ID   UREH_HELPJ              Reviewed;         265 AA.
AC   Q9ZMZ8;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   25-MAY-2022, entry version 92.
DE   RecName: Full=Urease accessory protein UreH {ECO:0000255|HAMAP-Rule:MF_01384};
GN   Name=ureH {ECO:0000255|HAMAP-Rule:MF_01384}; OrderedLocusNames=jhp_0062;
OS   Helicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99).
OC   Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC   Helicobacteraceae; Helicobacter.
OX   NCBI_TaxID=85963;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=J99 / ATCC 700824;
RX   PubMed=9923682; DOI=10.1038/16495;
RA   Alm R.A., Ling L.-S.L., Moir D.T., King B.L., Brown E.D., Doig P.C.,
RA   Smith D.R., Noonan B., Guild B.C., deJonge B.L., Carmel G., Tummino P.J.,
RA   Caruso A., Uria-Nickelsen M., Mills D.M., Ives C., Gibson R., Merberg D.,
RA   Mills S.D., Jiang Q., Taylor D.E., Vovis G.F., Trust T.J.;
RT   "Genomic sequence comparison of two unrelated isolates of the human gastric
RT   pathogen Helicobacter pylori.";
RL   Nature 397:176-180(1999).
CC   -!- FUNCTION: Required for maturation of urease via the functional
CC       incorporation of the urease nickel metallocenter. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
CC   -!- SUBUNIT: UreH, UreF and UreG form a complex that acts as a GTP-
CC       hydrolysis-dependent molecular chaperone, activating the urease
CC       apoprotein by helping to assemble the nickel containing metallocenter
CC       of UreC. The UreE protein probably delivers the nickel.
CC       {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SIMILARITY: Belongs to the UreD family. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
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DR   EMBL; AE001439; AAD05646.1; -; Genomic_DNA.
DR   PIR; B71979; B71979.
DR   RefSeq; WP_001099400.1; NZ_CP011330.1.
DR   AlphaFoldDB; Q9ZMZ8; -.
DR   SMR; Q9ZMZ8; -.
DR   STRING; 85963.jhp_0062; -.
DR   EnsemblBacteria; AAD05646; AAD05646; jhp_0062.
DR   KEGG; hpj:jhp_0062; -.
DR   PATRIC; fig|85963.30.peg.972; -.
DR   eggNOG; COG0829; Bacteria.
DR   OMA; IPFENAH; -.
DR   Proteomes; UP000000804; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016151; F:nickel cation binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006807; P:nitrogen compound metabolic process; IEA:InterPro.
DR   HAMAP; MF_01384; UreD; 1.
DR   InterPro; IPR002669; UreD.
DR   PANTHER; PTHR33643; PTHR33643; 1.
DR   Pfam; PF01774; UreD; 1.
PE   3: Inferred from homology;
KW   Chaperone; Cytoplasm; Nickel insertion.
FT   CHAIN           1..265
FT                   /note="Urease accessory protein UreH"
FT                   /id="PRO_0000067625"
SQ   SEQUENCE   265 AA;  29732 MW;  E6786536A3328B7D CRC64;
     MNTYAQESKL RLKTKIGADG RCVIEDNFFT PPFKLMAPFY PKDDLAEIML LAVSPGLMKG
     DAQDMQLNIG PNCKLRITSQ SFEKIHNTED GFASRDMHIV VGENAFLDFA PFPLIPFENA
     HFKGNTTISL RSSSQLLYSE IIVAGRVARN ELFKFNRLHT KISILQDEKP IYYDNTILDP
     KTTNMNNMCM FDGYTHYLNL VLVNCPIELS GARELIEESE GVDGAVSKIA SSHLCLKALA
     KGSEPLLHLR EKIARLVTQT TTQKV