ID   UREH_HELPH              Reviewed;         265 AA.
AC   Q1CV87;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   11-JUL-2006, sequence version 1.
DT   25-MAY-2022, entry version 68.
DE   RecName: Full=Urease accessory protein UreH {ECO:0000255|HAMAP-Rule:MF_01384};
GN   Name=ureH {ECO:0000255|HAMAP-Rule:MF_01384}; OrderedLocusNames=HPAG1_0068;
OS   Helicobacter pylori (strain HPAG1).
OC   Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC   Helicobacteraceae; Helicobacter.
OX   NCBI_TaxID=357544;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HPAG1;
RX   PubMed=16788065; DOI=10.1073/pnas.0603784103;
RA   Oh J.D., Kling-Baeckhed H., Giannakis M., Xu J., Fulton R.S., Fulton L.A.,
RA   Cordum H.S., Wang C., Elliott G., Edwards J., Mardis E.R., Engstrand L.G.,
RA   Gordon J.I.;
RT   "The complete genome sequence of a chronic atrophic gastritis Helicobacter
RT   pylori strain: evolution during disease progression.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:9999-10004(2006).
CC   -!- FUNCTION: Required for maturation of urease via the functional
CC       incorporation of the urease nickel metallocenter. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
CC   -!- SUBUNIT: UreH, UreF and UreG form a complex that acts as a GTP-
CC       hydrolysis-dependent molecular chaperone, activating the urease
CC       apoprotein by helping to assemble the nickel containing metallocenter
CC       of UreC. The UreE protein probably delivers the nickel.
CC       {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SIMILARITY: Belongs to the UreD family. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
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DR   EMBL; CP000241; ABF84135.1; -; Genomic_DNA.
DR   RefSeq; WP_001099421.1; NC_008086.1.
DR   AlphaFoldDB; Q1CV87; -.
DR   SMR; Q1CV87; -.
DR   EnsemblBacteria; ABF84135; ABF84135; HPAG1_0068.
DR   KEGG; hpa:HPAG1_0068; -.
DR   HOGENOM; CLU_056339_6_1_7; -.
DR   OMA; IPFENAH; -.
DR   OrthoDB; 1764668at2; -.
DR   Proteomes; UP000008835; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016151; F:nickel cation binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006807; P:nitrogen compound metabolic process; IEA:InterPro.
DR   HAMAP; MF_01384; UreD; 1.
DR   InterPro; IPR002669; UreD.
DR   PANTHER; PTHR33643; PTHR33643; 1.
DR   Pfam; PF01774; UreD; 1.
PE   3: Inferred from homology;
KW   Chaperone; Cytoplasm; Nickel insertion.
FT   CHAIN           1..265
FT                   /note="Urease accessory protein UreH"
FT                   /id="PRO_1000145094"
SQ   SEQUENCE   265 AA;  29617 MW;  481A9A9BD3241DC3 CRC64;
     MNTYAQESKL RLKTKIGADG RCVIEDNFFT PPFKLMAPFY PKDDLAEIML LAVSPGLMKG
     DAQDVQLNIG PNCKLRITSQ SFEKIHNTED GFASRDMHIV VGENAFLDFA PFPLIPFENA
     HFKGNTTISL RSSSQLLYSE IIVAGRVACN ELFQFNRLHT KISILQDEKP IYYDNTILDP
     KTTDMMNMCM FDGYTHYLNL VLVNCPIELS GVRGLIEESE GVDGAVSEIA SSHLCVKALA
     KGSEPLLHLR EKIARLITQT ITPKI