ID   US07_HCMVM              Reviewed;         225 AA.
AC   F5HDD3;
DT   13-JUN-2012, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   03-AUG-2022, entry version 28.
DE   RecName: Full=Membrane glycoprotein US7;
DE   Flags: Precursor;
GN   Name=US7;
OS   Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Cytomegalovirus.
OX   NCBI_TaxID=295027;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15105547; DOI=10.1099/vir.0.79888-0;
RA   Dolan A., Cunningham C., Hector R.D., Hassan-Walker A.F., Lee L.,
RA   Addison C., Dargan D.J., McGeoch D.J., Gatherer D., Emery V.C.,
RA   Griffiths P.D., Sinzger C., McSharry B.P., Wilkinson G.W.G., Davison A.J.;
RT   "Genetic content of wild-type human cytomegalovirus.";
RL   J. Gen. Virol. 85:1301-1312(2004).
CC   -!- SUBCELLULAR LOCATION: Host endoplasmic reticulum membrane
CC       {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the cytomegalovirus US6 family. {ECO:0000305}.
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DR   EMBL; AY446894; AAR31696.1; -; Genomic_DNA.
DR   RefSeq; YP_081592.1; NC_006273.2.
DR   PRIDE; F5HDD3; -.
DR   DNASU; 3077535; -.
DR   GeneID; 3077535; -.
DR   KEGG; vg:3077535; -.
DR   Proteomes; UP000000938; Genome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0044386; C:integral to host endoplasmic reticulum membrane; IEA:InterPro.
DR   InterPro; IPR012536; CMV_US.
DR   Pfam; PF08001; CMV_US; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; Glycoprotein; Host endoplasmic reticulum; Host membrane;
KW   Immunoglobulin domain; Membrane; Reference proteome; Signal; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL          1..17
FT                   /evidence="ECO:0000255"
FT   CHAIN           18..225
FT                   /note="Membrane glycoprotein US7"
FT                   /id="PRO_0000417853"
FT   TOPO_DOM        18..170
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        171..191
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        192..225
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          54..145
FT                   /note="Ig-like H-type"
FT   CARBOHYD        69
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   DISULFID        63..141
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   225 AA;  26272 MW;  F82BD9D55EBEEFFD CRC64;
     MRIQLLLVST LVASIVATRV EDMATFRTEK QWQQDLQYRR EFVKRQLAPK PKSNIVVSHT
     VSCVIDGGNM TSVWRFEGQF NPHIASEVIL HDTSGLYNVP HEVQNDGQVL TVTVKRSAPA
     DIAKVLISLK PVQLSSGQYE CRPQLQLPWV PRPSSFMYDS YRLWYEKRWL TIILYVFMWT
     YLVTLLQYCI VRFIGTRLFY FLQRNITIRF TGKPTYNLLT YPVKG