URGCP_HUMAN
ID URGCP_HUMAN Reviewed; 931 AA.
AC Q8TCY9; E9PFF6; Q658M4; Q68DH6; Q6MZZ5; Q8WV98; Q9NWR7; Q9P221;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 20-MAY-2008, sequence version 2.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=Up-regulator of cell proliferation;
DE AltName: Full=HBV X protein up-regulated gene 4 protein;
DE AltName: Full=HBxAg up-regulated gene 4 protein;
GN Name=URGCP; Synonyms=KIAA1507 {ECO:0000312|EMBL:BAA96031.1}, URG4;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1] {ECO:0000305, ECO:0000312|EMBL:AAL83710.1}
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, SUBCELLULAR LOCATION,
RP TISSUE SPECIFICITY, AND INDUCTION BY HBXAG.
RX PubMed=12082552; DOI=10.1038/sj.neo.7900241;
RA Tufan N.L.S., Lian Z., Liu J., Pan J., Arbuthnot P., Kew M., Clayton M.M.,
RA Zhu M., Feitelson M.A.;
RT "Hepatitis Bx antigen stimulates expression of a novel cellular gene, URG4,
RT that promotes hepatocellular growth and survival.";
RL Neoplasia 4:355-368(2002).
RN [2] {ECO:0000305, ECO:0000312|EMBL:BAA96031.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RC TISSUE=Brain {ECO:0000269|PubMed:10819331};
RX PubMed=10819331; DOI=10.1093/dnares/7.2.143;
RA Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. XVII. The
RT complete sequences of 100 new cDNA clones from brain which code for large
RT proteins in vitro.";
RL DNA Res. 7:143-150(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 470-931 (ISOFORMS 1/2), AND VARIANT LEU-779.
RC TISSUE=Endometrial adenocarcinoma, Endometrium, and Stomach;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [4] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12853948; DOI=10.1038/nature01782;
RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA Wilson R.K.;
RT "The DNA sequence of human chromosome 7.";
RL Nature 424:157-164(2003).
RN [5] {ECO:0000305, ECO:0000312|EMBL:AAH18426.2}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND VARIANT LEU-779.
RC TISSUE=Glioblastoma {ECO:0000312|EMBL:AAH18426.2};
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6] {ECO:0000305, ECO:0000312|EMBL:BAA91312.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 601-931.
RC TISSUE=Signet-ring cell carcinoma {ECO:0000269|PubMed:14702039};
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [7] {ECO:0000305}
RP FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND INDUCTION.
RX PubMed=17217616; DOI=10.1593/neo.06592;
RA Song J., Xie H., Lian Z., Yang G., Du R., Du Y., Zou X., Jin H., Gao J.,
RA Liu J., Fan D.;
RT "Enhanced cell survival of gastric cancer cells by a novel gene URG4.";
RL Neoplasia 8:995-1002(2006).
RN [8]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-3, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma, and Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
CC -!- FUNCTION: May be involved in cell cycle progression through the
CC regulation of cyclin D1 expression. May participate in the development
CC of hepatocellular carcinoma (HCC) by promoting hepatocellular growth
CC and survival. May play an important role in development of gastric
CC cancer. {ECO:0000269|PubMed:12082552, ECO:0000269|PubMed:17217616}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12082552,
CC ECO:0000269|PubMed:17217616}. Nucleus {ECO:0000269|PubMed:12082552,
CC ECO:0000269|PubMed:17217616}. Note=In epithelial cells localized
CC predominantly in the cytoplasm and occasionally in nuclei.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1;
CC IsoId=Q8TCY9-1; Sequence=Displayed;
CC Name=2 {ECO:0000269|PubMed:12082552, ECO:0000269|PubMed:15489334};
CC IsoId=Q8TCY9-2; Sequence=VSP_052799;
CC Name=3;
CC IsoId=Q8TCY9-3; Sequence=VSP_033942;
CC Name=4;
CC IsoId=Q8TCY9-4; Sequence=VSP_047068;
CC -!- TISSUE SPECIFICITY: Strongly expressed in hepatitis B virus-infected
CC liver and in HCC cells. Also highly expressed in well-differentiated
CC gastric cancer tissues and various gastric cancer cell lines.
CC {ECO:0000269|PubMed:12082552, ECO:0000269|PubMed:17217616}.
CC -!- INDUCTION: By HBxAg. Up-regulated in gastric cancer tissues and also in
CC gastric cancer cell lines (at protein level).
CC {ECO:0000269|PubMed:12082552, ECO:0000269|PubMed:17217616}.
CC -!- SIMILARITY: Belongs to the TRAFAC class dynamin-like GTPase
CC superfamily. Very large inducible GTPase (VLIG) family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA91312.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BAA96031.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=CAE45880.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=CAH18244.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=CAH18244.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AY078404; AAL83710.1; -; mRNA.
DR EMBL; AB040940; BAA96031.1; ALT_INIT; mRNA.
DR EMBL; AL833744; CAH56246.1; -; mRNA.
DR EMBL; BX640797; CAE45880.1; ALT_INIT; mRNA.
DR EMBL; CR749398; CAH18244.1; ALT_SEQ; mRNA.
DR EMBL; AC004985; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; BC018426; AAH18426.2; -; mRNA.
DR EMBL; AK000661; BAA91312.1; ALT_INIT; mRNA.
DR CCDS; CCDS43572.1; -. [Q8TCY9-4]
DR CCDS; CCDS47577.1; -. [Q8TCY9-2]
DR CCDS; CCDS47578.1; -. [Q8TCY9-1]
DR RefSeq; NP_001071131.1; NM_001077663.2. [Q8TCY9-1]
DR RefSeq; NP_001071132.1; NM_001077664.2. [Q8TCY9-4]
DR RefSeq; NP_001277004.1; NM_001290075.1. [Q8TCY9-4]
DR RefSeq; NP_001277005.1; NM_001290076.1. [Q8TCY9-4]
DR RefSeq; NP_060390.3; NM_017920.4. [Q8TCY9-2]
DR AlphaFoldDB; Q8TCY9; -.
DR BioGRID; 120797; 30.
DR IntAct; Q8TCY9; 4.
DR MINT; Q8TCY9; -.
DR STRING; 9606.ENSP00000396918; -.
DR iPTMnet; Q8TCY9; -.
DR PhosphoSitePlus; Q8TCY9; -.
DR BioMuta; URGCP; -.
DR DMDM; 189038114; -.
DR EPD; Q8TCY9; -.
DR jPOST; Q8TCY9; -.
DR MassIVE; Q8TCY9; -.
DR MaxQB; Q8TCY9; -.
DR PaxDb; Q8TCY9; -.
DR PeptideAtlas; Q8TCY9; -.
DR PRIDE; Q8TCY9; -.
DR ProteomicsDB; 20091; -.
DR ProteomicsDB; 74196; -. [Q8TCY9-1]
DR ProteomicsDB; 74197; -. [Q8TCY9-2]
DR ProteomicsDB; 74198; -. [Q8TCY9-3]
DR Antibodypedia; 7083; 170 antibodies from 24 providers.
DR DNASU; 55665; -.
DR Ensembl; ENST00000336086.10; ENSP00000336872.6; ENSG00000106608.17. [Q8TCY9-4]
DR Ensembl; ENST00000402306.7; ENSP00000384955.3; ENSG00000106608.17. [Q8TCY9-2]
DR Ensembl; ENST00000443736.5; ENSP00000392136.1; ENSG00000106608.17. [Q8TCY9-4]
DR Ensembl; ENST00000453200.6; ENSP00000396918.1; ENSG00000106608.17. [Q8TCY9-1]
DR GeneID; 55665; -.
DR KEGG; hsa:55665; -.
DR MANE-Select; ENST00000453200.6; ENSP00000396918.1; NM_001077663.3; NP_001071131.1.
DR UCSC; uc003tiu.4; human. [Q8TCY9-1]
DR CTD; 55665; -.
DR DisGeNET; 55665; -.
DR GeneCards; URGCP; -.
DR HGNC; HGNC:30890; URGCP.
DR HPA; ENSG00000106608; Low tissue specificity.
DR MIM; 610337; gene.
DR neXtProt; NX_Q8TCY9; -.
DR OpenTargets; ENSG00000106608; -.
DR PharmGKB; PA165618458; -.
DR VEuPathDB; HostDB:ENSG00000106608; -.
DR eggNOG; ENOG502QU4G; Eukaryota.
DR GeneTree; ENSGT00940000154390; -.
DR HOGENOM; CLU_002276_0_0_1; -.
DR InParanoid; Q8TCY9; -.
DR OMA; QENTDGT; -.
DR OrthoDB; 31942at2759; -.
DR PhylomeDB; Q8TCY9; -.
DR TreeFam; TF335271; -.
DR PathwayCommons; Q8TCY9; -.
DR SignaLink; Q8TCY9; -.
DR BioGRID-ORCS; 55665; 28 hits in 1069 CRISPR screens.
DR ChiTaRS; URGCP; human.
DR GeneWiki; URG4; -.
DR GenomeRNAi; 55665; -.
DR Pharos; Q8TCY9; Tbio.
DR PRO; PR:Q8TCY9; -.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; Q8TCY9; protein.
DR Bgee; ENSG00000106608; Expressed in right adrenal gland cortex and 187 other tissues.
DR ExpressionAtlas; Q8TCY9; baseline and differential.
DR Genevisible; Q8TCY9; HS.
DR GO; GO:0005829; C:cytosol; IDA:HPA.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR030383; G_VLIG_dom.
DR InterPro; IPR006073; GTP-bd.
DR InterPro; IPR027417; P-loop_NTPase.
DR PRINTS; PR00326; GTP1OBG.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS51717; G_VLIG; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cell cycle; Cytoplasm; GTP-binding;
KW Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome.
FT CHAIN 1..931
FT /note="Up-regulator of cell proliferation"
FT /id="PRO_0000337148"
FT DOMAIN 689..929
FT /note="VLIG-type G"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01054"
FT MOD_RES 3
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT VAR_SEQ 1..75
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:10819331"
FT /id="VSP_033942"
FT VAR_SEQ 1..43
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000305"
FT /id="VSP_047068"
FT VAR_SEQ 6..14
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:12082552,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_052799"
FT VARIANT 697
FT /note="T -> A (in dbSNP:rs2232106)"
FT /id="VAR_051479"
FT VARIANT 756
FT /note="L -> F (in dbSNP:rs2232107)"
FT /id="VAR_051480"
FT VARIANT 779
FT /note="M -> L (in dbSNP:rs2232108)"
FT /evidence="ECO:0000269|PubMed:15489334,
FT ECO:0000269|PubMed:17974005"
FT /id="VAR_043668"
FT CONFLICT 6
FT /note="Missing (in Ref. 3; CAH18244)"
FT /evidence="ECO:0000305"
FT CONFLICT 290
FT /note="W -> C (in Ref. 3; CAE45880)"
FT /evidence="ECO:0000305"
FT CONFLICT 390
FT /note="Y -> H (in Ref. 3; CAH18244)"
FT /evidence="ECO:0000305"
FT CONFLICT 432
FT /note="R -> Q (in Ref. 3; CAH18244)"
FT /evidence="ECO:0000305"
FT CONFLICT 516
FT /note="W -> R (in Ref. 3; CAE45880)"
FT /evidence="ECO:0000305"
FT CONFLICT 544
FT /note="P -> S (in Ref. 1; AAL83710)"
FT /evidence="ECO:0000305"
FT CONFLICT 601
FT /note="D -> G (in Ref. 6; BAA91312)"
FT /evidence="ECO:0000305"
FT CONFLICT 620
FT /note="M -> V (in Ref. 2; BAA96031)"
FT /evidence="ECO:0000305"
FT CONFLICT 718
FT /note="A -> V (in Ref. 3; CAE45880)"
FT /evidence="ECO:0000305"
FT CONFLICT 760
FT /note="A -> S (in Ref. 3; CAH18244)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 931 AA; 104987 MW; E0D67A555FD20134 CRC64;
MASPGIEVEL LGKGHSDLGE VAPEIKASER RTAVAIADLE WREMEGDDCE FRYGDGTNEA
QDNDFPTVER SRLQEMLSLL GLETYQVQKL SLQDSLQISF DSMKNWAPQV PKDLPWNFLR
KLQALNADAR NTTMVLDVLP DARPVEKESQ MEEEIIYWDP ADDLAADIYS FSELPTPDTP
VNPLDLLCAL LLSSDSFLQQ EIALKMALCQ FALPLVLPDS ENHYHTFLLW AMRGIVRTWW
SQPPRGMGSF REDSVVLSRA PAFAFVRMDV SSNSKSQLLN AVLSPGHRQW DCFWHRDLNL
GTNAREISDG LVEISWFFPS GREDLDIFPE PVAFLNLRGD IGSHWLQFKL LTEISSAVFI
LTDNISKKEY KLLYSMKEST TKYYFILSPY RGKRNTNLRF LNKLIPVLKI DHSHVLVKVS
STDSDSFVKR IRAIVGNVLR APCRRVSVED MAHAARKLGL KVDEDCEECQ KAKDRMERIT
RKIKDSDAYR RDELRLQGDP WRKAAQVEKE FCQLQWAVDP PEKHRAELRR RLLELRMQQN
GHDPSSGVQE FISGISSPSL SEKQYFLRWM EWGLARVAQP RLRQPPETLL TLRPKHGGTT
DVGEPLWPEP LGVEHFLREM GQFYEAESCL VEAGRLPAGQ RRFAHFPGLA SELLLTGLPL
ELIDGSTLSM PVRWVTGLLK ELHVRLERRS RLVVLSTVGV PGTGKSTLLN TMFGLRFATG
KSCGPRGAFM QLITVAEGFS QDLGCDHILV IDSGGLIGGA LTSAGDRFEL EASLATLLMG
LSNVTVISLA ETKDIPAAIL HAFLRLEKTG HMPNYQFVYQ NLHDVSVPGP RPRDKRQLLD
PPGDLSRAAA QMEKQGDGFR ALAGLAFCDP EKQHIWHIPG LWHGAPPMAA VSLAYSEAIF
ELKRCLLENI RNGLSNQNKN IQQLIELVRR L
