ID   URIC_HALJB              Reviewed;         306 AA.
AC   D8JBB7;
DT   27-JUL-2011, integrated into UniProtKB/Swiss-Prot.
DT   27-JUL-2011, sequence version 2.
DT   03-AUG-2022, entry version 55.
DE   RecName: Full=Uricase;
DE            EC=1.7.3.3;
DE   AltName: Full=Urate oxidase;
GN   OrderedLocusNames=HacjB3_16061;
OS   Halalkalicoccus jeotgali (strain DSM 18796 / CECT 7217 / JCM 14584 / KCTC
OS   4019 / B3).
OG   Plasmid 1.
OC   Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC   Halobacteriaceae; Halalkalicoccus.
OX   NCBI_TaxID=795797;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 18796 / CECT 7217 / JCM 14584 / KCTC 4019 / B3;
RX   PubMed=20601480; DOI=10.1128/jb.00663-10;
RA   Roh S.W., Nam Y.D., Nam S.H., Choi S.H., Park H.S., Bae J.W.;
RT   "Complete genome sequence of Halalkalicoccus jeotgali B3(T), an extremely
RT   halophilic archaeon.";
RL   J. Bacteriol. 192:4528-4529(2010).
CC   -!- FUNCTION: Catalyzes the oxidation of uric acid to 5-hydroxyisourate,
CC       which is further processed to form (S)-allantoin. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + O2 + urate = 5-hydroxyisourate + H2O2;
CC         Xref=Rhea:RHEA:21368, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379,
CC         ChEBI:CHEBI:16240, ChEBI:CHEBI:17775, ChEBI:CHEBI:18072; EC=1.7.3.3;
CC   -!- PATHWAY: Purine metabolism; urate degradation; (S)-allantoin from
CC       urate: step 1/3.
CC   -!- SIMILARITY: Belongs to the uricase family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=ADJ16570.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; CP002063; ADJ16570.1; ALT_INIT; Genomic_DNA.
DR   AlphaFoldDB; D8JBB7; -.
DR   SMR; D8JBB7; -.
DR   STRING; 795797.C497_01190; -.
DR   EnsemblBacteria; ADJ16570; ADJ16570; HacjB3_16061.
DR   KEGG; hje:HacjB3_16061; -.
DR   eggNOG; arCOG11422; Archaea.
DR   HOGENOM; CLU_048151_0_0_2; -.
DR   UniPathway; UPA00394; UER00650.
DR   Proteomes; UP000000390; Plasmid 1.
DR   GO; GO:0004846; F:urate oxidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006144; P:purine nucleobase metabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0019628; P:urate catabolic process; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR002042; Uricase.
DR   PANTHER; PTHR42874; PTHR42874; 1.
DR   Pfam; PF01014; Uricase; 2.
DR   PIRSF; PIRSF000241; Urate_oxidase; 1.
DR   PRINTS; PR00093; URICASE.
DR   TIGRFAMs; TIGR03383; urate_oxi; 1.
PE   3: Inferred from homology;
KW   Oxidoreductase; Plasmid; Purine metabolism; Reference proteome.
FT   CHAIN           1..306
FT                   /note="Uricase"
FT                   /id="PRO_0000411961"
FT   REGION          281..306
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        5
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000250|UniProtKB:D0VWQ1"
FT   ACT_SITE        65
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000250|UniProtKB:D0VWQ1"
FT   BINDING         65..66
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250|UniProtKB:D0VWQ1"
FT   BINDING         175
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250|UniProtKB:D0VWQ1"
FT   BINDING         192
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250|UniProtKB:D0VWQ1"
FT   BINDING         240..241
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250|UniProtKB:D0VWQ1"
SQ   SEQUENCE   306 AA;  35081 MW;  8986D9831931C1B0 CRC64;
     MNYGKEQVAV YRTYANPLEG VRTIPESSFD GRDNILFGLE VRVQFEGEEF LPSFSEADNT
     TVVATDSMKN FVLHQAGEYE GATAEGFLHF VGTEFLETYP HVEAVTMSAT EYPFDERPVP
     GDDGFDPSDL VFRVSDDESA FGEIYLEREG DELRFEEQTS GVTEIELVKV KENSFTGYVQ
     DEYTTLPERE DRALYISLDV FWTYSDPEDA LGDEPQRYVP AEQVRDIAQV VFHEVNSNSI
     QDLIYQIGLR VLERYPQLES VNFEANNRTW IEVRDDLDGD AKVLREPPRP TGYQQFSMDR
     SDLEEQ