ID   US07_HCMVA              Reviewed;         225 AA.
AC   P09731; Q7M6G4;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1989, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=Unique short US7 glycoprotein;
DE   AltName: Full=Protein HXLF5;
DE   AltName: Full=gpUS7;
DE   Flags: Precursor;
GN   Name=US7;
OS   Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Cytomegalovirus.
OX   NCBI_TaxID=10360;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=3031311; DOI=10.1016/0022-2836(86)90359-1;
RA   Weston K.M., Barrell B.G.;
RT   "Sequence of the short unique region, short repeats, and part of the long
RT   repeats of human cytomegalovirus.";
RL   J. Mol. Biol. 192:177-208(1986).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=2161319; DOI=10.1007/978-3-642-74980-3_6;
RA   Chee M.S., Bankier A.T., Beck S., Bohni R., Brown C.M., Cerny R.,
RA   Horsnell T., Hutchison C.A. III, Kouzarides T., Martignetti J.A.,
RA   Preddie E., Satchwell S.C., Tomlinson P., Weston K.M., Barrell B.G.;
RT   "Analysis of the protein-coding content of the sequence of human
RT   cytomegalovirus strain AD169.";
RL   Curr. Top. Microbiol. Immunol. 154:125-169(1990).
RN   [3]
RP   GENOME REANNOTATION.
RX   PubMed=12533697; DOI=10.1099/vir.0.18606-0;
RA   Davison A.J., Dolan A., Akter P., Addison C., Dargan D.J., Alcendor D.J.,
RA   McGeoch D.J., Hayward G.S.;
RT   "The human cytomegalovirus genome revisited: comparison with the chimpanzee
RT   cytomegalovirus genome.";
RL   J. Gen. Virol. 84:17-28(2003).
RN   [4]
RP   ERRATUM OF PUBMED:12533697.
RA   Davison A.J., Dolan A., Akter P., Addison C., Dargan D.J., Alcendor D.J.,
RA   McGeoch D.J., Hayward G.S.;
RL   J. Gen. Virol. 84:1053-1053(2003).
RN   [5]
RP   SUBCELLULAR LOCATION.
RX   PubMed=11992003; DOI=10.1128/jvi.76.11.5748-5758.2002;
RA   Huber M.T., Tomazin R., Wisner T., Boname J., Johnson D.C.;
RT   "Human cytomegalovirus US7, US8, US9, and US10 are cytoplasmic
RT   glycoproteins, not found at cell surfaces, and US9 does not mediate cell-
RT   to-cell spread.";
RL   J. Virol. 76:5748-5758(2002).
CC   -!- SUBCELLULAR LOCATION: Host endoplasmic reticulum membrane
CC       {ECO:0000269|PubMed:11992003}; Single-pass type I membrane protein
CC       {ECO:0000269|PubMed:11992003}.
CC   -!- SIMILARITY: Belongs to the cytomegalovirus US6 family. {ECO:0000305}.
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DR   EMBL; X17403; CAA35274.1; -; Genomic_DNA.
DR   EMBL; X04650; CAB37099.1; -; Genomic_DNA.
DR   EMBL; BK000394; DAA00224.1; -; Genomic_DNA.
DR   PIR; H26078; QQBEC8.
DR   Proteomes; UP000008991; Genome.
DR   Proteomes; UP000008992; Genome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0044386; C:integral to host endoplasmic reticulum membrane; IEA:InterPro.
DR   InterPro; IPR012536; CMV_US.
DR   Pfam; PF08001; CMV_US; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; Glycoprotein; Host endoplasmic reticulum; Host membrane;
KW   Immunoglobulin domain; Membrane; Reference proteome; Signal; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL          1..17
FT                   /evidence="ECO:0000255"
FT   CHAIN           18..225
FT                   /note="Unique short US7 glycoprotein"
FT                   /id="PRO_0000037440"
FT   TOPO_DOM        18..170
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        171..191
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        192..225
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          54..145
FT                   /note="Ig-like H-type"
FT   CARBOHYD        69
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   DISULFID        63..141
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   225 AA;  26270 MW;  D7F033C8009502BC CRC64;
     MRIQLLLVAT LVASIVATRV EDMATFRTEK QWQQDLQYRR EFVKRQLAPK PKSNIVVSHT
     VSCVIDGGNM TSVWRFEGQF NPHIASEVIL HDTSGLYNVP HEIQNDGQVL TVTVKRSAPA
     DIAKVLISLK PVQLSSGQYE CRPQLQLPWV PRPSSFMYDS YRLWYEKRWL TIILYVFMWT
     YLVTLLQYCI VRFIGTRLFY FLQRNITIRF TGKPTYNLLT YPVKG