ID   US11_HCMVT              Reviewed;         215 AA.
AC   Q8UZK5;
DT   01-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   03-AUG-2022, entry version 59.
DE   RecName: Full=Unique short US11 glycoprotein;
DE   AltName: Full=HXLF1;
DE   AltName: Full=gpUS11;
DE   Flags: Precursor;
GN   Name=US11;
OS   Human cytomegalovirus (strain Towne) (HHV-5) (Human herpesvirus 5).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Cytomegalovirus.
OX   NCBI_TaxID=10363;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Crew M.D.;
RT   "Immune evasion genes from the Towne strain of human cytomegalovirus.";
RL   Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Participates in the inhibition of the host immune response.
CC       Redirects newly synthesized major histocompatibility complex (MHC)
CC       class I heavy chains via the SEC61 translocon to the cytosol where they
CC       undergo proteasome-dependent destruction. In consequence, infected
CC       cells are masked for immune recognition by cytotoxic T-lymphocytes.
CC       {ECO:0000250|UniProtKB:P09727}.
CC   -!- SUBUNIT: Interacts with host TRAM1. {ECO:0000250|UniProtKB:P09727}.
CC   -!- SUBCELLULAR LOCATION: Host endoplasmic reticulum membrane
CC       {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
CC   -!- DEVELOPMENTAL STAGE: Expressed at early and late period of virus
CC       infection.
CC   -!- SIMILARITY: Belongs to the cytomegalovirus US6 family. {ECO:0000305}.
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DR   EMBL; AY072776; AAL67144.1; -; Genomic_DNA.
DR   TCDB; 3.A.16.1.1; the endoplasmic reticular retrotranslocon (er-rt) family.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0044386; C:integral to host endoplasmic reticulum membrane; IEA:InterPro.
DR   InterPro; IPR012536; CMV_US.
DR   Pfam; PF08001; CMV_US; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Early protein; Glycoprotein; Host endoplasmic reticulum;
KW   Host membrane; Host-virus interaction; Immunoglobulin domain; Late protein;
KW   Membrane; Signal; Transmembrane; Transmembrane helix; Viral immunoevasion.
FT   SIGNAL          1..17
FT                   /evidence="ECO:0000250"
FT   CHAIN           18..215
FT                   /note="Unique short US11 glycoprotein"
FT                   /id="PRO_0000037445"
FT   TOPO_DOM        18..182
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        183..203
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        204..215
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          47..146
FT                   /note="Ig-like H-type"
FT   CARBOHYD        73
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   DISULFID        56..142
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   215 AA;  25302 MW;  34C7A05BD39A81D9 CRC64;
     MNLIMLILAL WAPVAGSMPE LSLTLFDEPP PLVETEPLPP LPDVSEYRVE YSEARCVLRS
     GGRLEALWTL RGNLSVPTPT PRVYYQTLEG YADRVPTPVE DISESLVAKR YWLRDYRVPQ
     RTKLVLFYFS PCHQCQTYYV ECEPRCLVPW VPLWSSLEDI ERLLFEDRRL MAYYALTIKS
     AQYTLMMVAV IQVFWGLYVK GWLHRHFPWM FSDQW