US02_HHV2H
ID US02_HHV2H Reviewed; 291 AA.
AC P13292;
DT 01-JAN-1990, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 3.
DT 23-FEB-2022, entry version 80.
DE RecName: Full=Protein US2;
GN ORFNames=US2;
OS Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2).
OC Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC Herpesvirales; Herpesviridae; Alphaherpesvirinae; Simplexvirus.
OX NCBI_TaxID=10315;
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=3027242; DOI=10.1099/0022-1317-68-1-19;
RA McGeoch D.J., Moss H.W.M., McNab D., Frame M.C.;
RT "DNA sequence and genetic content of the HindIII l region in the short
RT unique component of the herpes simplex virus type 2 genome: identification
RT of the gene encoding glycoprotein G, and evolutionary comparisons.";
RL J. Gen. Virol. 68:19-38(1987).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=9499055; DOI=10.1128/jvi.72.3.2010-2021.1998;
RA Dolan A., Jamieson F.E., Cunningham C., Barnett B.C., McGeoch D.J.;
RT "The genome sequence of herpes simplex virus type 2.";
RL J. Virol. 72:2010-2021(1998).
RN [3]
RP SUBCELLULAR LOCATION.
RX PubMed=9820154; DOI=10.1099/0022-1317-79-11-2777;
RA Jiang Y.M., Yamada H., Goshima F., Daikoku T., Oshima S., Wada K.,
RA Nishiyama Y.;
RT "Characterization of the herpes simplex virus type 2 (HSV-2) US2 gene
RT product and a US2-deficient HSV-2 mutant.";
RL J. Gen. Virol. 79:2777-2784(1998).
RN [4]
RP INTERACTION WITH HOST KRT18.
RX PubMed=11765921; DOI=10.1007/s007050170030;
RA Goshima F., Watanabe D., Suzuki H., Takakuwa H., Yamada H., Nishiyama Y.;
RT "The US2 gene product of herpes simplex virus type 2 interacts with
RT cytokeratin 18.";
RL Arch. Virol. 146:2201-2209(2001).
RN [5]
RP SUBCELLULAR LOCATION, AND FUNCTION.
RX PubMed=23785212; DOI=10.1128/jvi.00994-13;
RA Kang M.H., Roy B.B., Finnen R.L., Le Sage V., Johnston S.M., Zhang H.,
RA Banfield B.W.;
RT "The Us2 gene product of herpes simplex virus 2 is a membrane-associated
RT ubiquitin-interacting protein.";
RL J. Virol. 87:9590-9603(2013).
RN [6]
RP FUNCTION.
RX PubMed=28827540; DOI=10.1038/s41598-017-08856-4;
RA Lu X., Huang C., Zhang Y., Lin Y., Wang X., Li Q., Liu S., Tang J.,
RA Zhou L.;
RT "The Us2 Gene Product of herpes dimplex virus 2 modulates NF-kappaB
RT activation by targeting TAK1.";
RL Sci. Rep. 7:8396-8396(2017).
CC -!- FUNCTION: Plays a role in the activation of the host NF-kappa-B pathway
CC by interacting with and thus activating the component MAP3K7.
CC {ECO:0000269|PubMed:28827540}.
CC -!- SUBUNIT: Interacts with host KRT18 (PubMed:11765921). Interacts with
CC host MAP3K7; this interaction induces host NF-kappa-B pathway
CC (PubMed:28827540). {ECO:0000269|PubMed:11765921,
CC ECO:0000269|PubMed:28827540}.
CC -!- SUBCELLULAR LOCATION: Virion {ECO:0000269|PubMed:23785212}. Host
CC cytoplasm {ECO:0000269|PubMed:23785212, ECO:0000269|PubMed:9820154}.
CC Host cell surface {ECO:0000269|PubMed:23785212}. Host nucleus
CC {ECO:0000269|PubMed:9820154}. Note=Found in association with the
CC nuclear matrix of infected cells.
CC -!- SIMILARITY: Belongs to the herpesviridae HHV-1 US2 protein family.
CC {ECO:0000305}.
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DR EMBL; X04798; CAA28487.1; -; Genomic_DNA.
DR EMBL; Z86099; CAB06709.1; -; Genomic_DNA.
DR PIR; A43674; A43674.
DR RefSeq; YP_009137214.1; NC_001798.2.
DR PRIDE; P13292; -.
DR DNASU; 1487354; -.
DR GeneID; 1487354; -.
DR KEGG; vg:1487354; -.
DR Proteomes; UP000001874; Genome.
DR GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0044228; C:host cell surface; IEA:UniProtKB-SubCell.
DR GO; GO:0039652; P:induction by virus of host NF-kappaB cascade; IDA:UniProtKB.
DR InterPro; IPR003485; Herpes_US2_varicellovirus.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR Pfam; PF02476; US2; 1.
DR SUPFAM; SSF48726; SSF48726; 1.
PE 1: Evidence at protein level;
KW Acetylation; Activation of host NF-kappa-B by virus; Host cytoplasm;
KW Host nucleus; Host-virus interaction; Reference proteome; Virion.
FT INIT_MET 1
FT /note="Removed; by host"
FT /evidence="ECO:0000250"
FT CHAIN 2..291
FT /note="Protein US2"
FT /id="PRO_0000116127"
FT REGION 223..281
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 2
FT /note="N-acetylglycine; by host"
FT /evidence="ECO:0000250"
SQ SEQUENCE 291 AA; 32781 MW; 0F47AB65F40AA9A6 CRC64;
MGVVVVSVVT LLDQRNALPR TSADASPALW SFLLRQCRIL ASEPLGTPVV VRPANLRRLA
EPLMDLPKFT RPIVRTRSCR CPPNTTTGLF AEDDPLESIE ILDAPACFRL LHQERPGPHR
LYHLWVVGAA DLCVPFFEYA QKTRLGFRFI ATKTNDAWVG EPWPLPDRFL PERTVSWTPF
PAAPNHPLEN LLSRYEYQYG VVVPGDRERS CLRWLRSLVA PHNKPRPASS RPHPATHPTQ
RPCFTCMGRP EIPDEPSWQT GDDDPQNPGP PLAVGDEWPP SSHVCYPITN L
