ID   UREH_HELHP              Reviewed;         252 AA.
AC   Q7VJ35;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   02-SEP-2008, sequence version 2.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=Urease accessory protein UreH {ECO:0000255|HAMAP-Rule:MF_01384};
GN   Name=ureH {ECO:0000255|HAMAP-Rule:MF_01384}; OrderedLocusNames=HH_0413;
OS   Helicobacter hepaticus (strain ATCC 51449 / 3B1).
OC   Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC   Helicobacteraceae; Helicobacter.
OX   NCBI_TaxID=235279;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51449 / 3B1;
RX   PubMed=12810954; DOI=10.1073/pnas.1332093100;
RA   Suerbaum S., Josenhans C., Sterzenbach T., Drescher B., Brandt P., Bell M.,
RA   Droege M., Fartmann B., Fischer H.-P., Ge Z., Hoerster A., Holland R.,
RA   Klein K., Koenig J., Macko L., Mendz G.L., Nyakatura G., Schauer D.B.,
RA   Shen Z., Weber J., Frosch M., Fox J.G.;
RT   "The complete genome sequence of the carcinogenic bacterium Helicobacter
RT   hepaticus.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:7901-7906(2003).
CC   -!- FUNCTION: Required for maturation of urease via the functional
CC       incorporation of the urease nickel metallocenter. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
CC   -!- SUBUNIT: UreH, UreF and UreG form a complex that acts as a GTP-
CC       hydrolysis-dependent molecular chaperone, activating the urease
CC       apoprotein by helping to assemble the nickel containing metallocenter
CC       of UreC. The UreE protein probably delivers the nickel.
CC       {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SIMILARITY: Belongs to the UreD family. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAP77010.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AE017125; AAP77010.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_041308970.1; NC_004917.1.
DR   AlphaFoldDB; Q7VJ35; -.
DR   SMR; Q7VJ35; -.
DR   STRING; 235279.HH_0413; -.
DR   EnsemblBacteria; AAP77010; AAP77010; HH_0413.
DR   KEGG; hhe:HH_0413; -.
DR   eggNOG; COG0829; Bacteria.
DR   HOGENOM; CLU_056339_6_1_7; -.
DR   OMA; IPFENAH; -.
DR   OrthoDB; 1764668at2; -.
DR   Proteomes; UP000002495; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016151; F:nickel cation binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006807; P:nitrogen compound metabolic process; IEA:InterPro.
DR   HAMAP; MF_01384; UreD; 1.
DR   InterPro; IPR002669; UreD.
DR   PANTHER; PTHR33643; PTHR33643; 1.
DR   Pfam; PF01774; UreD; 1.
PE   3: Inferred from homology;
KW   Chaperone; Cytoplasm; Nickel insertion; Reference proteome.
FT   CHAIN           1..252
FT                   /note="Urease accessory protein UreH"
FT                   /id="PRO_0000346567"
SQ   SEQUENCE   252 AA;  28640 MW;  936FCAFA9F5E30DD CRC64;
     MSSFAQKSIL KLKTKRGLNG KNIIEEMFFT PPLKIISPLE DEDIAEIMLI SVSAGLLKDD
     CQDIQIHIGK ESKIRLISQS YEKIHDTQDG YASKHTQITI EENAFLDYAP LPILPFKDSS
     FKNTTDIYLS KNARLHYSEI ICAGRVAMGE IFDFSELSSR LRIYKENHLV FFENMNLKPA
     QMAMQNICLF DKYTHALSMV IFDDLIEVQA LEQKIKNSSL NVGISTNNGG IIIKALDNQS
     ERLLQFKKDL AL