ID   URER_ECOLX              Reviewed;         296 AA.
AC   P32326;
DT   01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1993, sequence version 1.
DT   25-MAY-2022, entry version 85.
DE   RecName: Full=Urease operon transcriptional activator;
GN   Name=ureR;
OS   Escherichia coli.
OG   Plasmid.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=562;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8501050; DOI=10.1128/jb.175.11.3459-3467.1993;
RA   D'Orazio S.E.F., Collins C.M.;
RT   "The plasmid-encoded urease gene cluster of the family Enterobacteriaceae
RT   is positively regulated by UreR, a member of the AraC family of
RT   transcriptional activators.";
RL   J. Bacteriol. 175:3459-3467(1993).
CC   -!- FUNCTION: Positive regulator of the expression of the urease operon.
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DR   EMBL; L12007; AAA24750.1; -; Genomic_DNA.
DR   PIR; A40593; A40593.
DR   RefSeq; WP_004257901.1; NZ_WJGH01000013.1.
DR   AlphaFoldDB; P32326; -.
DR   SMR; P32326; -.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR018060; HTH_AraC.
DR   InterPro; IPR018062; HTH_AraC-typ_CS.
DR   InterPro; IPR020449; Tscrpt_reg_HTH_AraC-type.
DR   Pfam; PF12833; HTH_18; 1.
DR   PRINTS; PR00032; HTHARAC.
DR   SMART; SM00342; HTH_ARAC; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00041; HTH_ARAC_FAMILY_1; 1.
DR   PROSITE; PS01124; HTH_ARAC_FAMILY_2; 1.
PE   4: Predicted;
KW   Activator; DNA-binding; Plasmid; Transcription; Transcription regulation.
FT   CHAIN           1..296
FT                   /note="Urease operon transcriptional activator"
FT                   /id="PRO_0000194590"
FT   DOMAIN          171..268
FT                   /note="HTH araC/xylS-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
FT   DNA_BIND        188..209
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
FT   DNA_BIND        235..258
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
SQ   SEQUENCE   296 AA;  34032 MW;  A98FF3D3EEFC1C16 CRC64;
     MEYKFFLSES QMVLKAFYIE SAMIAMLTGA KGNIVINGQS IEIESDVTLI IPKYSQVSCN
     IVCNTVKQPL ELHTLSMSAE ELQAVFLLLK TLMKSGAPLT SHQPIYHISP PETVRDNFSL
     LKQCLPLKKQ SASQEALLMK QSLYFILMAI YQEGIDILNL FRFNYDEPKN QAITHLITQE
     PQKKWHLDDV AKALFTTPST LRRHLNREGV SFRQLLLDVR MGMALNYLTF SNYSVFQISH
     RCGFGSNAYF CDVFKRKYNM TPSQFRLQSR QSNDPNFITN LSLRSNPIEF DKEIDE