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US109_SCHPO
ID   US109_SCHPO             Reviewed;         365 AA.
AC   O94621;
DT   10-JAN-2003, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2012, sequence version 2.
DT   25-MAY-2022, entry version 117.
DE   RecName: Full=U1 snRNP-associated protein usp109;
GN   Name=usp109; ORFNames=SPBC1289.12;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2]
RP   REVISION OF GENE MODEL.
RX   PubMed=21511999; DOI=10.1126/science.1203357;
RA   Rhind N., Chen Z., Yassour M., Thompson D.A., Haas B.J., Habib N.,
RA   Wapinski I., Roy S., Lin M.F., Heiman D.I., Young S.K., Furuya K., Guo Y.,
RA   Pidoux A., Chen H.M., Robbertse B., Goldberg J.M., Aoki K., Bayne E.H.,
RA   Berlin A.M., Desjardins C.A., Dobbs E., Dukaj L., Fan L., FitzGerald M.G.,
RA   French C., Gujja S., Hansen K., Keifenheim D., Levin J.Z., Mosher R.A.,
RA   Mueller C.A., Pfiffner J., Priest M., Russ C., Smialowska A., Swoboda P.,
RA   Sykes S.M., Vaughn M., Vengrova S., Yoder R., Zeng Q., Allshire R.,
RA   Baulcombe D., Birren B.W., Brown W., Ekwall K., Kellis M., Leatherwood J.,
RA   Levin H., Margalit H., Martienssen R., Nieduszynski C.A., Spatafora J.W.,
RA   Friedman N., Dalgaard J.Z., Baumann P., Niki H., Regev A., Nusbaum C.;
RT   "Comparative functional genomics of the fission yeasts.";
RL   Science 332:930-936(2011).
RN   [3]
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   PubMed=16823372; DOI=10.1038/nbt1222;
RA   Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA   Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA   Yoshida M.;
RT   "ORFeome cloning and global analysis of protein localization in the fission
RT   yeast Schizosaccharomyces pombe.";
RL   Nat. Biotechnol. 24:841-847(2006).
RN   [4]
RP   IDENTIFICATION IN THE U1 SNRNP COMPLEX, IDENTIFICATION BY MASS
RP   SPECTROMETRY, AND DISRUPTION PHENOTYPE.
RX   PubMed=17264129; DOI=10.1093/nar/gkl1144;
RA   Newo A.N.S., Luetzelberger M., Bottner C.A., Wehland J., Wissing J.,
RA   Jaensch L., Kaeufer N.F.;
RT   "Proteomic analysis of the U1 snRNP of Schizosaccharomyces pombe reveals
RT   three essential organism-specific proteins.";
RL   Nucleic Acids Res. 35:1391-1401(2007).
CC   -!- SUBUNIT: Component of the U1 snRNP complex.
CC       {ECO:0000269|PubMed:17264129}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16823372}.
CC   -!- DISRUPTION PHENOTYPE: Leads to lethality.
CC       {ECO:0000269|PubMed:17264129}.
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DR   EMBL; CU329671; CAB38692.2; -; Genomic_DNA.
DR   PIR; T39363; T39363.
DR   RefSeq; NP_596836.2; NM_001023857.2.
DR   AlphaFoldDB; O94621; -.
DR   SMR; O94621; -.
DR   BioGRID; 276654; 14.
DR   STRING; 4896.SPBC1289.12.1; -.
DR   MaxQB; O94621; -.
DR   PaxDb; O94621; -.
DR   EnsemblFungi; SPBC1289.12.1; SPBC1289.12.1:pep; SPBC1289.12.
DR   GeneID; 2540117; -.
DR   KEGG; spo:SPBC1289.12; -.
DR   PomBase; SPBC1289.12; usp109.
DR   VEuPathDB; FungiDB:SPBC1289.12; -.
DR   eggNOG; KOG0118; Eukaryota.
DR   HOGENOM; CLU_016304_6_2_1; -.
DR   InParanoid; O94621; -.
DR   OMA; YWPALHA; -.
DR   PRO; PR:O94621; -.
DR   Proteomes; UP000002485; Chromosome II.
DR   GO; GO:0005829; C:cytosol; HDA:PomBase.
DR   GO; GO:0005634; C:nucleus; HDA:PomBase.
DR   GO; GO:0005685; C:U1 snRNP; IDA:PomBase.
DR   GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR   GO; GO:0000395; P:mRNA 5'-splice site recognition; IC:PomBase.
DR   GO; GO:0006376; P:mRNA splice site selection; IBA:GO_Central.
DR   Gene3D; 3.30.70.330; -; 3.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR000504; RRM_dom.
DR   Pfam; PF00076; RRM_1; 2.
DR   SMART; SM00360; RRM; 3.
DR   SUPFAM; SSF54928; SSF54928; 2.
DR   PROSITE; PS50102; RRM; 3.
PE   1: Evidence at protein level;
KW   Nucleus; Reference proteome; Repeat; RNA-binding.
FT   CHAIN           1..365
FT                   /note="U1 snRNP-associated protein usp109"
FT                   /id="PRO_0000082020"
FT   DOMAIN          3..79
FT                   /note="RRM 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   DOMAIN          86..162
FT                   /note="RRM 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   DOMAIN          189..259
FT                   /note="RRM 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
SQ   SEQUENCE   365 AA;  41553 MW;  E454A736EC3355BA CRC64;
     MSTSLWLNNL EEWMNEDYIR AIFENVRKVN YYEDGESGAI LKTCCIEFES QDAARNALER
     QSTQRLISGN PISLDVVPEW QKPSYYMLFI SNIDPEVSEN DIKYLFQRYN FISARVLRCV
     DGTSTSIAFI WLANESDIQN AQVEMQGAFC LKRSILVHSV KSDKNTYLSS PGFYGTPQPL
     NQFTDPNNTA VYVHQLPENI TTQELRSYFL HFGEILYTQV NNNSGRIVFA QRYFAEQAIN
     EMNNFPLHGV RIQLSWARPP SMALLPSKQS TYWPALAAPV YPSMKDVPNN PFTPFSPINP
     YYAKSWNHTA SAPLLPPGLK NGSDYPYLSV PPDILNDSYL AMCEAVNSRL DAESTMLLPV
     HYSQA
 
 
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