US09_HCMVA
ID US09_HCMVA Reviewed; 247 AA.
AC P09729; Q7M6G2;
DT 01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1989, sequence version 1.
DT 03-AUG-2022, entry version 95.
DE RecName: Full=Unique short US9 glycoprotein;
DE AltName: Full=Protein HXLF3;
DE AltName: Full=gpUS9;
DE Flags: Precursor;
GN Name=US9;
OS Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5).
OC Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC Herpesvirales; Herpesviridae; Betaherpesvirinae; Cytomegalovirus.
OX NCBI_TaxID=10360;
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=3031311; DOI=10.1016/0022-2836(86)90359-1;
RA Weston K.M., Barrell B.G.;
RT "Sequence of the short unique region, short repeats, and part of the long
RT repeats of human cytomegalovirus.";
RL J. Mol. Biol. 192:177-208(1986).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=2161319; DOI=10.1007/978-3-642-74980-3_6;
RA Chee M.S., Bankier A.T., Beck S., Bohni R., Brown C.M., Cerny R.,
RA Horsnell T., Hutchison C.A. III, Kouzarides T., Martignetti J.A.,
RA Preddie E., Satchwell S.C., Tomlinson P., Weston K.M., Barrell B.G.;
RT "Analysis of the protein-coding content of the sequence of human
RT cytomegalovirus strain AD169.";
RL Curr. Top. Microbiol. Immunol. 154:125-169(1990).
RN [3]
RP FUNCTION.
RX PubMed=9621030; DOI=10.1128/jvi.72.7.5717-5727.1998;
RA Maidji E., Tugizov S., Abenes G., Jones T., Pereira L.;
RT "A novel human cytomegalovirus glycoprotein, gpUS9, which promotes cell-to-
RT cell spread in polarized epithelial cells, colocalizes with the
RT cytoskeletal proteins E-cadherin and F-actin.";
RL J. Virol. 72:5717-5727(1998).
RN [4]
RP GENOME REANNOTATION.
RX PubMed=12533697; DOI=10.1099/vir.0.18606-0;
RA Davison A.J., Dolan A., Akter P., Addison C., Dargan D.J., Alcendor D.J.,
RA McGeoch D.J., Hayward G.S.;
RT "The human cytomegalovirus genome revisited: comparison with the chimpanzee
RT cytomegalovirus genome.";
RL J. Gen. Virol. 84:17-28(2003).
RN [5]
RP ERRATUM OF PUBMED:12533697.
RA Davison A.J., Dolan A., Akter P., Addison C., Dargan D.J., Alcendor D.J.,
RA McGeoch D.J., Hayward G.S.;
RL J. Gen. Virol. 84:1053-1053(2003).
CC -!- FUNCTION: Influences cell-to-cell spread of virus in polarized cells.
CC Promotes dissemination of virus across cell-cell junctions of polarized
CC epithelial cells, maybe through the association with the cytoskeletal
CC matrix. {ECO:0000269|PubMed:9621030}.
CC -!- SUBCELLULAR LOCATION: Host endoplasmic reticulum membrane; Single-pass
CC type I membrane protein. Host cytoplasm, host cytoskeleton. Host Golgi
CC apparatus membrane; Single-pass type I membrane protein. Note=In
CC polarized cells, colocalizes with F-actin in the cortical cytoskeleton
CC which underlies lateral membranes.
CC -!- SIMILARITY: Belongs to the cytomegalovirus US6 family. {ECO:0000305}.
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DR EMBL; X17403; CAA35276.1; -; Genomic_DNA.
DR EMBL; X04650; CAB37101.1; -; Genomic_DNA.
DR EMBL; BK000394; DAA00226.1; -; Genomic_DNA.
DR PIR; A27230; QQBEF1.
DR RefSeq; YP_081594.1; NC_006273.2.
DR DNASU; 3077455; -.
DR GeneID; 3077455; -.
DR KEGG; vg:3077455; -.
DR Proteomes; UP000008991; Genome.
DR Proteomes; UP000008992; Genome.
DR GO; GO:0044178; C:host cell Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0044163; C:host cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0044386; C:integral to host endoplasmic reticulum membrane; IEA:InterPro.
DR InterPro; IPR012536; CMV_US.
DR Pfam; PF08001; CMV_US; 1.
PE 3: Inferred from homology;
KW Disulfide bond; Glycoprotein; Host cytoplasm; Host cytoskeleton;
KW Host endoplasmic reticulum; Host Golgi apparatus; Host membrane;
KW Immunoglobulin domain; Membrane; Reference proteome; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..27
FT /evidence="ECO:0000255"
FT CHAIN 28..247
FT /note="Unique short US9 glycoprotein"
FT /id="PRO_0000037442"
FT TOPO_DOM 28..192
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 193..213
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 214..247
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 72..168
FT /note="Ig-like H-type"
FT CARBOHYD 97
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT CARBOHYD 158
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT DISULFID 81..164
FT /evidence="ECO:0000250"
SQ SEQUENCE 247 AA; 28053 MW; D8B0EBA23A8B7067 CRC64;
MILWSPSTCS FFWHWCLIAV SVLSSRSKES LRLSWSSDES SASSSSRICP LSNSKSVRLP
QYPRGFGDVS GYRVSSSVSE CYVQHGVLVA AWLVRGNFSD TAPRAYGTWG NERSATHFKV
GAPQLENDGA LRYETELPQV DARLSYVMLT VYPCSACNRS VLHCRPASRL PWLPLRVTPS
DLERLFAERR YLTFLYVVLV QFVKHVALFS FGVQVACCVY LRWIRPWVRG RHRATGRTSR
EEEAKDD
