ID   UREH_HELP2              Reviewed;         265 AA.
AC   B6JPH0;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   16-DEC-2008, sequence version 1.
DT   25-MAY-2022, entry version 52.
DE   RecName: Full=Urease accessory protein UreH {ECO:0000255|HAMAP-Rule:MF_01384};
GN   Name=ureH {ECO:0000255|HAMAP-Rule:MF_01384}; OrderedLocusNames=HPP12_0071;
OS   Helicobacter pylori (strain P12).
OC   Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC   Helicobacteraceae; Helicobacter.
OX   NCBI_TaxID=570508;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=P12;
RA   Fischer W., Windhager L., Karnholz A., Zeiller M., Zimmer R., Haas R.;
RT   "The complete genome sequence of Helicobacter pylori strain P12.";
RL   Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for maturation of urease via the functional
CC       incorporation of the urease nickel metallocenter. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
CC   -!- SUBUNIT: UreH, UreF and UreG form a complex that acts as a GTP-
CC       hydrolysis-dependent molecular chaperone, activating the urease
CC       apoprotein by helping to assemble the nickel containing metallocenter
CC       of UreC. The UreE protein probably delivers the nickel.
CC       {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SIMILARITY: Belongs to the UreD family. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
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DR   EMBL; CP001217; ACJ07231.1; -; Genomic_DNA.
DR   RefSeq; WP_001099412.1; NC_011498.1.
DR   AlphaFoldDB; B6JPH0; -.
DR   SMR; B6JPH0; -.
DR   EnsemblBacteria; ACJ07231; ACJ07231; HPP12_0071.
DR   KEGG; hpp:HPP12_0071; -.
DR   HOGENOM; CLU_056339_6_1_7; -.
DR   OMA; IPFENAH; -.
DR   OrthoDB; 1764668at2; -.
DR   Proteomes; UP000008198; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016151; F:nickel cation binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006807; P:nitrogen compound metabolic process; IEA:InterPro.
DR   HAMAP; MF_01384; UreD; 1.
DR   InterPro; IPR002669; UreD.
DR   PANTHER; PTHR33643; PTHR33643; 1.
DR   Pfam; PF01774; UreD; 1.
PE   3: Inferred from homology;
KW   Chaperone; Cytoplasm; Nickel insertion.
FT   CHAIN           1..265
FT                   /note="Urease accessory protein UreH"
FT                   /id="PRO_1000145092"
SQ   SEQUENCE   265 AA;  29728 MW;  26043BD5F8C8ED74 CRC64;
     MNTYAQESKL RLKTKIGADG RCVIEDNFFT PPFKLMAPFY PKDDLAEIML LAVSPGLMKG
     DAQDMQLSIG QNCKLRITSQ SFEKIHNTED GFASRDMHIV VGENAFLDFA PFPLIPFENA
     HFKGNTTISL RSSSQLLYSE IIVAGRVARN ELFKFNRLHT KISILQDEKP IYYDNTILDP
     KTTDMNNMCM FDGYTHYLNL VLVNCPIELS GVRGLIEESE GVDGAVSEIA SSHLCVKALA
     KGSEPLLHLR EKIARFTTQT ITQKV