ID   US12_HCMVA              Reviewed;         281 AA.
AC   P09721; Q7M6I8;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1989, sequence version 1.
DT   23-FEB-2022, entry version 67.
DE   RecName: Full=Uncharacterized protein HVLF6;
GN   Name=US12;
OS   Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Cytomegalovirus.
OX   NCBI_TaxID=10360;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=3031311; DOI=10.1016/0022-2836(86)90359-1;
RA   Weston K.M., Barrell B.G.;
RT   "Sequence of the short unique region, short repeats, and part of the long
RT   repeats of human cytomegalovirus.";
RL   J. Mol. Biol. 192:177-208(1986).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=2161319; DOI=10.1007/978-3-642-74980-3_6;
RA   Chee M.S., Bankier A.T., Beck S., Bohni R., Brown C.M., Cerny R.,
RA   Horsnell T., Hutchison C.A. III, Kouzarides T., Martignetti J.A.,
RA   Preddie E., Satchwell S.C., Tomlinson P., Weston K.M., Barrell B.G.;
RT   "Analysis of the protein-coding content of the sequence of human
RT   cytomegalovirus strain AD169.";
RL   Curr. Top. Microbiol. Immunol. 154:125-169(1990).
RN   [3]
RP   GENOME REANNOTATION.
RX   PubMed=12533697; DOI=10.1099/vir.0.18606-0;
RA   Davison A.J., Dolan A., Akter P., Addison C., Dargan D.J., Alcendor D.J.,
RA   McGeoch D.J., Hayward G.S.;
RT   "The human cytomegalovirus genome revisited: comparison with the chimpanzee
RT   cytomegalovirus genome.";
RL   J. Gen. Virol. 84:17-28(2003).
RN   [4]
RP   ERRATUM OF PUBMED:12533697.
RA   Davison A.J., Dolan A., Akter P., Addison C., Dargan D.J., Alcendor D.J.,
RA   McGeoch D.J., Hayward G.S.;
RL   J. Gen. Virol. 84:1053-1053(2003).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the cytomegalovirus US12 family. {ECO:0000305}.
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DR   EMBL; X17403; CAA35279.1; -; Genomic_DNA.
DR   EMBL; X04650; CAB37104.1; -; Genomic_DNA.
DR   EMBL; BK000394; DAA00200.1; -; Genomic_DNA.
DR   PIR; D27230; QQBEF4.
DR   Proteomes; UP000008991; Genome.
DR   Proteomes; UP000008992; Genome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR006214; Bax_inhibitor_1-related.
DR   Pfam; PF01027; Bax1-I; 1.
PE   3: Inferred from homology;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..281
FT                   /note="Uncharacterized protein HVLF6"
FT                   /id="PRO_0000115271"
FT   TRANSMEM        58..78
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        88..107
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        117..137
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        145..165
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        171..191
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        196..216
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        248..268
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          11..30
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   281 AA;  32469 MW;  56DF9D497B74DF5D CRC64;
     MVQIQFHQGE PLGHKKEKPP PVSPPSPPPI RRVTVITKDE DTLRSVQHFL WMVRLYGTVV
     FQTSATIATT ILFMLIPWRV TAPYLRDTLP FWSTLLPCAL RCHAYWLERR RRPGTLMLVM
     VYTTLTTISV STIGLCFDRT VVIQAYVLSS MLCVWCTGLA WLMAWNMQRR LAILCLLSFM
     LPILWLFIAV QSWEPYQRII LALTVSFIYG LKIVLIRDTL TVLYRSPSNC YTDGDLLRTA
     MLLYMDQVIM FLLVVVPLTA PIWYPNYAGA LGRTAHWLFH K