreG {ECO:0000255|HAMAP-Rule:MF_01389};
GN Name=ureG {ECO:0000255|HAMAP-Rule:MF_01389};
GN OrderedLocusNames=YPO2670, y1242, YP_2471;
OS Yersinia pestis.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Yersiniaceae; Yersinia.
OX NCBI_TaxID=632;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND LACK OF ROLE IN VIRULENCE.
RC STRAIN=6/69M;
RX PubMed=11119503; DOI=10.1128/iai.69.1.170-176.2001;
RA Sebbane F., Devalckenaere A., Foulon J., Carniel E., Simonet M.;
RT "Silencing and reactivation of urease in Yersinia pestis is determined by
RT one G residue at a specific position in the ureD gene.";
RL Infect. Immun. 69:170-176(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CO-92 / Biovar Orientalis;
RX PubMed=11586360; DOI=10.1038/35097083;
RA Parkhill J., Wren B.W., Thomson N.R., Titball R.W., Holden M.T.G.,
RA Prentice M.B., Sebaihia M., James K.D., Churcher C.M., Mungall K.L.,
RA Baker S., Basham D., Bentley S.D., Brooks K., Cerdeno-Tarraga A.-M.,
RA Chillingworth T., Cronin A., Davies R.M., Davis P., Dougan G., Feltwell T.,
RA Hamlin N., Holroyd S., Jagels K., Karlyshev A.V., Leather S., Moule S.,
RA Oyston P.C.F., Quail M.A., Rutherford K.M., Simmonds M., Skelton J.,
RA Stevens K., Whitehead S., Barrell B.G.;
RT "Genome sequence of Yersinia pestis, the causative agent of plague.";
RL Nature 413:523-527(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KIM10+ / Biovar Mediaevalis;
RX PubMed=12142430; DOI=10.1128/jb.184.16.4601-4611.2002;
RA Deng W., Burland V., Plunkett G. III, Boutin A., Mayhew G.F., Liss P.,
RA Perna N.T., Rose D.J., Mau B., Zhou S., Schwartz D.C., Fetherston J.D.,
RA Lindler L.E., Brubaker R.R., Plano G.V., Straley S.C., McDonough K.A.,
RA Nilles M.L., Matson J.S., Blattner F.R., Perry R.D.;
RT "Genome sequence of Yersinia pestis KIM.";
RL J. Bacteriol. 184:4601-4611(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=91001 / Biovar Mediaevalis;
RX PubMed=15368893; DOI=10.1093/dnares/11.3.179;
RA Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D.,
RA Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L.,
RA Dai R., Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H.,
RA Wang J., Huang P., Yang R.;
RT "Complete genome sequence of Yersinia pestis strain 91001, an isolate
RT avirulent to humans.";
RL DNA Res. 11:179-197(2004).
CC -!- FUNCTION: Facilitates the functional incorporation of the urease nickel
CC metallocenter. This process requires GTP hydrolysis, probably
CC effectuated by UreG. {ECO:0000255|HAMAP-Rule:MF_01389}.
CC -!- SUBUNIT: Homodimer. UreD, UreF and UreG form a complex that acts as a
CC GTP-hydrolysis-dependent molecular chaperone, activating the urease
CC apoprotein by helping to assemble the nickel containing metallocenter
CC of UreC. The UreE protein probably delivers the nickel.
CC {ECO:0000255|HAMAP-Rule:MF_01389}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01389}.
CC -!- SIMILARITY: Belongs to the SIMIBI class G3E GTPase family. UreG
CC subfamily. {ECO:0000255|HAMAP-Rule:MF_01389}.
CC -!- CAUTION: The last gene of this probable operon, ureD, gives rise to a
CC truncated protein. Absence of ureD prevents expression of active
CC urease. Correction of the mutation does not effect virulence in mice in
CC any detectable fashion, suggesting urease is not important in the
CC virulence of Y.pestis (PubMed:11119503). {ECO:0000305|PubMed:11119503}.
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DR EMBL; AF095636; AAC78637.1; -; Genomic_DNA.
DR EMBL; AL590842; CAL21289.1; -; Genomic_DNA.
DR EMBL; AE009952; AAM84817.1; -; Genomic_DNA.
DR EMBL; AE017042; AAS62671.1; -; Genomic_DNA.
DR PIR; AF0325; AF0325.
DR RefSeq; WP_002212232.1; NZ_WHLN01000011.1.
DR RefSeq; YP_002347619.1; NC_003143.1.
DR AlphaFoldDB; P69992; -.
DR SMR; P69992; -.
DR IntAct; P69992; 1.
DR STRING; 214092.YPO2670; -.
DR PaxDb; P69992; -.
DR DNASU; 1146189; -.
DR EnsemblBacteria; AAM84817; AAM84817; y1242.
DR EnsemblBacteria; AAS62671; AAS62671; YP_2471.
DR GeneID; 66844637; -.
DR KEGG; ype:YPO2670; -.
DR KEGG; ypk:y1242; -.
DR KEGG; ypm:YP_2471; -.
DR PATRIC; fig|1028802.3.peg.1408; -.
DR eggNOG; COG0378; Bacteria.
DR HOGENOM; CLU_072144_1_0_6; -.
DR OMA; VDLTIYV; -.
DR Proteomes; UP000000815; Chromosome.
DR Proteomes; UP000001019; Chromosome.
DR Proteomes; UP000002490; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0016151; F:nickel cation binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006807; P:nitrogen compound metabolic process; IEA:InterPro.
DR Gene3D; 3.40.50.300; -; 1.
DR HAMAP; MF_01389; UreG; 1.
DR InterPro; IPR003495; CobW/HypB/UreG_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR004400; UreG.
DR PANTHER; PTHR31715; PTHR31715; 1.
DR Pfam; PF02492; cobW; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR00101; ureG; 1.
PE 3: Inferred from homology;
KW Chaperone; Cytoplasm; GTP-binding; Nickel insertion; Nucleotide-binding;
KW Reference proteome.
FT CHAIN 1..220
FT /note="Urease accessory protein UreG"
FT /id="PRO_0000067677"
FT BINDING 18..25
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01389"
SQ SEQUENCE 220 AA; 24007 MW; AC68DB5CE8DF629B CRC64;
MTDKSTARKK ITRIGIGGPV GSGKTAIIEV ITPILIKRGI KPLIITNDIV TTEDAKQVKR
TLKGILDEEK ILGVETGACP HTAVREDPSM NIAAVEEMEE RFPESDLIMI ESGGDNLTLT
FSPALADFYI YVIDVAEGEK IPRKNGPGLV QADILVINKI DLAPYVGASL DVMESDTKVV
RGNRPYILTN CKTGQGIEEL VDMIMRDFLF THVQPEGEQA
