ID   US108_SCHPO             Reviewed;         337 AA.
AC   Q09848;
DT   01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT   22-SEP-2009, sequence version 2.
DT   25-MAY-2022, entry version 108.
DE   RecName: Full=U1 snRNP-associated protein usp108;
GN   Name=usp108; ORFNames=SPAC23D3.08;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2]
RP   IDENTIFICATION IN THE U1 SNRNP COMPLEX, IDENTIFICATION BY MASS
RP   SPECTROMETRY, AND FUNCTION.
RX   PubMed=17264129; DOI=10.1093/nar/gkl1144;
RA   Newo A.N.S., Luetzelberger M., Bottner C.A., Wehland J., Wissing J.,
RA   Jaensch L., Kaeufer N.F.;
RT   "Proteomic analysis of the U1 snRNP of Schizosaccharomyces pombe reveals
RT   three essential organism-specific proteins.";
RL   Nucleic Acids Res. 35:1391-1401(2007).
CC   -!- FUNCTION: Component of the U1 snRNP particle, which recognizes and
CC       binds the 5'-splice site of pre-mRNA. Together with other non-snRNP
CC       factors, U1 snRNP forms the spliceosomal commitment complex, that
CC       targets pre-mRNA to the splicing pathway.
CC       {ECO:0000269|PubMed:17264129}.
CC   -!- SUBUNIT: Component of the U1 snRNP particle, a subcomplex of the
CC       spliceosome. {ECO:0000269|PubMed:17264129}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. Nucleus {ECO:0000305}.
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DR   EMBL; CU329670; CAA91243.2; -; Genomic_DNA.
DR   PIR; S62499; S62499.
DR   RefSeq; NP_594545.2; NM_001019974.3.
DR   AlphaFoldDB; Q09848; -.
DR   SMR; Q09848; -.
DR   BioGRID; 277989; 8.
DR   STRING; 4896.SPAC23D3.08.1; -.
DR   iPTMnet; Q09848; -.
DR   MaxQB; Q09848; -.
DR   PaxDb; Q09848; -.
DR   EnsemblFungi; SPAC23D3.08.1; SPAC23D3.08.1:pep; SPAC23D3.08.
DR   GeneID; 2541487; -.
DR   KEGG; spo:SPAC23D3.08; -.
DR   PomBase; SPAC23D3.08; usp108.
DR   VEuPathDB; FungiDB:SPAC23D3.08; -.
DR   eggNOG; KOG2190; Eukaryota.
DR   HOGENOM; CLU_824277_0_0_1; -.
DR   InParanoid; Q09848; -.
DR   OMA; VVPYIPD; -.
DR   PhylomeDB; Q09848; -.
DR   PRO; PR:Q09848; -.
DR   Proteomes; UP000002485; Chromosome I.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
DR   GO; GO:0005685; C:U1 snRNP; IDA:PomBase.
DR   GO; GO:0003723; F:RNA binding; ISM:PomBase.
DR   GO; GO:0000395; P:mRNA 5'-splice site recognition; IC:PomBase.
DR   Gene3D; 3.30.1370.10; -; 1.
DR   InterPro; IPR036612; KH_dom_type_1_sf.
DR   SUPFAM; SSF54791; SSF54791; 1.
DR   PROSITE; PS50084; KH_TYPE_1; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; mRNA processing; mRNA splicing; Nucleus; Reference proteome;
KW   Ribonucleoprotein; RNA-binding; Spliceosome.
FT   CHAIN           1..337
FT                   /note="U1 snRNP-associated protein usp108"
FT                   /id="PRO_0000050160"
FT   DOMAIN          263..327
FT                   /note="KH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00117"
SQ   SEQUENCE   337 AA;  36488 MW;  F4EEE4094396A915 CRC64;
     MDSGTSVVSI SADILRPPVL TAAQTFGDNE NECRVRLVLT AQQVQEWNLL PQDIQQEILK
     NGQVRVETYS SSNTARKIFI CTSSVSNLAS SIPALIKVVT PTKEEDASLN INLAVSSLIL
     GSKVLIHQNL IPSLFSVSNS TKLLYSASLL PRSSERLVTL ETNEIDASVV IETLLKYILS
     RISFIPRVSV VPYIPDAAYG IYGSPSTFTQ FNHMSSMVTP ENPYGIPPIA LTSAGGNPDP
     LRTTQVFPHS GPSIPLNIAA TQVVSQKMSV PSSLLDQLYH AMPHKLMEIS QNTNANITVE
     ESDSNSNEKF ISVVGTSEAN QSALMQLYAA LISLGRK