ID   US08_HCMVM              Reviewed;         227 AA.
AC   F5HB52;
DT   18-APR-2012, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   03-AUG-2022, entry version 30.
DE   RecName: Full=Membrane glycoprotein US8;
DE   Flags: Precursor;
GN   Name=US8; ORFNames=HHV5wtgp139;
OS   Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Cytomegalovirus.
OX   NCBI_TaxID=295027;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Merlin;
RX   PubMed=15105547; DOI=10.1099/vir.0.79888-0;
RA   Dolan A., Cunningham C., Hector R.D., Hassan-Walker A.F., Lee L.,
RA   Addison C., Dargan D.J., McGeoch D.J., Gatherer D., Emery V.C.,
RA   Griffiths P.D., Sinzger C., McSharry B.P., Wilkinson G.W.G., Davison A.J.;
RT   "Genetic content of wild-type human cytomegalovirus.";
RL   J. Gen. Virol. 85:1301-1312(2004).
CC   -!- SUBCELLULAR LOCATION: Host endoplasmic reticulum membrane; Single-pass
CC       type I membrane protein. Host Golgi apparatus membrane {ECO:0000250};
CC       Single-pass type I membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the cytomegalovirus US6 family. {ECO:0000305}.
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DR   EMBL; AY446894; AAR31697.1; -; Genomic_DNA.
DR   RefSeq; YP_081593.1; NC_006273.2.
DR   PRIDE; F5HB52; -.
DR   DNASU; 3077426; -.
DR   GeneID; 3077426; -.
DR   KEGG; vg:3077426; -.
DR   Reactome; R-HSA-9609690; HCMV Early Events.
DR   Proteomes; UP000000938; Genome.
DR   GO; GO:0044178; C:host cell Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0044386; C:integral to host endoplasmic reticulum membrane; IEA:InterPro.
DR   InterPro; IPR012536; CMV_US.
DR   Pfam; PF08001; CMV_US; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; Glycoprotein; Host endoplasmic reticulum;
KW   Host Golgi apparatus; Host membrane; Immunoglobulin domain; Membrane;
KW   Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..227
FT                   /note="Membrane glycoprotein US8"
FT                   /id="PRO_0000416723"
FT   TOPO_DOM        22..178
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        179..199
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        200..227
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          61..155
FT                   /note="Ig-like H-type"
FT   CARBOHYD        61
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   DISULFID        69..151
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   227 AA;  26658 MW;  C2B4C229981C68AB CRC64;
     MRRWLRLLVG LGCCWVTLAH AGNPYEDDDY YYYREDEPRQ HGEPNYVAPP ARQFRFPPLN
     NVSSYQASCV VKDGVLDAVW RVQGTFYPEK GIVARVGWSG RRGRKWGRLH APECLVETTE
     AVFRLRQWVP TDLDHLTLHL VPCTKCKPMW CQPRYHIRYF SYGNSVDNLR RLHYEYRHLE
     LGVVIAIQMA MVLLLGYVLA RTVYRVSSAY YLRWHACVPQ KCEKSLC