URK_THET8
ID URK_THET8 Reviewed; 211 AA.
AC Q5SKR5;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 108.
DE RecName: Full=Uridine kinase {ECO:0000255|HAMAP-Rule:MF_00551};
DE EC=2.7.1.48 {ECO:0000255|HAMAP-Rule:MF_00551};
DE AltName: Full=Cytidine monophosphokinase {ECO:0000255|HAMAP-Rule:MF_00551};
DE AltName: Full=Uridine monophosphokinase {ECO:0000255|HAMAP-Rule:MF_00551};
GN Name=udk {ECO:0000255|HAMAP-Rule:MF_00551}; OrderedLocusNames=TTHA0578;
OS Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8).
OC Bacteria; Deinococcus-Thermus; Deinococci; Thermales; Thermaceae; Thermus.
OX NCBI_TaxID=300852;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 27634 / DSM 579 / HB8;
RA Masui R., Kurokawa K., Nakagawa N., Tokunaga F., Koyama Y., Shibata T.,
RA Oshima T., Yokoyama S., Yasunaga T., Kuramitsu S.;
RT "Complete genome sequence of Thermus thermophilus HB8.";
RL Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + uridine = ADP + H(+) + UMP; Xref=Rhea:RHEA:16825,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:16704, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:57865, ChEBI:CHEBI:456216; EC=2.7.1.48;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00551};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + cytidine = ADP + CMP + H(+); Xref=Rhea:RHEA:24674,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:17562, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:60377, ChEBI:CHEBI:456216; EC=2.7.1.48;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00551};
CC -!- PATHWAY: Pyrimidine metabolism; CTP biosynthesis via salvage pathway;
CC CTP from cytidine: step 1/3. {ECO:0000255|HAMAP-Rule:MF_00551}.
CC -!- PATHWAY: Pyrimidine metabolism; UMP biosynthesis via salvage pathway;
CC UMP from uridine: step 1/1. {ECO:0000255|HAMAP-Rule:MF_00551}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00551}.
CC -!- SIMILARITY: Belongs to the uridine kinase family. {ECO:0000255|HAMAP-
CC Rule:MF_00551}.
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DR EMBL; AP008226; BAD70401.1; -; Genomic_DNA.
DR RefSeq; WP_011172663.1; NC_006461.1.
DR RefSeq; YP_143844.1; NC_006461.1.
DR PDB; 3ASY; X-ray; 2.40 A; A/B=1-211.
DR PDB; 3ASZ; X-ray; 2.25 A; A/B=1-211.
DR PDB; 3W34; X-ray; 1.91 A; A/B=1-211.
DR PDB; 3W8R; X-ray; 2.50 A; A/B=1-211.
DR PDBsum; 3ASY; -.
DR PDBsum; 3ASZ; -.
DR PDBsum; 3W34; -.
DR PDBsum; 3W8R; -.
DR AlphaFoldDB; Q5SKR5; -.
DR SMR; Q5SKR5; -.
DR STRING; 300852.55771960; -.
DR EnsemblBacteria; BAD70401; BAD70401; BAD70401.
DR GeneID; 3168643; -.
DR KEGG; ttj:TTHA0578; -.
DR PATRIC; fig|300852.9.peg.577; -.
DR eggNOG; COG0572; Bacteria.
DR HOGENOM; CLU_021278_1_2_0; -.
DR OMA; TTLKPMH; -.
DR PhylomeDB; Q5SKR5; -.
DR BRENDA; 2.7.1.48; 2305.
DR UniPathway; UPA00574; UER00637.
DR UniPathway; UPA00579; UER00640.
DR EvolutionaryTrace; Q5SKR5; -.
DR Proteomes; UP000000532; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016773; F:phosphotransferase activity, alcohol group as acceptor; IEA:InterPro.
DR GO; GO:0004849; F:uridine kinase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0044211; P:CTP salvage; IEA:UniProtKB-UniPathway.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0044206; P:UMP salvage; IEA:UniProtKB-UniPathway.
DR CDD; cd02023; UMPK; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR HAMAP; MF_00551; Uridine_kinase; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR006083; PRK/URK.
DR InterPro; IPR026008; Uridine_kinase.
DR InterPro; IPR000764; Uridine_kinase-like.
DR Pfam; PF00485; PRK; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR00235; udk; 1.
PE 1: Evidence at protein level;
KW 3D-structure; ATP-binding; Cytoplasm; Kinase; Nucleotide-binding;
KW Reference proteome; Transferase.
FT CHAIN 1..211
FT /note="Uridine kinase"
FT /id="PRO_1000081978"
FT BINDING 13..20
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00551"
FT STRAND 7..14
FT /evidence="ECO:0007829|PDB:3W34"
FT HELIX 19..30
FT /evidence="ECO:0007829|PDB:3W34"
FT HELIX 31..33
FT /evidence="ECO:0007829|PDB:3W34"
FT STRAND 34..38
FT /evidence="ECO:0007829|PDB:3W34"
FT HELIX 39..41
FT /evidence="ECO:0007829|PDB:3W34"
FT HELIX 51..56
FT /evidence="ECO:0007829|PDB:3W34"
FT HELIX 62..64
FT /evidence="ECO:0007829|PDB:3W34"
FT HELIX 67..78
FT /evidence="ECO:0007829|PDB:3W34"
FT STRAND 83..89
FT /evidence="ECO:0007829|PDB:3W34"
FT TURN 90..93
FT /evidence="ECO:0007829|PDB:3W34"
FT STRAND 94..102
FT /evidence="ECO:0007829|PDB:3W34"
FT STRAND 106..112
FT /evidence="ECO:0007829|PDB:3W34"
FT TURN 113..116
FT /evidence="ECO:0007829|PDB:3W34"
FT HELIX 119..122
FT /evidence="ECO:0007829|PDB:3W34"
FT STRAND 126..132
FT /evidence="ECO:0007829|PDB:3W34"
FT HELIX 135..149
FT /evidence="ECO:0007829|PDB:3W34"
FT HELIX 154..163
FT /evidence="ECO:0007829|PDB:3W34"
FT HELIX 165..171
FT /evidence="ECO:0007829|PDB:3W34"
FT HELIX 174..179
FT /evidence="ECO:0007829|PDB:3W34"
FT STRAND 181..186
FT /evidence="ECO:0007829|PDB:3W34"
FT HELIX 191..209
FT /evidence="ECO:0007829|PDB:3W34"
SQ SEQUENCE 211 AA; 23674 MW; 8A64A64FF033E6B0 CRC64;
MSAPKPFVIG IAGGTASGKT TLAQALARTL GERVALLPMD HYYKDLGHLP LEERLRVNYD
HPDAFDLALY LEHAQALLRG LPVEMPVYDF RAYTRSPRRT PVRPAPVVIL EGILVLYPKE
LRDLMDLKVF VDADADERFI RRLKRDVLER GRSLEGVVAQ YLEQVKPMHL HFVEPTKRYA
DVIVPRGGQN PVALEMLAAK ALARLARMGA A
