ID   URGCP_BOVIN             Reviewed;         922 AA.
AC   A0JN92; Q58DE0;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   20-MAY-2008, sequence version 2.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=Up-regulator of cell proliferation;
DE   AltName: Full=HBV X protein up-regulated gene 4 protein homolog;
DE   AltName: Full=HBxAg up-regulated gene 4 protein homolog;
GN   Name=URGCP; Synonyms=URG4;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1] {ECO:0000312|EMBL:AAX46504.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA   Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA   Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT   "Characterization of 954 bovine full-CDS cDNA sequences.";
RL   BMC Genomics 6:166-166(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hereford;
RX   PubMed=19390049; DOI=10.1126/science.1169588;
RG   The bovine genome sequencing and analysis consortium;
RT   "The genome sequence of taurine cattle: a window to ruminant biology and
RT   evolution.";
RL   Science 324:522-528(2009).
RN   [3] {ECO:0000305, ECO:0000312|EMBL:AAI26572.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-915.
RC   STRAIN=Hereford {ECO:0000312|EMBL:AAI26572.1};
RC   TISSUE=Fetal spinal cord {ECO:0000312|EMBL:AAI26572.1};
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May be involved in cell cycle progression through the
CC       regulation of cyclin D1 expression. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q8TCY9}. Nucleus
CC       {ECO:0000250|UniProtKB:Q8TCY9}. Note=In epithelial cells localized
CC       predominantly in the cytoplasm and occasionally in nuclei.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TRAFAC class dynamin-like GTPase
CC       superfamily. Very large inducible GTPase (VLIG) family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAI26572.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};
CC       Sequence=AAX46504.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; BT021657; AAX46504.1; ALT_FRAME; mRNA.
DR   EMBL; AAFC03035144; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC126571; AAI26572.1; ALT_SEQ; mRNA.
DR   RefSeq; NP_001015513.2; NM_001015513.2.
DR   AlphaFoldDB; A0JN92; -.
DR   STRING; 9913.ENSBTAP00000040111; -.
DR   PaxDb; A0JN92; -.
DR   PRIDE; A0JN92; -.
DR   Ensembl; ENSBTAT00000040335; ENSBTAP00000040111; ENSBTAG00000009453.
DR   GeneID; 504226; -.
DR   KEGG; bta:504226; -.
DR   CTD; 55665; -.
DR   VEuPathDB; HostDB:ENSBTAG00000009453; -.
DR   eggNOG; ENOG502QU4G; Eukaryota.
DR   GeneTree; ENSGT00940000154390; -.
DR   HOGENOM; CLU_002276_0_0_1; -.
DR   InParanoid; A0JN92; -.
DR   OMA; QENTDGT; -.
DR   OrthoDB; 31942at2759; -.
DR   TreeFam; TF335271; -.
DR   Proteomes; UP000009136; Chromosome 22.
DR   Bgee; ENSBTAG00000009453; Expressed in vas deferens and 106 other tissues.
DR   ExpressionAtlas; A0JN92; baseline and differential.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR030383; G_VLIG_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS51717; G_VLIG; 1.
PE   2: Evidence at transcript level;
KW   Cell cycle; Cytoplasm; GTP-binding; Nucleotide-binding; Nucleus;
KW   Phosphoprotein; Reference proteome.
FT   CHAIN           1..922
FT                   /note="Up-regulator of cell proliferation"
FT                   /id="PRO_0000337147"
FT   DOMAIN          680..920
FT                   /note="VLIG-type G"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01054"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         3
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8TCY9"
FT   CONFLICT        461
FT                   /note="Q -> T (in Ref. 1; AAX46504)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   922 AA;  104872 MW;  C71C8AE4DA14E787 CRC64;
     MASSGHSDLG EVTSEIKASE RRTAVAIADL EWREMEGDDC EFHYGEGPNE AQDNDFPIEE
     RSRLQEMLFL LGLETYQTQK LSLQDALQIS SDSMKNWAPQ TPKDLPWNFL RKLQALNAEA
     RNTTMVLDLP LDTRPVEKES QMEEEIIYWD TAEDISADIY SFSELPTPDT PVNPLDLLCA
     LLLSSDSFLQ QEIVSKMSLC QFALPLILPD PENHYHTFLL WAMRGTVRTW GSQPPRVMGS
     FREDSMVLSR APAFAFVRME VSSNSKSQLL NDVLSPGHRQ QDCFWHRDLN LGTNPREIAD
     GLVEISWFLP SGREDLDIFP EPMAFLNLRG DIGSHWLQFK LLTEISSAIF ILTDNISKKE
     YKLLSSMKGS ATKYYFILSP YRGKRNTNLR FLNRLIPVLK MDHSHVLVKV SSTDSVGFVR
     RVRAIITHVT RSPCRRVSVE DMANAARKLG LKVDEDCEEC QRAKDRMEQI TRKIKDLDAY
     RRDELRLQGE TWRKVAQVEK ELCQIQWASD PPEKYRAELR HRLLELRMQQ NDHDPSWGVQ
     EFISGISSPS LGEKQYFLKW MEWGLARVAQ PRPRPSPEMI FTLRPKHCGA VDFSEPFWPE
     PLGVEHFLRE MGQFYEAESC LVEAGKLPAG QRRFAHFPGL ALELLLKGLP LELIDGNTLS
     PALRWVTGLL KELHVRLERR SRLVVLSALG VPGTGKSTLL NTMFGLRFVT GRGRGPRGAF
     MQLIKVAESF SQDLGCDHIL VIDSGGLIAG VRTEAGERFE REASLATLIM GLSNVTVVSL
     AETRNIPPAI LHAFLRLEKT GHMPNYQFVH QNLHDVSALG SKPRDRRQLL DQPSDVGRAT
     VQMEKQGDGI QTLADLAFWD PEKQHIWHIP GLWHGVPPMA AVNLAYSEAI FELKRCLLEN
     IRNGLSNQNK NIQQLIELVR RL