ID   US10_HHV11              Reviewed;         312 AA.
AC   P06486;
DT   01-JAN-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1988, sequence version 1.
DT   02-JUN-2021, entry version 81.
DE   RecName: Full=Virion protein US10;
GN   Name=US10;
OS   Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Alphaherpesvirinae; Simplexvirus.
OX   NCBI_TaxID=10299;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=2984429; DOI=10.1016/0022-2836(85)90320-1;
RA   McGeoch D.J., Dolan A., Donald S., Rixon F.J.;
RT   "Sequence determination and genetic content of the short unique region in
RT   the genome of herpes simplex virus type 1.";
RL   J. Mol. Biol. 181:1-13(1985).
RN   [2]
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=6324121; DOI=10.1093/nar/12.5.2473;
RA   Rixon F.J., McGeoch D.J.;
RT   "A 3' co-terminal family of mRNAs from the herpes simplex virus type 1
RT   short region: two overlapping reading frames encode unrelated polypeptide
RT   one of which has highly reiterated amino acid sequence.";
RL   Nucleic Acids Res. 12:2473-2487(1984).
RN   [3]
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=2839594; DOI=10.1099/0022-1317-69-7-1531;
RA   McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C., McNab D.,
RA   Perry L.J., Scott J.E., Taylor P.;
RT   "The complete DNA sequence of the long unique region in the genome of
RT   herpes simplex virus type 1.";
RL   J. Gen. Virol. 69:1531-1574(1988).
RN   [4]
RP   PHOSPHORYLATION, AND SUBCELLULAR LOCATION.
RC   STRAIN=KOS;
RX   PubMed=9367380; DOI=10.1099/0022-1317-78-11-2923;
RA   Yamada H., Daikoku T., Yamashita Y., Jiang Y.M., Tsurumi T., Nishiyama Y.;
RT   "The product of the US10 gene of herpes simplex virus type 1 is a
RT   capsid/tegument-associated phosphoprotein which copurifies with the nuclear
RT   matrix.";
RL   J. Gen. Virol. 78:2923-2931(1997).
CC   -!- SUBCELLULAR LOCATION: Virion tegument {ECO:0000250}. Host nucleus
CC       matrix {ECO:0000269|PubMed:9367380}.
CC   -!- INDUCTION: Expressed late in the infection cycle.
CC   -!- PTM: Phosphorylated. {ECO:0000269|PubMed:9367380}.
CC   -!- SIMILARITY: Belongs to the herpesviridae US10 family. {ECO:0000305}.
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DR   EMBL; X02138; CAA26064.2; -; Genomic_DNA.
DR   EMBL; X00428; CAA25126.1; -; Genomic_RNA.
DR   EMBL; L00036; AAA96678.1; -; Genomic_DNA.
DR   EMBL; X14112; CAA32275.1; -; Genomic_DNA.
DR   PIR; A05242; QQBE07.
DR   RefSeq; YP_009137146.1; NC_001806.2.
DR   PRIDE; P06486; -.
DR   DNASU; 2703436; -.
DR   GeneID; 2703436; -.
DR   KEGG; vg:2703436; -.
DR   Proteomes; UP000009294; Genome.
DR   GO; GO:0044204; C:host cell nuclear matrix; IEA:UniProtKB-SubCell.
DR   GO; GO:0019033; C:viral tegument; IEA:UniProtKB-SubCell.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   InterPro; IPR000714; EHV_Unk.
DR   Pfam; PF02053; Gene66; 1.
DR   PRINTS; PR00957; GENE66.
PE   1: Evidence at protein level;
KW   Host nucleus; Metal-binding; Phosphoprotein; Reference proteome; Virion;
KW   Virion tegument; Zinc; Zinc-finger.
FT   CHAIN           1..312
FT                   /note="Virion protein US10"
FT                   /id="PRO_0000116145"
FT   ZN_FING         271..283
FT                   /evidence="ECO:0000255"
FT   REGION          20..106
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          143..170
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        82..99
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   312 AA;  34056 MW;  12D01B0E7C920EA3 CRC64;
     MIKRRGNVEI RVYYESVRTL RSRSHLKPSD RQQSPGHRVF PGSPGFRDHP ENLGNPEYRE
     LPETPGYRVT PGIHDNPGLP GSPGLPGSPG LPGSPGPHAP PANHVRLAGL YSPGKYAPLA
     SPDPFSPQHG AYARARVGIH TAVRVPPTGS PTHTHLRQDP GDEPTSDDSG LYPLDARALA
     HLVMLPADHR AFFRTVVEVS RMCAANVRDP PPPATGAMLG RHARLVHTQW LRANQETSPL
     WPWRTAAINF ITTMAPRVQT HRHMHDLLMA CAFWCCLTHA STCSYAGLYS THCLHLFGAF
     GCGDPALTPP LC