ID   US02_HHV11              Reviewed;         291 AA.
AC   P06485; B9VQJ6; Q09I75;
DT   01-JAN-1988, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   29-SEP-2021, entry version 85.
DE   RecName: Full=Protein US2;
GN   ORFNames=US2;
OS   Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Alphaherpesvirinae; Simplexvirus.
OX   NCBI_TaxID=10299;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=2984429; DOI=10.1016/0022-2836(85)90320-1;
RA   McGeoch D.J., Dolan A., Donald S., Rixon F.J.;
RT   "Sequence determination and genetic content of the short unique region in
RT   the genome of herpes simplex virus type 1.";
RL   J. Mol. Biol. 181:1-13(1985).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2839594; DOI=10.1099/0022-1317-69-7-1531;
RA   McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C., McNab D.,
RA   Perry L.J., Scott J.E., Taylor P.;
RT   "The complete DNA sequence of the long unique region in the genome of
RT   herpes simplex virus type 1.";
RL   J. Gen. Virol. 69:1531-1574(1988).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Nonneuroinvasive mutant HF10;
RX   PubMed=17218138; DOI=10.1016/j.micinf.2006.10.019;
RA   Ushijima Y., Luo C., Goshima F., Yamauchi Y., Kimura H., Nishiyama Y.;
RT   "Determination and analysis of the DNA sequence of highly attenuated herpes
RT   simplex virus type 1 mutant HF10, a potential oncolytic virus.";
RL   Microbes Infect. 9:142-149(2007).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=17 syn+;
RA   Cunningham C., Davison A.J.;
RT   "Herpes simplex virus type 1 bacterial artificial chromosome.";
RL   Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   PROTEIN SEQUENCE OF 2-20; 21-35 AND 154-168, CLEAVAGE OF INITIATOR
RP   METHIONINE, AND ACETYLATION AT GLY-2.
RA   Quadroni M., Greco A., Bienvenut W.V.;
RL   Submitted (NOV-2005) to UniProtKB.
CC   -!- SUBUNIT: Interacts with host KRT18. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Host cytoplasm {ECO:0000250}. Host nucleus
CC       {ECO:0000250}. Note=Found in association with the nuclear matrix of
CC       infected cells. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the herpesviridae HHV-1 US2 protein family.
CC       {ECO:0000305}.
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DR   EMBL; X02138; CAA26056.1; -; Genomic_DNA.
DR   EMBL; L00036; AAA96686.1; -; Genomic_DNA.
DR   EMBL; X14112; CAA32279.1; -; Genomic_DNA.
DR   EMBL; DQ889502; ABI63520.1; -; Genomic_DNA.
DR   EMBL; FJ593289; ACM62291.1; -; Genomic_DNA.
DR   PIR; A05238; QQBE72.
DR   RefSeq; YP_009137137.1; NC_001806.2.
DR   BioGRID; 971433; 2.
DR   PRIDE; P06485; -.
DR   DNASU; 2703399; -.
DR   GeneID; 2703399; -.
DR   KEGG; vg:2703399; -.
DR   Proteomes; UP000009294; Genome.
DR   Proteomes; UP000180652; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   InterPro; IPR003485; Herpes_US2_varicellovirus.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   Pfam; PF02476; US2; 1.
DR   SUPFAM; SSF48726; SSF48726; 1.
PE   1: Evidence at protein level;
KW   Acetylation; Direct protein sequencing; Host cytoplasm; Host nucleus;
KW   Host-virus interaction; Reference proteome.
FT   INIT_MET        1
FT                   /note="Removed; by host"
FT                   /evidence="ECO:0000269|Ref.5"
FT   CHAIN           2..291
FT                   /note="Protein US2"
FT                   /id="PRO_0000116126"
FT   REGION          251..270
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         2
FT                   /note="N-acetylglycine; by host; partial"
FT                   /evidence="ECO:0000269|Ref.5"
FT   VARIANT         80
FT                   /note="R -> C (in strain: Nonneuroinvasive mutant HF10)"
FT   VARIANT         172
FT                   /note="E -> K (in strain: Nonneuroinvasive mutant HF10)"
SQ   SEQUENCE   291 AA;  32471 MW;  7227D9F051FD3A78 CRC64;
     MGVVVVNVMT LLDQNNALPR TSVDASPALW SFLLRQCRIL ASEPLGTPVV VRPANLRRLA
     EPLMDLPKPT RPIVRTRSCR CPPNTTTGLF AEDSPLESTE VVDAVACFRL LHRDQPSPPR
     LYHLWVVGAA DLCVPFLEYA QKIRLGVRFI AIKTPDAWVG EPWAVPTRFL PEWTVAWTPF
     PAAPNHPLET LLSRYEYQYG VVLPGTNGRE RDCMRWLRSL IALHKPHPAT PGPLTTSHPV
     RRPCCACMGM PEVPDEQPTS PGRGPQETDP LIAVRGERPR LPHICYPVTT L