US10_HCMVA
ID US10_HCMVA Reviewed; 185 AA.
AC P09728; Q7M6J0;
DT 01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1989, sequence version 1.
DT 03-AUG-2022, entry version 90.
DE RecName: Full=Unique short US10 glycoprotein;
DE AltName: Full=Protein HXLF2;
DE AltName: Full=gpUS10;
DE Flags: Precursor;
GN Name=US10;
OS Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5).
OC Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC Herpesvirales; Herpesviridae; Betaherpesvirinae; Cytomegalovirus.
OX NCBI_TaxID=10360;
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=3031311; DOI=10.1016/0022-2836(86)90359-1;
RA Weston K.M., Barrell B.G.;
RT "Sequence of the short unique region, short repeats, and part of the long
RT repeats of human cytomegalovirus.";
RL J. Mol. Biol. 192:177-208(1986).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=2161319; DOI=10.1007/978-3-642-74980-3_6;
RA Chee M.S., Bankier A.T., Beck S., Bohni R., Brown C.M., Cerny R.,
RA Horsnell T., Hutchison C.A. III, Kouzarides T., Martignetti J.A.,
RA Preddie E., Satchwell S.C., Tomlinson P., Weston K.M., Barrell B.G.;
RT "Analysis of the protein-coding content of the sequence of human
RT cytomegalovirus strain AD169.";
RL Curr. Top. Microbiol. Immunol. 154:125-169(1990).
RN [3]
RP FUNCTION.
RX PubMed=12388737; DOI=10.1128/jvi.76.22.11753-11756.2002;
RA Furman M.H., Dey N., Tortorella D., Ploegh H.L.;
RT "The human cytomegalovirus US10 gene product delays trafficking of major
RT histocompatibility complex class I molecules.";
RL J. Virol. 76:11753-11756(2002).
RN [4]
RP GENOME REANNOTATION.
RX PubMed=12533697; DOI=10.1099/vir.0.18606-0;
RA Davison A.J., Dolan A., Akter P., Addison C., Dargan D.J., Alcendor D.J.,
RA McGeoch D.J., Hayward G.S.;
RT "The human cytomegalovirus genome revisited: comparison with the chimpanzee
RT cytomegalovirus genome.";
RL J. Gen. Virol. 84:17-28(2003).
RN [5]
RP ERRATUM OF PUBMED:12533697.
RA Davison A.J., Dolan A., Akter P., Addison C., Dargan D.J., Alcendor D.J.,
RA McGeoch D.J., Hayward G.S.;
RL J. Gen. Virol. 84:1053-1053(2003).
RN [6]
RP FUNCTION.
RX PubMed=20713594; DOI=10.1084/jem.20091793;
RA Park B., Spooner E., Houser B.L., Strominger J.L., Ploegh H.L.;
RT "The HCMV membrane glycoprotein US10 selectively targets HLA-G for
RT degradation.";
RL J. Exp. Med. 207:2033-2041(2010).
CC -!- FUNCTION: Plays a role in the modulation of host immune response by
CC reducing the presentation of HLA-G molecules at the cell surface.
CC Selectively targets HLA-G molecules for degradation by a mechanism
CC distinct from that used by US11. {ECO:0000269|PubMed:12388737,
CC ECO:0000269|PubMed:20713594}.
CC -!- SUBCELLULAR LOCATION: Host endoplasmic reticulum membrane
CC {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the HHV-5 US6 protein family. {ECO:0000305}.
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DR EMBL; X17403; CAA35277.1; -; Genomic_DNA.
DR EMBL; X04650; CAB37102.1; -; Genomic_DNA.
DR EMBL; BK000394; DAA00198.1; -; Genomic_DNA.
DR PIR; B27230; QQBEF2.
DR RefSeq; YP_081595.1; NC_006273.2.
DR DNASU; 3077551; -.
DR GeneID; 3077551; -.
DR KEGG; vg:3077551; -.
DR Proteomes; UP000008991; Genome.
DR Proteomes; UP000008992; Genome.
DR GO; GO:0044167; C:host cell endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR035128; US10.
DR Pfam; PF17617; US10; 1.
PE 3: Inferred from homology;
KW Disulfide bond; Glycoprotein; Host endoplasmic reticulum; Host membrane;
KW Host-virus interaction; Immunoglobulin domain; Membrane;
KW Reference proteome; Signal; Transmembrane; Transmembrane helix;
KW Viral immunoevasion.
FT SIGNAL 1..24
FT /evidence="ECO:0000255"
FT CHAIN 25..185
FT /note="Unique short US10 glycoprotein"
FT /id="PRO_0000037443"
FT TOPO_DOM 25..149
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 150..170
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 171..185
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 30..133
FT /note="Ig-like H-type"
FT CARBOHYD 111
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT CARBOHYD 143
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT DISULFID 39..129
FT /evidence="ECO:0000250"
SQ SEQUENCE 185 AA; 20771 MW; 43B67DA189A5EF93 CRC64;
MLRRGSLRNP LAICLLWWLG VVAAATEETR EPTYFTCGCV IQNHVLKGAV KLYGQFPSPK
TLRASAWLHD GENHERHRQP ILVEGTATAT EALYILLPTE LSSPEGNRPR NYSATLTLAS
RDCYERFVCP VYDSGTPMGV LMNLTYLWYL GDYGAILKIY FGLFCGACVI TRSLLLICGY
YPPRE
