ID   US10_HCMVM              Reviewed;         185 AA.
AC   F5HFJ7;
DT   11-JUL-2012, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   03-AUG-2022, entry version 32.
DE   RecName: Full=Membrane glycoprotein US10;
DE   Flags: Precursor;
GN   Name=US10;
OS   Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Cytomegalovirus.
OX   NCBI_TaxID=295027;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15105547; DOI=10.1099/vir.0.79888-0;
RA   Dolan A., Cunningham C., Hector R.D., Hassan-Walker A.F., Lee L.,
RA   Addison C., Dargan D.J., McGeoch D.J., Gatherer D., Emery V.C.,
RA   Griffiths P.D., Sinzger C., McSharry B.P., Wilkinson G.W.G., Davison A.J.;
RT   "Genetic content of wild-type human cytomegalovirus.";
RL   J. Gen. Virol. 85:1301-1312(2004).
CC   -!- FUNCTION: Plays a role in the modulation of host immune response by
CC       down-regulating the surface presentation of HLA-G molecules.
CC       Selectively targets HLA-G molecules for degradation by a mechanism
CC       distinct from the one used by US11.
CC   -!- SUBCELLULAR LOCATION: Host endoplasmic reticulum membrane
CC       {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the HHV-5 US6 protein family. {ECO:0000305}.
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DR   EMBL; AY446894; AAR31699.1; -; Genomic_DNA.
DR   RefSeq; YP_081595.1; NC_006273.2.
DR   PRIDE; F5HFJ7; -.
DR   DNASU; 3077551; -.
DR   GeneID; 3077551; -.
DR   KEGG; vg:3077551; -.
DR   Reactome; R-HSA-9609690; HCMV Early Events.
DR   Proteomes; UP000000938; Genome.
DR   GO; GO:0044167; C:host cell endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR035128; US10.
DR   Pfam; PF17617; US10; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; Glycoprotein; Host endoplasmic reticulum; Host membrane;
KW   Host-virus interaction; Immunoglobulin domain; Membrane;
KW   Reference proteome; Signal; Transmembrane; Transmembrane helix;
KW   Viral immunoevasion.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   CHAIN           25..185
FT                   /note="Membrane glycoprotein US10"
FT                   /id="PRO_0000418251"
FT   TOPO_DOM        25..149
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        150..170
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        171..185
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          30..133
FT                   /note="Ig-like H-type"
FT   CARBOHYD        111
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        143
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   DISULFID        39..129
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   185 AA;  20771 MW;  43B67DA189A5EF93 CRC64;
     MLRRGSLRNP LAICLLWWLG VVAAATEETR EPTYFTCGCV IQNHVLKGAV KLYGQFPSPK
     TLRASAWLHD GENHERHRQP ILVEGTATAT EALYILLPTE LSSPEGNRPR NYSATLTLAS
     RDCYERFVCP VYDSGTPMGV LMNLTYLWYL GDYGAILKIY FGLFCGACVI TRSLLLICGY
     YPPRE