URGCP_MOUSE
ID URGCP_MOUSE Reviewed; 926 AA.
AC Q5NCI0; A0PJ66; Q3TLI5; Q8C9K3; Q8CBP7; Q8CC98;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-2005, sequence version 1.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=Up-regulator of cell proliferation;
DE AltName: Full=HBV X protein up-regulated gene 4 protein homolog;
DE AltName: Full=HBxAg up-regulated gene 4 protein homolog;
GN Name=Urgcp; Synonyms=Urg4;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1] {ECO:0000305, ECO:0000312|EMBL:BAE38807.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J {ECO:0000312|EMBL:BAC31109.1};
RC TISSUE=Cecum {ECO:0000312|EMBL:BAC28370.1},
RC Mammary gland {ECO:0000312|EMBL:BAE38807.1},
RC Thymus {ECO:0000312|EMBL:BAC31109.1}, and
RC Urinary bladder {ECO:0000312|EMBL:BAC29111.1};
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3] {ECO:0000305, ECO:0000312|EMBL:AAH16589.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 518-816 (ISOFORMS 1/2).
RC TISSUE=Mammary tumor {ECO:0000312|EMBL:AAH16589.1};
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in cell cycle progression through the
CC regulation of cyclin D1 expression. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q8TCY9}. Nucleus
CC {ECO:0000250|UniProtKB:Q8TCY9}. Note=In epithelial cells localized
CC predominantly in the cytoplasm and occasionally in nuclei.
CC {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1 {ECO:0000269|PubMed:16141072};
CC IsoId=Q5NCI0-1; Sequence=Displayed;
CC Name=2 {ECO:0000269|PubMed:16141072};
CC IsoId=Q5NCI0-2; Sequence=VSP_052800;
CC -!- SIMILARITY: Belongs to the TRAFAC class dynamin-like GTPase
CC superfamily. Very large inducible GTPase (VLIG) family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH16589.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};
CC Sequence=BAC28370.1; Type=Frameshift; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK033577; BAC28370.1; ALT_FRAME; mRNA.
DR EMBL; AK035580; BAC29111.1; -; mRNA.
DR EMBL; AK041953; BAC31109.1; -; mRNA.
DR EMBL; AK166495; BAE38807.1; -; mRNA.
DR EMBL; AL627069; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC016589; AAH16589.1; ALT_SEQ; mRNA.
DR CCDS; CCDS36104.1; -. [Q5NCI0-1]
DR CCDS; CCDS36105.1; -. [Q5NCI0-2]
DR RefSeq; NP_001071129.1; NM_001077661.1. [Q5NCI0-2]
DR RefSeq; NP_848738.2; NM_178623.3. [Q5NCI0-1]
DR RefSeq; XP_006514877.1; XM_006514814.3.
DR RefSeq; XP_006514878.1; XM_006514815.3. [Q5NCI0-2]
DR RefSeq; XP_011242057.1; XM_011243755.2. [Q5NCI0-2]
DR AlphaFoldDB; Q5NCI0; -.
DR BioGRID; 215114; 1.
DR STRING; 10090.ENSMUSP00000091053; -.
DR iPTMnet; Q5NCI0; -.
DR PhosphoSitePlus; Q5NCI0; -.
DR EPD; Q5NCI0; -.
DR MaxQB; Q5NCI0; -.
DR PaxDb; Q5NCI0; -.
DR PeptideAtlas; Q5NCI0; -.
DR PRIDE; Q5NCI0; -.
DR ProteomicsDB; 298206; -. [Q5NCI0-1]
DR ProteomicsDB; 298207; -. [Q5NCI0-2]
DR Antibodypedia; 7083; 170 antibodies from 24 providers.
DR DNASU; 72046; -.
DR Ensembl; ENSMUST00000053427; ENSMUSP00000055821; ENSMUSG00000049680. [Q5NCI0-2]
DR Ensembl; ENSMUST00000093362; ENSMUSP00000091053; ENSMUSG00000049680. [Q5NCI0-1]
DR Ensembl; ENSMUST00000118076; ENSMUSP00000113589; ENSMUSG00000049680. [Q5NCI0-2]
DR Ensembl; ENSMUST00000120306; ENSMUSP00000113060; ENSMUSG00000049680. [Q5NCI0-2]
DR Ensembl; ENSMUST00000170116; ENSMUSP00000133216; ENSMUSG00000049680. [Q5NCI0-2]
DR GeneID; 72046; -.
DR KEGG; mmu:72046; -.
DR UCSC; uc007hwu.1; mouse. [Q5NCI0-1]
DR CTD; 55665; -.
DR MGI; MGI:1919296; Urgcp.
DR VEuPathDB; HostDB:ENSMUSG00000049680; -.
DR eggNOG; ENOG502QU4G; Eukaryota.
DR GeneTree; ENSGT00940000154390; -.
DR HOGENOM; CLU_002276_0_0_1; -.
DR InParanoid; Q5NCI0; -.
DR OMA; QENTDGT; -.
DR OrthoDB; 31942at2759; -.
DR PhylomeDB; Q5NCI0; -.
DR TreeFam; TF335271; -.
DR BioGRID-ORCS; 72046; 5 hits in 72 CRISPR screens.
DR ChiTaRS; Urgcp; mouse.
DR PRO; PR:Q5NCI0; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q5NCI0; protein.
DR Bgee; ENSMUSG00000049680; Expressed in substantia nigra and 219 other tissues.
DR ExpressionAtlas; Q5NCI0; baseline and differential.
DR Genevisible; Q5NCI0; MM.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR030383; G_VLIG_dom.
DR InterPro; IPR006073; GTP-bd.
DR InterPro; IPR027417; P-loop_NTPase.
DR PRINTS; PR00326; GTP1OBG.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS51717; G_VLIG; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cell cycle; Cytoplasm; GTP-binding;
KW Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome.
FT CHAIN 1..926
FT /note="Up-regulator of cell proliferation"
FT /id="PRO_0000337149"
FT DOMAIN 689..924
FT /note="VLIG-type G"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01054"
FT MOD_RES 3
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8TCY9"
FT VAR_SEQ 1..43
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_052800"
FT CONFLICT 60
FT /note="A -> T (in Ref. 1; BAE38807)"
FT /evidence="ECO:0000305"
FT CONFLICT 291
FT /note="D -> Y (in Ref. 1; BAC29111)"
FT /evidence="ECO:0000305"
FT CONFLICT 518
FT /note="P -> T (in Ref. 1; BAC29111)"
FT /evidence="ECO:0000305"
FT CONFLICT 684
FT /note="T -> A (in Ref. 1; BAE38807)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 926 AA; 104683 MW; 34C1CC4AAC0D131C CRC64;
MASPGIEVEL LVKGHSDLGE VAPEVKPSDS QTSVAIADLE WREMEGDDCG FHYGDGTNEA
QDNDFPTVER SRLQEMLSLL GLETYQAQKL TLQDSLQISF DSMKNWAPQV PKDLPWHFLR
KLQALNAEAR NTTMVLDVPP EAWPAEKESQ AEEEMMYWDP AEDVAADIYS FSELPMPDTP
VNPLDLLCAL LLSSDTFLQQ EVLLKMSLCQ FALPLVLPDS ENHYHTFLLW ALRGVVRTWW
FQPLRSLGSF REDSVVLSRV PTFAFVRMDV SSNSKSQLLN AVLSPARRQW DCFWHRDLNL
GTNPREISDG LVEISWFFPS GKEDLDVFPE PMAFLNLRGD IGSHWLQFKL LTEVSSAVFI
LTDNISKKEY KLLYSMKEST TKYYFILSPY RGKRNTNLRF LNRLIPVLKI DHSHVLVKVS
STDSEGFVRR IRAIMCSVAR SPCRRVSVED MAHAARKLGL RVDEDFEECQ KAKDRMEKIL
RKIKDVDAYK RDELRLQGEP ARRAAQAERE FCQLQWVPEP PEKHRAELRR RVLELRVQQN
GQEPTSGVQE FILGISSPSP SERQYFLRWM EWGLARLGQP RPRQPPETLL TLRPKLGGPS
DLTEPLWPEP LGVEHFLREM GQFYEAESCL IEAGRLPAGQ RRFAHFPGVA VELLLGGLPL
ELVDGATLSI PVRWVTGLLK ELHTRLDRRS RLVVLSALGV PGTGKSTLLN TMFGLKFATG
RSCSPRGAFM QLLPVAEGFS QDLGCDQILV IDSGGLISGA LASAGDRFEL EASLATLLMG
LSNVTVVSLA ETKDIPPAVL HAFLRLEKMG HMPNYQFVYQ NLHDLPVPSP KPRDRRQLLD
PPSDLSRATH LEKQGGGFRT LAGLAERQHV WHIPALWHGA PPMAAVSLGY SEAIFELKRC
LLENIRNGLS NQNQNIQQLI ELLRRL
