ID   URGCP_PONAB             Reviewed;         931 AA.
AC   Q5RFJ8;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 58.
DE   RecName: Full=Up-regulator of cell proliferation;
DE   AltName: Full=HBV X protein up-regulated gene 4 protein homolog;
DE   AltName: Full=HBxAg up-regulated gene 4 protein homolog;
GN   Name=URGCP; Synonyms=URG4;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1] {ECO:0000312|EMBL:CAH89459.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney {ECO:0000312|EMBL:CAH89459.1};
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May be involved in cell cycle progression through the
CC       regulation of cyclin D1 expression. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q8TCY9}. Nucleus
CC       {ECO:0000250|UniProtKB:Q8TCY9}. Note=In epithelial cells localized
CC       predominantly in the cytoplasm and occasionally in nuclei.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TRAFAC class dynamin-like GTPase
CC       superfamily. Very large inducible GTPase (VLIG) family. {ECO:0000305}.
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DR   EMBL; CR857158; CAH89459.1; -; mRNA.
DR   RefSeq; NP_001127150.1; NM_001133678.1.
DR   AlphaFoldDB; Q5RFJ8; -.
DR   STRING; 9601.ENSPPYP00000019730; -.
DR   GeneID; 100174201; -.
DR   KEGG; pon:100174201; -.
DR   CTD; 55665; -.
DR   eggNOG; ENOG502QU4G; Eukaryota.
DR   InParanoid; Q5RFJ8; -.
DR   OrthoDB; 31942at2759; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR030383; G_VLIG_dom.
DR   InterPro; IPR006073; GTP-bd.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PRINTS; PR00326; GTP1OBG.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS51717; G_VLIG; 1.
PE   2: Evidence at transcript level;
KW   Cell cycle; Cytoplasm; GTP-binding; Nucleotide-binding; Nucleus;
KW   Phosphoprotein; Reference proteome.
FT   CHAIN           1..931
FT                   /note="Up-regulator of cell proliferation"
FT                   /id="PRO_0000337150"
FT   DOMAIN          689..929
FT                   /note="VLIG-type G"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01054"
FT   MOD_RES         3
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8TCY9"
SQ   SEQUENCE   931 AA;  105075 MW;  B7C1219290D92D27 CRC64;
     MASPGIEVEL LGKGHSDLGE VAPEIKASER RTAVAIADLE WREMEGDDCE FRYGDGTNEA
     QDNDFPTVER SRLQEMLSLL GLETYQVQKL SLQDSLQISF DSMKNWAPQV PKDLPWNFLR
     KLQALNADAR NTTMVLDVLP DARPVEKESQ MEEEIIYWDP ADDLAADIYS FSELPTPDTP
     VNPLDLLCAL LLSSDSFLQQ EIALKMALCQ FALPLVLPDS ENHYHTFLLW AMRGIMRTWW
     SQPPRGVGSF REDSVVLSRA PAFAFVRMDV SSNSKSQLLN AVLSPGHRQW DCFWHRDLNL
     GTNAREISDG LVEISWFFPS GREDLDIFPE PVAFLNLRGD IGSHWLQFKL LTEISSAVFI
     LTDNISKKEY KLLYSMKEST TKYYFILSPY RGKRNTNLRF LNKLIPVLKI DHSHVLVKVS
     STDSDSFVKR IRAIVGNVLR APCRRVSVED MAHAARKLGL KVDEDCEECQ KAKDRMERIT
     RKIKDSDAYR RDELRLQGDP WRKAAQVEKE FCQLQWAVDP PEKHRAELRR RLLELRMQQD
     GHDPSLGVQE FISGISSPSL SEKQYFLRWM EWGLARVAQL RLRQPPETLL TLRPKHGGTT
     DLGEPLWPEP LGVEHFLREM GQFYEAESCL VEAGRLPAGQ RRFAHFPGLA SELLLTGLPL
     ELIDGSTLSM PVRWVTGLLK ELHVRLERRS RLVVLSTVGV PGTGKSTLLN TMFGLRFATG
     KSCSPRGAFM QLITVAEGFS QDLGCDHILV IDSGGLIGGA LMSAGDRFEL EASLATLLMG
     LSNVTVISLA ETKDIPAAIL HAFLRLEKTG HMPNYQFVYQ NLHDVSVPGP RPRDKRQLLD
     PPGDLGRAAA QMEKQGDGFR ALAGLAFCDP EKQHIWHIPG LWHGAPPMAA VSLAYSEAIF
     ELKRCLLENI RNGLSNQNKN IQQLIELVRR L